This Week in Virology

TWiV 470: Just a passing phage

December 3, 2017

The TWiV ninjas reveal that bacteriophage particles rapidly move across monolayers of eukaryotic cells from different tissues.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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Transcytosis of bacteriophage across cell layers (mBio)
Image credit
Letters read on TWiV 470

This episode is brought to you by Blue Apron. Blue Apron is the #1 fresh ingredient and recipe delivery service in the country. Get $30 off your first delivery and FREE SHIPPING by going to blueapron.com/twiv.

Weekly Science Picks

Kathy – Photo of 3200 year-old tree in one image
Dickson – Microsculpture
Rich – A Short History Of Humans And Germs
Alan – Planets app
Vincent – Laptops Are Great. But Not During a Lecture or a Meeting

Listener Picks

Basel – Joint Pathology Center
John – OpenStax

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 469: Mycovirus stuffed potatoes

November 26, 2017

The TWiV hosts discuss a plant virus that infects a fungus, and whether you need to work insane hours to succeed in science.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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Download TWiV 469 (66 MB .mp3, 108 min)
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This episode is brought to you by the Department of Microbiology at the Icahn School of Medicine at Mount Sinai. Composed of over 20 virology labs, all centralized in one building in the heart of New York City, this department is a perfect fit for anyone with an interest in pursuing virus research. For more information about the Department, visit http://bit.ly/micromssm

This episode is brought to you by the Virology and Gene Therapy PhD program at the Mayo Clinic Graduate School of Biomedical Sciences in Rochester, Minnesota. The renowned Mayo Clinic Virology and Gene Therapy program is currently accepting applications until December first. If you want to be trained in the exciting fields of oncolytic virotherapy, gene therapy, vaccine creation, or basic virology, visit mayoclinic.org to apply to the Virology and Gene Therapy program at the Mayo Clinic Graduate School of Biomedical Sciences.

Weekly Science Picks 1:27:07

Kathy – Patterns Video (WonderLab)
Dickson – Nikon 2017 Photomicrography Contest
Rich – Leonardo Da Vinci by Walter Isaacson
Alan – Sail Magazine Best Boats 2018
Vincent – Science Is Dry, Obscure, Complex?

Listener Picks

Ben – Is the staggeringly profitable business of scientific publishing bad for science?

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 468: Zika by the slice

November 19, 2017

Amy joins the TWiV team to talk about her career and her work on Zika virus neurotropism using embryonic mouse organotypic brain slice cultures.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Amy Rosenfeld

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Download TWiV 468 (66 MB .mp3, 107 min)
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Links for this episode

Grad students face tax hike (Nature)
House voted to bankrupt grad students (NYTimes)
Neurotropism of early and late Zika virus isolates (PNAS)
Zika virus blocks the neuron road (virology blog)
Letters read on TWiV 468

Weekly Science Picks

Amy – Forgotten Mothers and Babies of Zika (Facebook page)
Kathy – A tapestry of time and terrain
Dickson – SciTech #406
Rich – Letters to a Young Scientist by EO Wilson; TED talk; “Chasing a Killer”
Alan – Soil ecology clay animations
Vincent – Oxygen by Nick Lane

Listener Picks

Islam – Downcastapp.com
Steve – Female Virologists

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 467: Jon and Ted’s Excellent Adventure

November 12, 2017

Jon and Teddy Yewdell join the TWiV team to talk about their careers, their research, and the problems with biomedical research.

Hosts: Vincent Racaniello, Alan Dove,and Rich Condit

Guest: Jon Yewdell and Teddy Yewdell

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Links for this episode

Jon Yewdell laboratory
Chaudhuri laboratory
Truth Wins by Jon Yewdell (epub or mobi download)
Noncoding RNAs and class switch recombination (Int Imm)
Translating DRiPs (J Leuk Biol)
Lamprey VLRP response to influenza virus (eLife)
The Biomedical Research Crisis (TWiV 208)

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 466: The Capsid Club

November 5, 2017

From Indiana University, Vincent and Kathy speak with Tuli Mukhopadhyay, John Patton, and Adam Zlotnick about their careers and their work on alphaviruses, hepatitis B virus, and rotaviruses.

Host: Vincent Racaniello and Kathy Spindler

Guests: Tuli Mukhopadhyay, John Patton, and Adam Zlotnick

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Links for this episode

Mukhopadhyay lab
Patton lab
Zlotnick lab
Tuli on Twitter
Palmitoylation of Sindbis virus TF protein (J Virol)
Hepatitis B virus structure (Ann Rev Virol)
Rotavirus RNA polymerase (Curr Opin Virol)

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 465: Theodora the explorer

October 29, 2017

Theodora Hatziioannou joins the TWiV team to discuss a macaque model for AIDS, and how a cell protein that blocks HIV-1 infection interacts with double-stranded RNA.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Theodora Hatziioannou

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Download TWiV 465 (53 MB .mp3, 88 min)
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Links for this episode

ASU-UofA Joint Virology Symposium
Laboratory of Retrovirology, Rockefeller University
HIV-1-induced AIDS in monkeys (Science)
APOBEC3H bound to duplex RNA (Nat Comm)
Center for HIV RNA studies
Image: Two molecules of APOBEC3H bound to dsRNA

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at http://www.cbdstconference.com

Weekly Science Picks

Theodora – To Kill A Mockingbird by Harper Lee
Kathy – 25 MILLION Orbeez in a pool
Dickson – Fluid Dynamics of Paint
Rich – The Hitchhiker’s Guide to the Galaxy by Douglas Adams
Alan – 30 days at sea: timelapse
Vincent – TWiEVO 24 and Every Time Zone

Listener Picks

Fernando – Lego Women of NASA

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 464: Boston baked viruses

October 22, 2017

At Tufts University Dental School in Boston, Vincent speaks with Katya Heldwein and Sean Whelan about their careers and their work on herpesvirus structure and replication of vesicular stomatitis virus.

Host: Vincent Racaniello

Guests: Katya Heldwein and Sean Whelan

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Links for this episode

Crystal structure of HSV gB (Science)
Crystal structure of HSV fusion regulator gH-gL (Nat Struct Mol Biol)
Nuclear Exodus: Herpesviruses Lead the Way (Ann Rev Virol)
VSV Pseudotypes Bearing gB, gD, gH, and gL (J Virol)
Recovery of infectious VSV from cDNA clones (PNAS)
Structure of the L Protein of VSV (Cell)
Unique strategy for mRNA cap methylation by VSV (PNAS)
Molecular architecture of VSV RNA polymerase (PNAS)

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 463: We haven’t meth but these names ring Nobel

October 15, 2017

The TWiViridae review the 2017 Nobel Prizes for cryoEM and circadian rhythms, and discuss modulation of plant virus replication by RNA methylation.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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Download TWiV 463 (63 MB .mp3, 104 min)
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Links for this episode

Truth Wins by Jonathan Yewdell (epub or mobi)
Gabriel Victora awarded MacArthur Prize
Forty Years of mRNA Splicing (CSH)
2017 Chemistry Nobel: Jacques Dubochet, Joachim Frank, Richard Henderson
2017 Physiology or Medicine Nobel: Jeffrey C. Hall, Michael Rosbash, Michael W. Young
2017 Nobel Prize in Chemistry (pdf)
2017 Nobel Prize in Physiology of Medicine (pdf)
Jonathan Weiner on TWiEVO 19
RNA methylation modulates plant virus infectivity (PNAS)
Christine Racaniello’s marked up copy of Arrowsmith (jpg)
Letters read on TWiV 463

Weekly Science Picks

Kathy – When biospheres collide
Dickson – Blame 10 rivers for ocean plastic
Alan – Farming in The Netherlands
Vincent – Meet the Microbiologist

Listener Picks

Jay – OmegaTau podcast
Trudy – Arrowsmith by Sinclair Lewis
Mark – iOS app Human Anatomy Atlas and Master in Business podcast

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV Special: Tear it up with David Tuller

October 14, 2017

David Tuller returns to discuss his efforts to expose the methodological and ethical problems with the PACE trial for ME/CFS.

Hosts: Vincent Racaniello

Guest: David Tuller

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Links for this episode

All of David’s ME/CFS articles at virology blog
David Tuller on Twitter
Through the Shadowlands by Julie Rehmeyer

Intro music is by Ronald Jenkees.

Send your virology questions and comments to twiv@microbe.tv

TWiV 462: Splicing RNA with Phillip A. Sharp

October 8, 2017

Vincent speaks with 1993 Nobel Laureate Phillip A. Sharp about his career and his seminal discovery of RNA splicing in mammalian cells, which changed our understanding of gene structure.