This Week in Virology

TWiV 608: Daniel Griffin’s COVID-19 clinical report

May 1, 2020

Daniel Griffin updates the clinical situation with COVID-19 patients, followed by analysis of the remedesivir clinical trial results, and answers listener questions.

Hosts: Vincent Racaniello and Rich Condit

Guest: Daniel Griffin

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Download TWiV 608 (35 MB .mp3, 57 min)
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Intro music is by Ronald Jenkees.

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TWiV 607: Coronavirus epidemiology with Jeff Shaman

April 29, 2020

Jeff Shaman returns to TWiV to explain why more SARS-CoV-2 testing and contact tracing is needed to stop the pandemic, and provide insights on immunity and reinfection from seasonal CoVs, the problems with antibody tests, and what to expect in the coming months.

Hosts: Vincent Racaniello and Rich Condit

Guest: Jeff Shaman

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Download TWiV 607 (41 MB .mp3, 68 min)
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Intro music is by Ronald Jenkees.

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TWiV 606: Evidence-based science and medicine for COVID-19

April 26, 2020

Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by our discussion of tests of an inactivated vaccine, results of serological surveys, an inhibitor of the cell protease needed for virus entry, and answers to listener questions.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Daniel Griffin

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Download TWiV 606 (69 MB .mp3, 114 min)
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Inactivated SARS-CoV-2 vaccine protects monkeys (bioRxiv) 45:06
Saliva is more sensitve than nasopharyngeal swab (medRxiv)48:48
NY serological survey results (NY Times) 57:36
FDA caveats on serological tests (FDA) 57:53
Federal guidelines on when to open 1:07:15
When to open: Roadmap, blog, video explainer 1:07:22
Blocking TMPRSS2 blocks SARS-CoV-2 infection (Cell) 1:11:18
Lawmakers want human challenge studies (Science) 1:15:28
Letters read on TWiV 606
Image credit
Timestamps by Jolene. Thanks!
Kiki’s Comments – Summary of this episode

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 605: READDI for the next pandemic

April 23, 2020

Ralph Baric, Mark Heise and Nat Moorman discuss their non-profit initiative READDI, Rapidly Emerging Antiviral Drug Discovery Initiative, to start making drugs now for the next pandemic virus.

Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler

Guests: Ralph Baric, Mark Heise, and Nat Moorman

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Download TWiV 605 (32 MB .mp3, 53 min)
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READDI.org 6:55
CEPI 20:43
DNDi 24:31
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 604: Oral poliovaccine to prevent SARS-CoV-2 infection

April 21, 2020

Kostya Chumakov discusses the hypothesis that oral poliovirus vaccine can provide non-specific protection against many other viruses, and might prevent infection with SARS-CoV-2.

Host: Vincent Racaniello

Guest: Kostya Chumakov

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Download TWiV 604 (39 MB .mp3, 64 min)
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Nonpathogenic enteroviruses to prevent human disease (pdf) 6:13
OPV for COVID-19 (pdf) 17:56
Enteroviruses to prevent human infections (pdf) 7:08
Image credit
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 603: Cloudy with a chance of coronavirus

April 19, 2020

Daniel Griffin provides his weekly update on the COVID-19 clinical situation, followed by results of seroprevalence studies, analysis of CpG dinucleotide frequencies in the SARS-CoV-2 genome, and answers to listener questions.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Daniel Griffin

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Download TWiV 603 (70 MB .mp3, 116 min)
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Intro music is by Ronald Jenkees.

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TWiV 602: Coronavirus immunology with Stanley Perlman

April 16, 2020

Stanley Perlman joins TWiV to discuss immune responses to coronaviruses, including seasonal CoV, MERS, SARS, and SARS-CoV-2, including prospects for a vaccine.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Stanley Perlman

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Download TWiV 602 (45 MB .mp3, 74 min)
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Perlman Laboratory 1:39
An Iowa Caucus of Viruses (TWiV 538) 2:00
Anti-SARS-CoV spike IgG and acute lung injury (JCI Insight) 28:07
T cell responses to respiratory CoV (Immunol Res) 19:13
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 601: Das coronavirus with Christian Drosten

April 14, 2020

Coronavirus expert Christian Drosten joins Vincent to provide a view from Germany on COVID-19 and SARS-CoV-2.

Host: Vincent Racaniello

Guest: Christian Drosten

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Download TWiV 601 (34 MB .mp3, 56 min)
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Das Coronavirus podcast 1:00
Identification of SARS-CoV in Germany (NEJM) 3:13
29 nt deletion in genome of SARS-CoV (Sci Rep) 34:20
382 nt deletion in genome of SARS-CoV-2 (bioRxiv) 38:00
Virological assessment of COVID-19 patients (Nature) 26:29
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 600: SARS-CoV-2 – enter the Coronials

April 12, 2020

Daniel Griffin joins TWiV to update on the clinical situation, then we discuss a 382 nucleotide deletion in the SARS-CoV-2 genome, a scenario for emergence of the virus from a bat, followed by answers to listener email.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Daniel Griffin

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Download TWiV 600 (69 MB .mp3, 113 min)
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Links for this episode

382 nt deletion in genome of SARS-CoV-2 (bioRxiv) 45:23
Recombination and mutation leading to SARS-CoV-2 (bioRxiv) 49:09
Letters read on TWiV 600 20:39, 31:47, 41:34, 42:48, 54:15
Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees.

Send your virology questions and comments to [email protected]

TWiV 599: Coronavirus update – we need a plan

April 8, 2020

Doris Cully joins TWiV to discuss inhibition of SARS-CoV-2 in cell culture by ivermectin, followed by continuing analysis of the coronavirus pandemic caused by SARS-CoV-2 including COVID-19 in Nadia the tiger, and prediction of respiratory failure by levels of IL-6.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

Guest: Doris Cully

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Download TWiV 599 (77 MB .mp3, 128 min)
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