Maria joins TWiN to explain how single-cell transcriptomics is being used to reveal the evolution of the brain, at a cost of about $1 per neuron.
TWiN explains how a cytokine produced by neurons activates microglia which modify the extracellular matrix and remodel synapses, leading to memory consolidation.
Columbia University Chief Neurology Resident Genna Waldman joins TWiN to explains how her department prepared for COVID-19, and the neurological symptoms associated with the disease.
TWiN 8: Replacing lost neurons
- July 7, 2020
- Tagged as: astrocytes, CRISPR, dopamine, gene editing, glial cells, neurology, neurons, neuroscience, neurotransmitter
TWiN explains how neurological disease in mice can be repaired by using CRISPR/Cas to knock down levels of a single cell protein, which converts astrocytes to neurons.
TWiN 7: Stress, the good, bad and beautiful
- June 13, 2020
- Tagged as: antibodies, B cells, brain, germinal center, gray hair, immune responses, nerves, nervous system, neuroscience, spinal cord, spleen, stress, T cells
The TWiN team reveals how the nervous system controls hair graying in mice subjected to stress, and adaptive immune responses.
TWiN 6: Neural control of sexual behavior
- May 20, 2020
- Tagged as: brain, gender, neurobiology, neuroscience, sexual behavior
Nirao Shah joins TWiN to discuss the work of his laboratory on how our brains generate social interactions that differ between the sexes.
Bob Datta joins TWiN to reveal the findings of his laboratory on expression of SARS-CoV-2 entry genes in the olfactory epithelium and the implications for anosmia associated with COVID-19.
TWiN 4: It’s a trap!
- January 9, 2020
- Tagged as: ACBAR, exoxomes, gag protein, information transfer, memory, neurology, neuroscience, retrotransposon, synapse
Jason visits the TWiN studio to explain Arc Capsid Bearing Any RNAs (ACBARs), virus-like capsids that transfer genetic information between neurons.
Erin and the TWiN team explain how dopamine neurons encode reward probability and uncertainty, and their roles in attention-based learning and risk-taking such as gambling and addiction.
The TWiN team explain the basic principles of synaptic transmission, and review a classic paper demonstrating that recycling endosomes are important for modifying synaptic strength, which is involved in information storage and processing.
About the Hosts
Jason Shepherd, Ph.D.
Vivianne Morrison, Ph.D.
Tim Cheung, Ph.D.
Vincent Racaniello, Ph.D.