Stefano joins TWiN to discuss his work on understanding genomic decoding of neuronal depolarization by stimulus-specific transcriptional regulators.
Helen joins TWiN to discuss her work on understanding how the maternal microbiome modulates fetal neurodevelopment in mice.
TWiN 14: Reducing Alzheimer-like pathology in mice
- January 14, 2021
- Tagged as: Alzheimer disease, amyloid beta, amyloid plaque, neurology, neuron, neuroscience
Ori, Jason, and Vincent discuss the use of antibodies to neutralize amyloid-β seeds before their deposition becomes detectable in transgenic mice, and the finding that the preclinical phase of Alzheimer‘s disease may be a late manifestation of earlier pathogenic seed formation.
Ori, Jason, Erin, and Vincent dissect a study that utilizes single-cell RNA sequencing to reveal the genes that underlie remote memory storage in the medial prefrontal cortex of the mouse.
Ori, Jason, and Vincent reveal identification of an orphan receptor that modifies short-term memory in mice, and a mouse model of COVID-19 that includes anosmia or loss of smell.
Maria joins TWiN to explain how single-cell transcriptomics is being used to reveal the evolution of the brain, at a cost of about $1 per neuron.
TWiN explains how a cytokine produced by neurons activates microglia which modify the extracellular matrix and remodel synapses, leading to memory consolidation.
Columbia University Chief Neurology Resident Genna Waldman joins TWiN to explains how her department prepared for COVID-19, and the neurological symptoms associated with the disease.
TWiN 8: Replacing lost neurons
- July 7, 2020
- Tagged as: astrocytes, CRISPR, dopamine, gene editing, glial cells, neurology, neurons, neuroscience, neurotransmitter
TWiN explains how neurological disease in mice can be repaired by using CRISPR/Cas to knock down levels of a single cell protein, which converts astrocytes to neurons.
TWiN 7: Stress, the good, bad and beautiful
- June 13, 2020
- Tagged as: antibodies, B cells, brain, germinal center, gray hair, immune responses, nerves, nervous system, neuroscience, spinal cord, spleen, stress, T cells
The TWiN team reveals how the nervous system controls hair graying in mice subjected to stress, and adaptive immune responses.
About the Hosts
Jason Shepherd, Ph.D.
Vivianne Morrison, Ph.D.
Vincent Racaniello, Ph.D.