TWiN 8: Replacing lost neurons

July 7, 2020

TWiN explains how neurological disease in mice can be repaired by using CRISPR/Cas to knock down levels of a single cell protein, which converts astrocytes to neurons.

Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd and Vincent Racaniello

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Intro music is by Ronald Jenkees

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2 comments on “TWiN 8: Replacing lost neurons

  1. Re:Converting glia to neurons (Cell)

    So do these converted glia precursor cells have centrioles? I assume they did. Do they post-conversion? I’ve seen data on neurogenesis in the hippocampus but it is short-lived.

    This is cool… I need to find a version I can read completely… I don’t have access to Cell … but this is nicely done it looks like.

    I can’t see the data very well… is there matching dendritic branching for these nerves? How are the surronding nervers reacting to this conversion?

  2. Bruce Fehr Jul 7, 2020

    Intriguing science..thanks for sharing.
    Bruce Fehr