TWiN explains how neurological disease in mice can be repaired by using CRISPR/Cas to knock down levels of a single cell protein, which converts astrocytes to neurons.
Hosts: Ori Lieberman, Erin Calipari, Jason Shepherd and Vincent Racaniello
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Download TWiN 008 (43 MB .mp3, 71 min)
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Links for this episode
- Converting glia to neurons (Cell) 13:51
- Reversing Parkinson’s disease (Nature) 39:50
- Letters read on TWiN 8 1:07:50
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees
Send your neuroscience questions and comments to twin@microbe.tv
Re:Converting glia to neurons (Cell)
So do these converted glia precursor cells have centrioles? I assume they did. Do they post-conversion? I’ve seen data on neurogenesis in the hippocampus but it is short-lived.
This is cool… I need to find a version I can read completely… I don’t have access to Cell … but this is nicely done it looks like.
I can’t see the data very well… is there matching dendritic branching for these nerves? How are the surronding nervers reacting to this conversion?
Intriguing science..thanks for sharing.
Bruce Fehr