Vincent travels to the Karolinska Institute in Stockholm on 31 May 2024 to meet with Dr. Judith Bruchfeld and discuss her research on the etiology and treatment of Long COVID.

Hosts: Vincent Racaniello

Guest: Judith Bruchfeld

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Immune system perturbations in Long COVID (J Immunol)

Post-COVID immune system perturbations (J Immunol)

Systems disregulation in Long COVID (Sci Rep)

Clincal standards for diagnosing, treating, and preventing Long COVID (Intl J Tuberc Lung Dis)

Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

The post TWiV 1139: Long COVID with Dr. Judith Bruchfeld first appeared on This Week in Virology.

In his weekly clinical update, Dr. Griffin discusses the harms of perpetuating the lab leak hypothesis and the recent ACIP recommendations for the RSV vaccine for those individuals over 60, before reviewing the recent statistics on SARS-CoV-2 infection, treatment guidelines for the different phases of COVID, including vaccines, Pemgarda, early treatment with Paxlovid, remdesivir and molnupiravir, steroids at the right time, anticoagulation support, immune modulation in some cases, and a comprehensive definition of long COVID.

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Harms of the lab leak hypothesis (Journal of Virology)

Lab leak mania (PaulOffit, Substack)

This is a special message: pandemic started in nature! (TWiV)

RSV vaccine recommendations August 6 2024 (MMWR)

COVID-19 national trend (CDC)

COVID-19 deaths (CDC)

Where to get Pemgarda (Pemgarda)

CDC Quarantine guidelines (CDC)

Early phase of SARs-CoV-2 infection (COVID.gov)

NIH COVID-19 treatment guidelines (NIH)

Infectious Disease Society guidelines for treatment and management (ID Society)

Drug interaction checker (University of Liverpool)

Molnupiravir safety and efficacy (JMV)

Convalescent plasma recommendation for immunocompromised (ID Society)

Managing healthcare staffing shortages (CDC)

Steroids,dexamethasone at the right time (OFID)

Anticoagulation guidelines (hematology.org) Long COVID defined (NEJM)

Contribute to our Floating Doctors fundraiser

Lenacapavir on Puscast #60

Letters read on TWiV 1138

Dr. Griffin’s COVID treatment summary (pdf)

Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

The post TWiV 1138: Clinical update with Dr. Daniel Griffin first appeared on This Week in Virology.

TWiV discusses a twice-yearly antiviral for prevention of AIDS, the WHO pandemic plan, West Nile resurgence in the US, the BANAL SARS-CoV-2 related viruses reproduce in human cells but do not transmit among animal hosts, and an amino acid change in dengue virus that enhances midgut replication in mosquitoes but reduces pathogenicity in humans.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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PrEP with HIV-1 capsid inhibitor (NEJM)

WHO pandemic plan (pdf)

West Nile virus resurgence in US (NY Times)

Properties of BANAL SARS-CoV-2 like viruses (Nat Micro)

BANAL viruses on TWiV 809

Different effect of dengue virus amino acid change in humans and mosquitoes (Sci Transl Med)

Eng Ong Ooi on TWiV 633

Letters read on TWiV 1137

Timestamps by Jolene. Thanks!

Weekly Picks

Kathy – Using big data to improve traffic light timing
Rich – Dillo Dirt
Alan – Dueling Banjos on banjo and kora
Vincent – The world’s most expensive dinosaur and more

Listener Pick

Mike – Science through a glass darkly
Lisa – On A Mission“ Season Four

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

The post TWiV 1137: Dengue is not BANAL first appeared on This Week in Virology.

In his weekly clinical update, Dr. Griffin discusses how the pandemic may have affected our trust in physicians and hospitals and if waiting longer to make strain selection for the seasonal influenza vaccine would be advantageous before reviewing the recent statistics on SARS-CoV-2 infection, how different CVODI-19 vaccines effect the cardiovascular system, if the a third of either COVID-19 mRNA vaccine is effective, where to find PEMGARDA, if convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and the long term consequences of a SARS-CoV-2 infection on human health including incidences of diabetes, respiratory problems, hearing loss and maternal-fetal health.

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In physicians and hospitals, we trust (JAMA Network)

Are there benefits for delaying seasonal influenza vaccine selections (JID)

Personal protective effect for wearing surgical face masks in public spaces (the BMJ)

COVID-19 national trend (CDC)

COVID-19 deaths (CDC)

Cardiovascular safety of different COVID-19 vaccination(Nature Comm)

Effectiveness of a third dose of mRNA-1273 versus BNT162b2 among older adults (Vaccine)

Where to get pemgarda (Pemgarda)

CDC Quarantine guidelines (CDC)

Early phase of SARs-CoV-2 infection (COVID.gov)

NIH COVID-19 treatment guidelines (NIH)

Infectious Disease Society guidelines for treatment and management (ID Society)

Drug interaction checker (University of Liverpool)

Molnupiravir safety and efficacy (JMV)

Convalescent plasma recommendation for immunocompromised (ID Society)

Managing healthcare staffing shortages (CDC)

Steroids,dexamethasone at the right time (OFID)

Anticoagulation guidelines (hematology.org)

Incidence of diabetes after SARS-CoV-2 infection (The Lancet Diabetes & Endocrinology)

Post-COVID-19 respiratory sequelae two years after hospitalization (The Lancet Regional Health)

Incidence of hearing loss following COVID-19 among young adults (eClinical Medicine)

The effect of long-term COVID-19 infection on maternal and fetal complications (Scientific Reports)

Contribute to our Floating Doctors fundraiser

Letters read on TWiV 1136

Dr. Griffin’s COVID treatment summary (pdf)

Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

The post TWiV 1136: Clinical update with Dr. Daniel Griffin first appeared on This Week in Virology.

TWiV reviews whats going on with measles and its global resurgence, poliovirus found in Gaza, vaccine hesitancy in a community, 14 year old dies of Nipah, selection of SARS-CoV-2 viruses resistant to nirmatrelvir, and protective but non-neutralizing antibodies from survivors of Crimean-Congo hemorrhagic fever virus.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Brianne Barker, and Angela Mingarelli

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MicrobeTV Discord Server

What’s going on with measles? (J Virol)

Poliovirus in Gaza (Science)

Sanitation concerns in Gaza (AP)

Community vaccine beliefs (PLoS One)

14 year old dies of Nipah in India (Hindustan Times)

Selection of nirmatrelvir resistance mutants (Sci Adv)

CCHFV monoclonal antibodies (Cell Rep)

CCHFV vaccine (TWiV 565)

Prometheus Project (TWiV 578)

TWiV at USAMRIID (TWiV 1015)

Letters read on TWiV 1135

Timestamps by Jolene. Thanks!

Weekly Picks

Angela – Animal research is not always king
Brianne – Why the US has more tornadoes than any other country
Dickson – Earth’s core has slowed so much it’s moving backward
Alan – Article about the Smithsonian’s forensic ornithology lab, led by Carla Dove
Vincent – Seventh patient ‘cured’ of HIV: why scientists are excited

Listener Pick

Charles – An Inquiry into Morals by Robert M. Pirsig and My Beloved Monster by Caleb Carr

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

The post TWiV 1135: Resistance is not always futile first appeared on This Week in Virology.

In his weekly clinical update, Dr. Griffin discusses Merck’s RSV preventative monoclonal antibody Clesrovimab before reviewing the recent statistics on SARS-CoV-2 infection, if previous SARS-COV-2 infections predict the outcome of subsequent infections, if using COVID rapid diagnostic tests is cost effective, if the protein based vaccine NVX-CoV2327 elicits a durable immune response, if combination treatment of vaccine and antiviral drugs effectively protect against hospitalization, where to find PEMGARDA, what do when healthcare workers succumb to SARS-CoV-2 infection, and how COVID-19 may alter the cognitive trajectories of older patients.

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Clesrovimab, RSV preventative monoclonal antibody for infants (Merck)

COVID-19 national trend (CDC)

COVID-19 deaths (CDC)

Characterizing SARS-CoV-2 reinfections and long COVID (Communications Medicine)

Cost-effectiveness of COVID rapid diagnostic tests (PLoS Medicine)

NVX-CoV2373 against pre-Delta and Delta strains of COVID-19 little evidence of waning immune response (CID)

Combined Protection of Vaccination and Nirmatrelvir-Ritonavir Against Hospitalization(CID)

Pemgarda infusion center locator (Pemgarda)

Respiratory virus guidance (CDC)

Early phase of SARS-CoV-2 infection (COVID.gov)

NIH COVID-19 treatment guidelines (NIH)

Infectious Disease Society guidelines for treatment and management (ID Society)

Drug interaction checker (University of Liverpool)

Molnupiravir safety and efficacy (JMV)

Convalescent plasma recommendation for immunocompromised (ID Society)

What do when your heathcare provider is infected with SARS-CoV-2 (CDC)

Managing healthcare staffing shortages (CDC)

Steroids,dexamethasone at the right time (OFID)

Anticoagulation guidelines (hematology.org)

Cognitive trajectories in older survivors of COVID-19 up to 2.5 years post-infection(Nature Aging)

Contribute to our Floating Doctors fundraiser

Letters read on TWiV 1134

Dr. Griffin’s COVID treatment summary (pdf)

Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

The post TWiV 1134: Clinical update with Dr. Daniel Griffin first appeared on This Week in Virology.

TWiV reviews cases of measles in Brooklyn NY and Washington DC, stalling of global childhood vaccination, licenses H5N1 vaccines protect against circulating strains, viruses traveling without passports. OC43 SARS-CoV- 2 spike replacement virus as an improved BSL-2 proxy virus for SARS-CoV-2 neutralization assays, and deep mutational scanning reveals functional constraints and antibody-escape potential of Lassa virus glycoprotein complex.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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MicrobeTV Discord Server

Measles in Brooklyn NY (ABC)

Measles in Washington DC (DC Health)

Global childhood immunization stalls (WHO)

Licensed H5N1 vaccines protect against circulating strains (Nat Med)

Viruses moving without passports (European CDC)

OC42-SARS-CoV-2 replacement spike virus (PNAS)

Deep mutational scanning of Lassa virus glycoprotein (Immunity)

Letters read on TWiV 1133

Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Elemental sulfur found on Mars
Kathy – Lennette Lectures at ASV, including Gail Wertz, ASV 2024
Rich – Electricity maps (Opinions: Nuclear Waste Is Misunderstood; Should We Be Worried About Nuclear Waste?)
Alan – Nature sent an investigative reporter to a predatory conference
Vincent – Coal-filled trains are likely sending people to the hospital

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

The post TWiV 1133: Gain of function makes us safer first appeared on This Week in Virology.

In his weekly clinical update, Dr, Daniel Griffin reviews President Biden’s case of COVID, reviews recent statistics on SARS-CoV-2 infection, discusses post-acute sequelae after infection during pregnancy, the use of nirmatrelvir-ritonavir for post-exposure prophylaxis, where to find Pemgarda, effectiveness of combined nirmatrelvir-ritonavir-molnupiravir treatment, effectiveness of Ensitrelvir in reducing severe outcomes in outpatients at high risk for COVID-19, effectiveness of combined nirmatrelvir-ritonavir-molnupiravir treatment in patients hospitalized with COVID-19, CDC update of Long COVID Basics page, postacute sequelae of SARS-CoV-2 infection in the pre-delta, delta, and omicron eras, Long COVID risk has dropped over time but remains substantial, efficacy of antivirals, corticosteroids, and mAbs as acute COVID treatments in reducing the incidence of long COVID, and the interplay between diet and the gut microbiome: implications for health and disease.

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Links for this episode

President Biden has COVID (CNN, USA Today)

COVID-19 national trend (CDC)

COVID-19 deaths (CDC)

Post–acute sequelae of COVID after infection during pregnancy (OB & Gyn)

Oral nirmatrelvir–ritonavir as postexposure prophylaxis for Covid-19 (NEJM)

Pemgarda infusion center locator (Pemgarda)

Unable to access pemgarda, gotta call Daniel (microbeTV)

CDC Quarantine guidelines (CDC)

Early phase of SARs-CoV-2 infection (COVID.gov)

NIH COVID-19 treatment guidelines (NIH)

Infectious Disease Society guidelines for treatment and management (ID Society)

Drug interaction checker (University of Liverpool)

Combined treatment of COVID reduces molnupiravir-induced mutagenicity (J Inf Dis)

Effectiveness of ensitrelvir in reducing severe outcomes in outpatients at high risk for COVID-19 (Inf Dis Therapy)

Comparative effectiveness of combination therapy with nirmatrelvir–ritonavir and remdesivir versus monotherapy (Lancet)

Molnupiravir safety and efficacy (JMV)

Convalescent plasma recommendation for immunocompromised (ID Society)

Isolation guidance (CDC)

Managing healthcare staffing shortages (CDC)

Steroids, dexamethasone at the right time (OFID)

Anticoagulation guidelines (hematology.org)

Long COVID is defined (National Academies)

Long COVID: the ANSWERS! (longcovidtheanswers.com)

The FACTS: post COVID-19=long COVID? (WHO)

The BASICS of long COVID-19 (CDC)

Postacute sequelae of SARS-CoV-2 infection in the pre-delta, delta, and omicron eras (NEJM)

Long Covid risk has dropped over time but remains substantial (CNN)

Efficacy of antivirals, corticosteroids, and mAbs as acute COVID treatments in reducing the incidence of long COVID (Clin Micro Inf)

Diet and the gut microbiome: implications for health and disease (Nat Rev Micro)

Contribute to our Floating Doctors fundraiser

Letters read on TWiV 1132

Dr. Griffin’s COVID treatment summary (pdf)

Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

The post TWiV 1132: Clinical update with Dr. Daniel Griffin first appeared on This Week in Virology.

TWiV reviews the potential impact on science of the Supreme Court ruling in the Chevron decision, measles in New Hampshire and Vermont, new who proposed terminology for respiratory pathogen transmission, and pathogenicity and transmission of bovine H5N1 influenza virus.

Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit

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MicrobeTV Discord Server

Articles on Chevron decision (one, two, three)

Measles in New Hampshire and Vermont (NH DHHS)

Pathogenicity and transmission of bovine H5N1 virus (Nature)

Letters read on TWiV 1131

Timestamps by Jolene. Thanks!

Weekly Picks

Dickson – Stockholm Wood City
Rich – “The Wide Wide Sea” by Hampton Sides
Vincent – Tour de France stage 12

Listener Picks

Amy – Earth Forced from the Protective Heliosphere: What Do We know?

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

The post TWiV 1131: Mootant influenza H5N1 virus first appeared on This Week in Virology.

In his weekly clinical update, Dr. Griffin discusses H5N1 influenza in the bird and cow communities of Colorado and Michigan and dengue in New York and the US before reviewing the recent statistics on SARS-CoV-2 infection, the absence of association with proton pump inhibitors and COVID-19 severity in children, where to find PEMGARDA, the effectiveness of molnupiravir and dexamethasone, convalescent plasma, what to do when healthcare workers succumb to SARS-CoV-2 infection, a resource of long COVID answers, how the WHO and CDC define long COVID and how it compares to ME/CSF.

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Links for this episode

H5N1: birds and cows oh, my…..Michigan and Colorado (CIDRAP)

Flu pandemic for the Colorado chicken (Colorado Sun)

It’s a disaster: Avian flu in Weld county (Colorado.gov)

More 9.7 million dengue cases in US this year: CDC issues warning (Patch.com)

Long Island has DENGUE! (Long Island News12)

COVID-19 national trend (CDC)

COVID-19 deaths (CDC)

Association between proton pump inhibitors and COVID-19 susceptibility or severity in children? (Journal of Pediatrics)

Where to get pemgarda (Pemgarda)

Unable to access pemgarda, gottacall Daniel (microbeTV)

CDC Quarantine guidelines (CDC)

Early phase of SARs-CoV-2 infection (COVID.gov)

NIH COVID-19 treatment guidelines (NIH)

Infectious Disease Society guidelines for treatment and management (ID Society)

Drug interaction checker (University of Liverpool)

Molnupiravir safety and efficacy (JMV)

Convalescent plasma recommendation for immunocompromised (ID Society)

What do when your heathcare provider is infected with SARS-CoV-2 (CDC)

Managing healthcare staffing shortages (CDC)

Steroids,dexamethasone at the right time (OFID)

Benefits of desamethasone, reversal of monocyte dysfunction for severe COVID-19 (Cell)

Anticoagulation guidelines (hematology.org)

Long COVID: the ANSWERS! (longcovidtheanswers.com)

The FACTS: post COVID-19=long COVID? (WHO)

The BASICS of long COVID-19 (CDC)

Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness (CDC)

Contribute to our Floating Doctors fundraiser

Letters read on TWiV 1130

Dr. Griffin’s COVID treatment summary (pdf)

Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

The post TWiV 1130: Clinical update with Dr. Daniel Griffin first appeared on This Week in Virology.