A TWiV duo reviews how SARS-CoV-2 attacks the olfactory mucosa but spares the olfactory bulb, vaccination with BNT162b2 induces virus-specific stem cell memory T cells, and development of an oral protease inhibitor for the treatment of COVID-19.
Hosts: Vincent Racaniello and Brianne Barker
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Download TWiV 829 (67 MB .mp3, 112 min)
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Links for this episode
- How SARS-CoV-2 attacks olfactory mucosa (Cell) 3:00
- SARS-CoV-2-specific stem cell memory T cells after mRNA vaccine (Sci Immunol) 20:21
- Oral SARS-CoV-2 protease inhibitor (Science) 50:40
- Paxlovid phase 2/3 trial preliminary results (Pfizer) 1:13:27
- Letters read on TWiV 829 1:16:08
- Timestamps by Jolene. Thanks!
Weekly Picks 1:29:29
Brianne – Coronavirus Neutralizing Antibodies and mRNA Vaccine Video
Vincent – MHC restriction of cytotoxic T cell lysis (Nobel description)
Lisa – Shall Furnish Medicine
Bistra – Saving the World by Julia Alvarez
Intro music is by Ronald Jenkees
Send your virology questions and comments to firstname.lastname@example.org
On the question about incorrect intramuscular application:
The real question was not raised, and you didn’t mention the most probable malaplication: Inadvertent intravenous. There are concerns that that might be the mechanism behind the cases of myocarditis: distributing the vaccine quickly to loci where you definitely DON’T want the initial inflammation to occur.
It’s easy to avoid inadvertent intravenous application: aspiration. Withdraw the plunger of the syringe briefly before injection to check if you draw blood.
This is a common practice for IM applications, but for some reason in their immesurable wisdom the powers that be advise AGAINST aspiration in the case of this vaccine. In the process missing an opportunity to apply best practice and improve trust in the procedures.
Heard you talking about doing peptide pools study for $100,000, and saying it is enormously expensive.
It’s not quite the same price of one hellfire missile, like the one that which killed that aid worker, with his trunk full of water, and his family in Afghanistan.
One needs wonder about priorities and politics of the empire, which cannot be rationally ignored. I would like to not have to think about the war industry connections but I can’t quite manage it.
Great episode with Brianne! I love to hear you discuss immunology. Some of this science and terminology was a little over my head which means I may have to listen to this a few times and do a little research to understand it but I like having this kind of homework!
Brianne is such a great inspiration! I love her enthusiasm and the way she explains complicated immune functions! She is such a gem!!
It would have been great if you could have had your wife on this episode! Her experience and expertise would have added a great element to the discourse! Maybe she can make another guest appearance on TWiV in the near future. With all of the news on antivirals she would be a great guest.
Thanks again for the Inspiration!
Sincerely a serious TWiV lover, and Your biggest fan in Rhode Island,