A TWiV trio reveals the 100 million year old history of bornavirus infections hidden as EVEs in vertebrate genomes, and identification of novel bat coronaviruses that provide evolutionary insight into the origins of SARS-CoV-2.
Hosts: Vincent Racaniello, Alan Dove, and Amy Rosenfeld
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Download TWiV 771 (68 MB .mp3, 114 min)
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Links for this episode
- ASV Vaccine Town Hall 1:11
- 100 million year old bornavirus infections (PNAS) 5:22
- Bornaviruses across geological timescales (PNAS) 6:41
- Bornaviruses previously on TWiV 303, 347, 548 6:53, 9:51
- Novel bat SARS-CoV-2 related coronaviruses (Cell) 31:49
- Letters read on TWiV 771 1:01:52
- Timestamps by Jolene. Thanks!
Weekly Picks 1:37:48
Amy – A relic from the Jurassic era
Alan – World of Wonders, by Aimee Nezhukumatathil
Vincent – Tom Buck’s YouTube Channel
Victor – Vaccines: A measured response
Intro music is by Ronald Jenkees
Send your virology questions and comments to firstname.lastname@example.org
Great to see Amy again.
I’m more of a Twimmer than a Twivver, I work on infectious diseases (bacterial and viral), in particular on enzymes. I’ve worked on botulinum neurotoxin and an enzyme from B. anthracis. I recently started to work on viral proteases and I noticed that these proteases recognize several host protein sequences, and can cut them. Some of them appear to be related to the symptoms. As an enzymologist, ‘nonstructural protein’ seems a bit dismissive. While a microbiologist would not deny that a bacterial protease could be a “toxin”, the response I’ve received in associating viral proteases with toxicity are completely different. If viral proteases are responsible for some of the observed symptoms, as a virologist/microbiologist familiar with both sides, what would you call these proteases? Would you label them a “toxin”??