TWiV examines the claim by Brazil’s ANVISA that the Sputnik vaccine contains replication-competent adenovirus, and a role for the furin cleavage site in SARS-CoV-2 spike for efficient reproduction in the respiratory tract, evasion of antiviral IFITM proteins, and transmission in ferrets.
Hosts: Vincent Racaniello, Rich Condit, and Kathy Spindler
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Download TWiV 751 (78 MB .mp3, 83 min)
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Links for this episode
- ASV vaccine town halls 3:15
- Brazil rejects Gamaleya vaccine (Sci Transl Med) 5:07
- Russian vaccine behavior (Sci Transl Med) 5:13
- Is Gamaleya vaccine safe? (Science) 28:29
- Furin cleavage site in replication and transmission (Nat Micro) 35:02, 43:04
- Furin site loss attenuates pathogenesis (Nature) 42:12
- Timestamps by Jolene. Thanks!
Weekly Picks 1:22:29
Rich – The diversity and function of sourdough starter microbiomes; Dunn Lab Wild Sourdough Project
Kathy – ISS, Crew Dragon, and the sun Doubly warped world of binary black holes
Vincent – Mr. Labman
Listener Picks
Joy – Abandoned America: Matthew Christopher’s Autopsy of the American Dream
Intro music is by Ronald Jenkees
Send your virology questions and comments to [email protected]
What’s the link to Rich’s video about virus, immunity, and whatever else he said was essential to understand the great explanation he and Kathy gave about the adenovirus vector? Great show BTW! Thank you!
Dear Dr. Racaniello,
I have two question that I cannot find satisfying answer, and I was wondering if you can touch on them in some next episode.
1. What are the impact of pseudouridinylation on the translational machinery, and the subsequent localization to the ER-Golgi-membrane as well as the UPR and the reshuffling of gene expression that goes along the UPR signaling pathways? it as threatening? https://www.pnas.org/content/116/46/23068
2. A recent paper showed that the spike protein itself is damaging, wouldn’t be counterintuitive to use the spike protein for vaccine? https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.121.318902
Hey everyone,
I was listening to this episode about Anvisa (Brazilian FDA) not pushing through the emergency use of Sputnik. I thought you might be interested in this episode of Explaining Brazil: Vaccine diplomacy in Latin America. There are two interviews that I thought was interesting, one with Dr. Flavio de Fonseca (current president of Brazilian Virology Society) and one with David Fidler (senior fellow for global health and cybersecurity at the Council on Foreign Relations)
https://brazilian.report/podcast/2021/05/05/vaccine-diplomacy-in-latin-america/
Thanks for this podcast and for using it to teach, discuss and share ideas with all of us.
Cheers,
Isabel
Please correct the link to the profile of Rich Condit. It shall be as follows: http://mgm.ufl.edu/profile/condit-rich/