TWiV 714: The shape of spike with Jason McLellan

January 31, 2021

Jason McLellan joins TWiV to reveal all we know about the SARS-CoV-2 spike protein, followed by Novavax and J&S phase 3 results and a discussion of variants of concern: neutralization by vaccine-induced antibodies, transmission, and virulence.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld

Guest: Jason McLellan

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Download TWiV 714 (76 MB .mp3, 127 min)
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Links for this episode

Weekly Picks 1:53:21

DicksonPandemic Pivot and Tuba Skinny
AlanTechnological challenges in vaccine rollout
RichI was lucky to find this vaccine anywhere
VincentLady Gaga’s MIXED METER Star Spangled Banner?!

Intro music is by Ronald Jenkees

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3 comments on “TWiV 714: The shape of spike with Jason McLellan

  1. This show harkens back to TWiV 697 and 700 where Rich defended Genomic Epidemiology as Science. These papers from Nerve tag are not science in the sense of Karl Popper but certainly are in the spirit of John Snow. It is fodder for further work.

    The Stanley Plotkin article is inspirational. It reminds me of Maurice Hillieman. The Vaccinologists of our youth are heroes. Science was seen in those times as progress. We owe so much to those progressive women and families who offered up their own children for science.

    The quote struck me from the Plotkin article.

    “Our vaccine development has been remarkable. There are many reasons for doom and gloom, but the science is sustaining.”

    Good stuff. We are lucky to live in these times in many ways.

    Great show. Lots to think about here. Here’s to a declining cases, shots and jabs.

  2. Rob Miller Feb 1, 2021

    The Janet Iwasa lab animation mentioned at 17:48 is beautiful and can be found at