Jason McLellan joins TWiV to reveal all we know about the SARS-CoV-2 spike protein, followed by Novavax and J&S phase 3 results and a discussion of variants of concern: neutralization by vaccine-induced antibodies, transmission, and virulence.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Amy Rosenfeld
Guest: Jason McLellan
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Download TWiV 714 (76 MB .mp3, 127 min)
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Links for this episode
- Prefusion spike structure (Science) 3:27, 10:29
- Neutralization of VOC by vaccine induced antibodies: Moderna and Pfizer 57:48
- Novavax COVID-19 vaccine phase 3 results (Novavax) 1:15:41
- J&J COVID-19 vaccine phase 3 results (J&J) 1:27:48
- B.1.1.7 has been in the US since November 2020 (virological.org) 1:37:27
- NERVTAG report on B.1.1.7 virulence (pdf) 1:46:57
- Timestamps by Jolene. Thanks!
Weekly Picks 1:53:21
Dickson – Pandemic Pivot and Tuba Skinny
Alan – Technological challenges in vaccine rollout
Rich – I was lucky to find this vaccine anywhere
Vincent – Lady Gaga’s MIXED METER Star Spangled Banner?!
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
This show harkens back to TWiV 697 and 700 where Rich defended Genomic Epidemiology as Science. These papers from Nerve tag are not science in the sense of Karl Popper but certainly are in the spirit of John Snow. It is fodder for further work.
The Stanley Plotkin article is inspirational. It reminds me of Maurice Hillieman. The Vaccinologists of our youth are heroes. Science was seen in those times as progress. We owe so much to those progressive women and families who offered up their own children for science.
The quote struck me from the Plotkin article.
“Our vaccine development has been remarkable. There are many reasons for doom and gloom, but the science is sustaining.”
Good stuff. We are lucky to live in these times in many ways.
Great show. Lots to think about here. Here’s to a declining cases, shots and jabs.
You guys need to wake up
https://www.google.com/amp/s/buffalonews.com/news/local/unapproved-by-fda-ivermectin-useful-as-covid-19-treatment-local-doctors-say/article_8ee56f1a-625d-11eb-b771-b76fa82cbedb.amp.html
The Janet Iwasa lab animation mentioned at 17:48 is beautiful and can be found at https://insidecorona.net/sars-cov-2-entry-animation-from-iwasa-group-a-little-christmas-present-to-the-scientific-community/