From ASV 2022 in Madison, Wisconsin, TWiV speaks with Pamela Bjorkman and Andy Mehle about their careers and their research on influenza virus, HIV-1, SARS-CoV-2, and influenza virus.
TWiV 875: Animal house
- March 13, 2022
- Tagged as: ACE2, animal reservoir, COVID-19, pandemic, receptor binding domain, SARS-CoV-2, viral, virology, virome, virus, viruses, wildlife, zoonosis
TWiV discusses the virome of game animals in China, and the finding that binding of sarbecoviruses to ACE2 is an ancestral and evolvable trait.
TWiV reveals isolation from bats in Laos of a SARS-CoV-2 like virus with a spike protein that allows entry into human cells, and exploration of a herpesvirus vector for immunization of vampire bats against rabies virus.
TWiV 757: Supershedders and super vaccines
- May 20, 2021
- Tagged as: coronavirus, COVID-19, nanoparticle, pandemic, receptor binding domain, RT-PCR, SARS-CoV-2, shedding, sortases, superspreader, Vaccine, viral, virology, virus, viruses
TWiV reveals that 2% of SARS-CoV-2−positive individuals carry 90% of the virus circulating in a college campus, and a nanoparticle vaccine that induces cross-reactive immunity against multiple pandemic and pre-emergent coronaviruses.
TWiV 588: Coronavirus update – Save the pangolin!
- February 23, 2020
- Tagged as: ACE2, China, coronavirus, CoV, COVID-19, epidemic, evolution, furin, pangolin, pneumonia, receptor binding domain, respiratory aerosol, SARS-CoV-2, spike glycoprotein, viral, virology, virus, viruses, Wuhan, zoonosis
The TWiV team returns this week to SARS-CoV-2019 coverage to review the latest epi curves, the fatality rate, furin cleavage site and receptor binding domain in the spike glycoprotein, related CoV recovered from pangolins, evidence that the virus did not escape from a laboratory, and many more questions sent in by listeners.