Recording together for the first time, the TWiV team celebrates their 300th podcast at the American Society for Microbiology headquarters in Washington, DC, where Vincent speaks with Dickson, Alan, Rich, and Kathy about their careers in science.

Vincent, Alan, Dickson and Rich answer listener questions about XMRV, yellow fever vaccine, virus-like particles, West Nile virus, amyotrophic lateral sclerosis and human endogenous retroviruses, multiplicity of infection, and how to make a poxvirus.

Vincent, Alan, and Rich explore a novel bunyavirus isolated in China, the recent polio outbreak in Republic of the Congo, and cell to cell transmission of a retrovirus by biofilm-like extracellular assemblies.