Tag: mutation

• Episodes
• Netcast

TWiV 697: The sky is NOT falling

• December 24, 2020
• Tagged as: aav, ACE2 receptor, coronavirus, COVID-19, mutation, Orf8, pandemic, SARS-CoV-2, spike protein, transmission, UK variant, variant of concern, viral, virology, virus, viruses, VOC202012/01

TWiV reviews the latest data on the UK variant of SARS-CoV-2, including some properties of the variant and why it is being closely studied, development of liver cancer in a participant in a adenovirus-associated virus gene therapy trial, and answers to listener questions.

• Episodes
• Netcast

TWiV 664: TWiV is for the dogs

• September 17, 2020
• Tagged as: common cold, coronavirus, COVID-19, D614G, immunity, mutation, pandemic, reinfection, SARS-CoV-2, viral, virology, virus, viruses

On this mid-week edition, does it matter that SARS-CoV-2 is mutating, seasonal coronavirus immunity is short-lived, another bogus claim that the virus was produced in a laboratory (it came from Nature), and answers to listener questions.

• Episodes
• Netcast

TWiV 619: Recombination led to emergence of SARS-CoV-2

• May 27, 2020
• Tagged as: bat CoV, computational biology, coronavirus, CoV, COVID-19, mutation, pandemic, recombination, SARS-CoV-2, spillover, viral, virology, virus, viruses, zoonosis

Raul Rabadan joins TWiV to explain the use of computational biology to demonstrate how recombination and mutation led to emergence of SARS-CoV-2.

• Episodes

TWiV 431: Niemann-Pick of the weak

• March 5, 2017
• Tagged as: arthropod, bacteriophage, cytoplasmic incompatibility, ebolavirus, glycoprotein, mutation, Niemann-Pick C1, prophage, selection, transmission, viral, virology, virus, WO, wolbachia

The TWiVirions reveal bacteriophage genes that control eukaryotic reproduction, and the biochemical basis for increased Ebolavirus glycoprotein activity during the recent outbreak.

• Netcast

TWiV 415: Ebola pipettors and the philosopher’s clone

• November 13, 2016
• Tagged as: adaptation, amino acid, ebola virus, filovirus, glycoprotein, mutation, NPC1, spillover, viral, virology, virus, viruses, zoonosis

Jeremy, Aaron, and Ted join the TWiV team to discuss their work on identifying a single amino acid change in the Ebola virus glycoprotein from the West African outbreak that increases infectivity in human cells.

• Netcast

TWiV 360: From Southeastern Michigan

• October 25, 2015
• Tagged as: Adam Lauring, Akira Ono, BK virus, error threshold, evolution, gain of function, GOF, hiv-1, michael imperiale, mutation, NSABB, polyomavirus, quasispecies, retrovirus, Southeastern Michigan, swarm, University of Michigan, viral, virology, virus, virus assembly

Vincent visits the University of Michigan where he and Kathy speak with Michael, Adam, and Akira about polyomaviruses, virus evolution, and virus assembly, on the occasion of naming the department of Microbiology & Immunology a Milestones in Microbiology site.

• Netcast

TWiV 340: No shift, measles

• June 7, 2015
• Tagged as: antigenic variation, backyard, biolabs, bsl3, bsl4, camel, coronavirus, influenza virus, measles virus, MERS-CoV, mutagenesis, mutation, outbreak, Richard Elliott, serosurvey, transposon, viral, virology, virus

The TWiV teams reviews a MERS-coronavirus serosurvey and an outbreak in South Korea, and constraints on measles virus antigenic variation.

• Netcast

TWiV 335: Ebola lite

• May 3, 2015
• Tagged as: aerosol, airborne, ebolavirus, evolution, funding, going aerosol, grants, mutation, NIH, Osterholm, research, transmission, Vaccine, viral, virology, virus, VP30

The TWiVumvirate discusses a whole Ebolavirus vaccine that protects primates, the finding that Ebolavirus is not undergoing rapid evolution, and a proposal to increase the pool of life science researchers by cutting money and time from grants.

• Netcast

TWiV 332: Vanderbilt virology

• April 12, 2015
• Tagged as: antibodies, bacteriophage, coronavirus, ebolavirus, endosymbiont, error correction, evolution, influenza virus, MERS, mutation, neutralization, SARS, viral, virology, virus, wolbachia

Vincent visits Vanderbilt University and meets up with Seth, Jim, and Mark to talk about their work on a virus of Wolbachia, anti-viral antibodies, and coronaviruses.

• Netcast

TWiV 302: The sky is falling

• September 14, 2014
• Tagged as: aerosol transmission, bsl3, bsl4, containment, ebola virus, enterovirus D68, hemorrhagic fever, mutation, outbreak, picornavirus, respiratory disease, Vaccine, viral, virology, virus, West Africa

The TWiVers discuss the growing Ebola virus outbreak in West Africa, and an epidemic of respiratory disease in the US caused by enterovirus D68.