The TWiVsters explain how the shape of pleomorphic virus particles – spherical or filamentous – determines the probability of virus attachment and fusion, and resistance to selective pressure such as antibodies that block cell entry.
On a TWiV tetramer, we review the ongoing outbreaks of Ebolavirus disease in DRC and Guinea, evidence that SARS-CoV-2 infections in children are far more prevalent than are being detected, and recent long COVID estimates from the UK.
Gisa, Steffi, and César join TWiV to discuss their careers, their research, and the COVID-19 pandemic in Germany.
From Georgia State University, Vincent speaks with Chris, Andrew, Priya, and Richard about their careers and their work on Ebolaviruses, rotavirus, and antiviral drug development.
Daniel Griffin provides a clinical update on COVID-19, including analysis of the dexamethasone trial, and then we discuss two Ebolavirus outbreaks in DRC, clinical and virological aspects of asymptomatic SARS-CoV-2 infections, age-dependent effects on transmission, and answer listener email.
TWiV 625: Fred Murphy, virologist for all seasons
- June 11, 2020
- Tagged as: ebolavirus, Fred Murphy, histopathology, Lassa virus, Marburg virus, rabies virus, viral, virology, virology history, virus, viruses
Vincent and Rich visit Fred Murphy to hear about his wide-ranging career in virology, spanning many institutions, involving dangerous viruses like rabies virus, Ebolavirus (he took that famous iconic image), Marburg virus, Lassa virus, coronaviruses, and later writing a history of the field.
TWiV 612: CEPI, preventing the next pandemic
- May 12, 2020
- Tagged as: CEPI, ebolavirus, Hendra virus, Nipah virus, pandemic, SARS-CoV, Vaccine, vaccine platform, viral, virology, virus, viruses
From the Nipah Virus International Conference in Singapore, Vincent speaks with Richard Hatchett, CEO of CEPI, about its mission to stimulate and accelerate the development of vaccines against emerging infectious diseases.
Vincent and Rich travel to Galveston National Laboratory to speak with Jim LeDuc, Tom Ksiazek, and Bob Tesch about their long careers as virus hunters.
TWiV 561: Hot or not
- August 18, 2019
- Tagged as: bat, ebolavirus, inflammation, monoclonal antibody, mutualism, NLRP3, panic grass, reservoir host, symbiosis, thermotolerance, viral, viroloy, virus, viruses
The Autonomous CollecTWiVe reveal two effective treatments for Ebolavirus infection, how a virus in a fungus confers heat tolerance to a plant, and dampened inflammation as a mechanism for bat tolerance to viral infection.
TWiV 542: Inside Microbiotix
- April 7, 2019
- Tagged as: adenovirus, biotech, cytomegalovirus, ebolavirus, herpesvirus, influenza, Lassa virus, Microbiotix, small molecule drugs, viral, virology, virus, viruses
Vincent travels to Microbiotix, Inc, a biopharmaceutical company in Worcester, MA to speak with four members of the company about their discovery and development of small molecule drugs that target serious infectious diseases.