fungal christmas treeHosts: Vincent Racaniello, Dickson DespommierRich Condit, and Alan Dove

Vincent, Dickson, Rich, and Alan review the 100 year old finding by Peyton Rous of a transmissible sarcoma of chickens, a discovery that ushered in the era of tumor virology.

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Rich – The Log from the Sea of Cortez by John Steinbeck
AlanComet rise
Vincent – TWiV iPhone case

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Ronnie – How fungi celebrate Christmas
Kevin – EcoCyc app
Gabriel –
ImmGen app

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Hosts: Vincent Racaniello, Rich Condit, and Alan Dove

Vincent, Rich, and Alan continue Virology 101 with a discussion of transcription, the process of making mRNA from a DNA template.



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Rich – 3D vaccinia virion
AlanHappy Holidays from NOAA (YouTube)
Vincent – 17 year old wins $100,000 science prize

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SarahCritical Thinking (pdf),  diagnosing respiratory infections by gene signature (Cell Host Micro), and One Health Initiative (CDC page)

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transcription

antibodyHosts: Vincent Racaniello, Rich ConditAlan Doveand Gabriel Victora

Vincent, Rich, Alan and Gabriel review the production of antibodies by B cells, and how high affinity antibodies are selected in the germinal centers of lymph nodes.

Click the arrow above to play, or right-click to download TWiV 161 (71 MB .mp3, 118 minutes).

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Gabriel – Antibody-based protection against HIV (Nature)
Rich – Contact
AlanFlu shot dystonia (YouTube)
Vincent – Sciflies and RocketHub

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NevaVirus and retrovirus
AyeshaThe Life Scientific (BBC)

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merkel carcinomaHosts: Vincent Racaniello, Rich ConditAlan DoveDickson Despommier, and Patrick Moore

The TWiV team speaks with Patrick Moore about his discovery, with Yuan Chang, of two human tumor viruses, Kaposi’s sarcoma herpesvirus and Merkel cell polyomavirus.

Click the arrow above to play, or right-click to download TWiV 160 (66 MB .mp3, 109 minutes).

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Patrick – The Theory That Would Not Die by Sharon Bertsch McGrayne
Dickson –
Foodborne illness acquired in the US (Emerging Inf Dis)
Rich – GATTACA
AlanCutting for Stone by Abraham Verghese
Vincent – Boxwave capacitative stylus

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Neva10+1 top science apps
RicardoWhere’s the outrage?

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ferretHosts: Vincent RacanielloAlan Dove, and Rich Condit

Vincent, Alan, and Rich review concern over an influenza H5N1 transmission experiment, and a new host defense protein against RNA viruses.

Click the arrow above to play, or right-click to download TWiV 159 (48 MB .mp3, 80 minutes).

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Rich – Livescribe Smartpen
Alan – Royal Society journal archive
Vincent – Chronic fatigue syndrome and the CDC by Dave Tuller

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JudiTop 7 in Microbiology

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poliovirus + CD155Hosts: Vincent RacanielloRich Condit, Alice Telesnitsky, and Kathy Spindler

Vincent and Rich visit the Microbiology and Immunology Department at the University of Michigan Medical School, and speak with Alice and Kathy about their work on HIV genome dimerization, and packaging and pathogenesis of mouse adenovirus.

Model of poliovirus bound to CD155 made by Stefan Taube.

Click the arrow above to play, or right-click to download TWiV 158 (52 MB .mp3, 87 minutes).

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Alice – Banvard’s Folly by Paul S. Collins
Kathy – The world at seven billion
RichThe Princess Bride
Vincent – Center for the history of microbiology

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TimDead Ends to Somewhere by Richard L. Ward
DonBen Goldacre: Battling bad science (TED)

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dendritic cellHosts: Vincent RacanielloRich Condit, Alan Dove, Dickson Despommier, Jeremy Luban, and Gabriel Victora

A large TWiV panel remembers Ralph Steinman, and considers a new innate sensor of retroviral capsids.

Photograph of a dendritic cell (green) interacting with T cells (cyan) near a blood vessel by Gabriel Victora.

Click the arrow above to play, or right-click to download TWiV 157 (90 MB .mp3, 125 minutes).

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Dickson – Eats, Shoots & Leaves by Lynne Truss
Rich – Battlestar Galactica
AlanColeman LED quad lantern
GabrielA History of Immunology by Arthur M. Silverstein
JeremyPrinciples of Virology by Flint, Enquist, Racaniello, Skalka
Vincent – Principles of Molecular Virology by AJ Cann

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DavidCarl Sagan’s Pale Blue Dot (YouTube)

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jx-594Hosts: Vincent RacanielloRich Condit, and Dickson Despommier

Vincent, Rich, and Dickson review a meta-analysis on influenza vaccine, a killer virus in fungi that selects against RNAi, and the use of armed and targeted poxviruses for oncolytic virotherapy.

Click the arrow above to play, or right-click to download TWiV 156 (57 MB .mp3, 94 minutes).

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Rich – Google’s self-driving car (story one and two)
DicksonWild Russia and Wild China TV series
Vincent – Baculovirus molecular biology by George Rohrmann (free)

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JimLee Cronin: Making matter come alive (TED)

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sbv_logoenv2011Hosts: Vincent Racaniello, Grant McFadden, Eurico de Arruda Neto, Paulo Eduardo Brandão, Francisco Murilo Zerbini, and Janice Reis Ciacci Zanella

Vincent, Grant, Eurico, Paulo, Francisco and Janice discuss their work on bocavirus, infectious bronchitis virus, begomoviruses, and circoviruses at the Brazilian Virology Society meeting in Atibaia, São Paulo, Brazil.

Click the arrow above to play, or right-click to download TWiV 155 (56 MB .mp3, 93 minutes).

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Vincent – AAM Colloquium Program
Grant – The Disappearing Spoon by Sam Kean

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Antonio2011 Nobel Laureates Lectures at Lindau

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mmtvHosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich are very enthusiastic about two studies that show how gut bacteria help viral invaders.

Click the arrow above to play, or right-click to download TWiV 154 (46 MB .mp3, 77 minutes).

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Alan – SciWriteLabs
Vincent – Take as directed

Listener Pick of the Week

TonyIntroduction to AI online course

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