TWiV 99: ICAAC Boston 2010

Host: Vincent Racaniello

On episode 99 of the podcast This Week in Virology, Vincent tours the 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in Boston, speaking with exhibitors and visitors, including Professors Derek Smith, Michael Schmidt, Frederick Hayden, and Myra McClure.

Many thanks to Chris Condayan and Ray Ortega of the American Society for Microbiology for recording and editing this episode.



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TWiV 98: Murine musings, electric shirts, and rabid pathologists

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich review the finding of murine leukemia virus-related sequences in the blood of CFS patients and healthy donors, laboratory inventories for wild poliovirus containment, weaving high-performance viral batteries into fabric for the military, and a case of human rabies in Indiana.

Click the arrow above to play, or right-click to download TWiV #98 (58 MB .mp3, 80 minutes)

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Weekly Science Picks

Alan – NCBI ROFL
Rich – The Great Bridge by David McCullough
Vincent – Dr. Rous’ Prize-Winning Chicken

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TWiV 97: California virology

Hosts: Vincent Racaniello, Peter Sarnow, and Bert Semler

During a trip to California, Vincent visited Peter Sarnow and Bert Semler and spoke with them about their work on internal ribosome entry, and the requirement for a cellular microRNA for hepatitis C virus replication.

Click the arrow above to play, or right-click to download TWiV #97 (66 MB .mp3, 91 minutes)

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Links for this episode:

  • Eukaryotic mRNAs that might contain an IRES (PNAS)
  • Modulation of HCV RNA abundance by a liver-specific microRNA (Science)
  • Viral small RNAs (PLoS Pathogens)
  • Bridging IRES elements to the translation apparatus (Biochim Biophys Acta)
  • A nucleo-cytoplasmic SR protein functions in viral IRES mediated translation (EMBO J)
  • Nuclear vs cytoplasmic routes to IRES mediated translation (Trends in Microbiology)
  • Letter read on TWiV 97

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TWiV 96: Making viral DNA

Hosts: Vincent Racaniello, Dickson Despommier, and Rich Condit

Vincent, Dickson, and Rich continue Virology 101 with a discussion of how viruses with DNA genomes replicate their genetic information.



Click the arrow above to play, or right-click to download TWiV #96 (65 MB .mp3, 90 minutes)

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Weekly Science Picks

Rich – Breast milk sugars give infants a protective coat (NY Times and PNAS article)
 Vincent – The Great American University by Jonathan R. Cole

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TWiV 95: Does a virus shift in the woods?

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

Vincent, Dickson, Alan, and Rich consider the end of the influenza H1N1 pandemic, dengue in Florida, vaccinia virus infection in Brazilian monkeys, and viruses in the faecal microbiota.

Click the arrow above to play, or right-click to download TWiV #95 (68 MB .mp3, 94 minutes)

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Weekly Science Picks

Alan – Families Fighting Flu
Rich – Food, Inc.
Dickson –  Fuel
Vincent – MIT Open Courseware
Michael –  Waiting for Superman and Can Science Feed the World? (Nature)

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TWiV 94: XMRV with Dr. Ila Singh

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Ila Singh

Vincent, Alan, and Rich speak with Ila Singh about the new human retrovirus XMRV, and how her laboratory is studying its association with prostate cancer and chronic fatigue syndrome.

Click the arrow above to play, or right-click to download TWiV #94 (56 MB .mp3, 77 minutes)

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Weekly Science Picks

Alan – The new Federal Register site (see also regulations.gov)
Rich – The Florida Museum of Nautural History Butterfly Rainforest
Vincent – JoVE, the Journal of Visualized Experiments

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TWiV 93: Our infectious inbox

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich answer listener questions about lab procedures, prokaryotes, endogenous retroviruses, the iPad and teaching, prions, mimivirus, splitting water with viruses, and the polio outbreak in Tajikistan.

Click the arrow above to play, or right-click to download TWiV #93 (76 MB .mp3, 105 minutes)

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Links for this episode:

Weekly Science Picks

Alan – Southern Fried Science
Rich – Tree of Life web project
Vincent – Dickson Despommier at Big Think

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TWiV 92: Live at ASV in Bozeman

Hosts: Vincent Racaniello, Rich Condit, Karla Kirkegaard, and Marilyn Roosinck

Vincent, Rich, Karla, and Marilyn recorded TWiV at the 29th Annual Meeting of the American Society for Virology in Bozeman, where they discussed plant viruses and how they make plants resistant to adverse conditions, and identification of dominant negative drug targets.

Click the arrow above to play, or right-click to download TWiV #92 (42 MB .mp3, 57 minutes)

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Weekly Science Picks

Marilyn – Viruses in the faecal microbiota of monozygotic twins and their mothers (Nature)
Rich – The Known Universe by the American Museum of Natural History
Vincent – The Red Queen by Matt Ridley (thanks, Jesper!)

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TWiV 91: You’re an ERVous wreck

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Welkin Johnson

Vincent, Dickson, Alan, Rich and Welkin discuss the nature, origin, and evolution of endogenous retroviruses (ERVs), and the recent finding of endogenous filovirus genomes in mammals.

Click the arrow above to play, or right-click to download TWiV #91 (64 MB .mp3, 89 minutes)

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Weekly Science Picks

Welkin – Advice for a Young Investigator by Santiago Ramon y Cajal
Rich – How microbes define and defend us
Dickson – H1N1 virus lacks 1918 virus killer protein
Alan – The Xtal Set Society
Vincent – Antibodies and the quest for an AIDS vaccine

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TWiV 90: Guano happens

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Eric F. Donaldson

Vincent, Alan, Rich and Eric discuss identification of viruses in Northeastern American bats, vaccinia virus infection after sexual contact with a military vaccinee, and identification of a new flavivirus from an Old World bat in Bangladesh.

Click the arrow above to play, or right-click to download TWiV #90 (64 MB .mp3, 89 minutes)

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Links for this episode:

Weekly Science Picks

Eric – Year of Darwin by Sean Carroll
Rich – March of the Penguins
Alan – Standing-height desks
Vincent – DengueWatch (thanks Richard!)

Send your virology questions and comments to twiv@microbe.tv.

The Hosts of TWiV

Vincent Racaniello, Ph.D.


Brianne Barker, Ph.D.


Rich Condit, Ph.D.


Dickson D.
Despommier, Ph.D.


Alan Dove, Ph.D.


Daniel Griffin, M.D.,
Ph.D., CTropMed CTH


Angela Mingarelli, DVM


Jolene Ramsey, Ph.D.


Kathy Spindler, Ph.D.


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