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Tag: leishmaniasis

  • Episodes

TWiP 187: Granny’s granuloma

  • August 29, 2020
  • Tagged as: Chagas disease, granuloma, heme oxygenase, leishmaniasis, malaria, parasite, parasitism, parasitology, Toxocara

Dickson, Daniel and Vincent solve the case of the Middle Aged Woman with Loss of Vision in One Eye, and discuss the role of heme oxygenase in the various protozoan infections.

1 Reply
  • Episodes

TWiP 175: None alone pathognomonic

  • September 4, 2019
  • Tagged as: erythrocyte invasion, Kala Azar, Leishmania donovani, leishmaniasis, malaria, malaria vaccine, neutralizing antibodies, non-neutralizing antibodies, parasite, parasitism, parasitology, PfRH5, sandfly, Sudan

The TWiP’ers solve the case of the Sudanese Boy With Fever, and reveal antibodies that slow invasion of red blood cells potentiate other malaria-blocking antibodies

1 Reply
  • Episodes

TWiP 164: Surf n’ perf

  • January 12, 2019
  • Tagged as: endosymbiont, leishmaniasis, parasite, parasitism, parasitology, Sodalis glossinidius, symbiosis, Trypanosoma brucei, tsetse fly, Wigglesworthia, Wigglesworthia glossinidia

The TWiP legends solve the case of Surfer Sans Septum, and discuss how two symbiotic bacteria in the tsetse fly might allow colonization with Trypanosoma brucei.

2 Replies
  • Episodes

TWiP 153: Ars longa, vita brevis

  • June 12, 2018
  • Tagged as: caspase, dysentery, Entamoeba histolytica, IL-1beta, inflammasome, Leishmania donovani, leishmaniasis, microbiome, neutrophil, parasite, parasitism, sand fly

Vincent and Daniel solve the case of the Panamanian Farmer with Three Weeks of Diarrhea, and discuss how microbes egested during bites of sand flies exacerbate the severity of leishmaniasis.

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  • Episodes

TWiP 126: A virus walks into a parasite

  • February 4, 2017
  • Tagged as: dsRNA virus, leishmania, leishmaniasis, leishmaniavirus, parasite, parasitism, T cells, vaccine
TWiP

The TWiP Trinity solve the case of the Peace Corps volunteer with diarrhea, and reveal how immunizing against a virus ameliorates exacerbated leishmaniasis.

1 Reply
  • Episodes

TWiP 117: Parasitic puzzles

  • September 26, 2016
  • Tagged as: cutaneous leishmaniasis, dsRNA, IL-17A, interferon gamma, Leishmania mexicana, leishmaniasis, leishmaniavirus, metastatic leishmaniasis, parasite, parasitism
TWiP

The parasite prophets solve the case of the Thai Man with Abdominal Distention, and discuss the finding that metastatic leishmaniasis dependent on a virus can be prevented by blocking IL-17A.

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  • Episodes

TWiP 108: B1 cells and Leishmania, insider traitors

  • April 23, 2016
  • Tagged as: B-1 cells, hepatosplenomegaly, Kala Azar, leishmania, leishmaniasis, parasite, parasitism, phagocytosis, promastigote
TWiP

The case of the Man from Assam is solved, and phagocytosis of Leishmania by B-1 cells is brought to you by the Three Twipeteers on this episode of TWiP.

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  • Episodes

TWiP 96: Salivary pharmacopeia

  • October 3, 2015
  • Tagged as: Ankylostoma braziliense, Belize, cutaneous, cutaneous larva migrans, foxp3, IL10, immune response, leishmania, leishmaniasis, parasite, parasitism, saliva, sandfly, Th1, Th2, Treg, vector

The TWiPanosomes solve the case about the Young Woman who Went to Belize, and relate how sandfly saliva skews the immune response and increases risk of cutaneous leishmaniasis.

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  • Episodes

TWiP 53: Anti-saliva immunity

  • April 20, 2013
  • Tagged as: Dickson Despommier, leishmania, leishmaniasis, Lutzomyia longipalpis, parasite, parasitism, saliva, sandfly, twip
Lutzomyia longipalpis sandfly

Vincent and Dickson discuss the finding that immunity to a sandfly salivary protein protects against fatal visceral leishmaniasis in hamsters.

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