Marion Avril of MalarVx, Inc. joins TWiP to discuss an accelerated prime-and-trap regimen using repRNA-based circumsporozoite vaccine.
TWiP 234: Hookworms and a leech – parasites suck!
- May 4, 2024
- Tagged as: clinical trial, hookworm, Necator, paediatric, parasite, parasitism, parasitology, vaccine
TWiP discusses hookworm infection and the phase 1 clinical trial for a hookworm vaccine that could one day protect children from the hookworm anaemia, and reduce transmission of this infection.
TWiP 228: Parasitic fountain of youth
- February 6, 2024
- Tagged as: ant worker, malaria, monoclonal antibody, parasite, parasitism, parasitology, tapeworm, vaccine
TWiP discusses a tapeworm that causes extreme lifespan extension in infected ant workers, and a candidate antibody drug for prevention of malaria.
TWiP 223: Voluminous diarrhea
- November 28, 2023
- Tagged as: diarrhea, malaria, parasite, parasitism, parasitology, vaccine
TWiP solves the case of the Haitian female with AIDS and voluminous diarrhea, and review the pathogenesis, epidemiology, prevention and treatment of malaria Chagas disease.
TWiP 220: Denies any bug bites
- August 20, 2023
- Tagged as: babesia, malaria, mRNA vaccine, parasite, parasitism, parasitology, T cell, tick, vaccine
TWiP solves the case of the Hiker from Queens who Denies Bug Bites, and reveal two different malaria experimental vaccines that target different parts of the parasite life cycle.
TWiP 208: A red herring
- August 18, 2022
- Tagged as: anisakis, malaria, parasite, parasitism, parasitology, sushi, vaccine
The TWiP team solves the case of the Woman Who Vomited Up a Worm, and discuss how malaria transmission intensity can modify the effectiveness of the RTS, S/AS01 vaccine in Africa.
TWiP solves the case of the Adventurous Eater with Areas of Swelling, and discusses an experimental Trypanosoma vivax vaccine comprising an invariant flagellum antigen.
TWiP 126: A virus walks into a parasite
- February 4, 2017
- Tagged as: dsRNA virus, leishmania, leishmaniasis, leishmaniavirus, parasite, parasitism, T cells, vaccine
The TWiP Trinity solve the case of the Peace Corps volunteer with diarrhea, and reveal how immunizing against a virus ameliorates exacerbated leishmaniasis.
TWiP 125: Third time’s a charm
- January 21, 2017
- Tagged as: Anopheles, malaria, mosquito, parasite, parasitism, parasitology, Plasmodium falciparum, sporozoite, vaccine
The TWiPonderers solve the case of the Timber Worker with Severe Shaking Chills, and describe an experimental malaria vaccine comprising attenuated sporozoites produced by genetic engineering.
The TWiP ternion solve the case of the Man from Mexico, and discuss a transgenic toxoplasma vaccine for chickens using Eimeria tenella.