TWiV explains that a recent report suggesting that the SARS-CoV-2 spike protein inhibits V(D)J recombination in vitro would not impact immunity after infection or vaccination, and describes the isolation of remdesivir resistant mutants in cells in culture, and the emergence of amino acid changes in the spike protein identical to those in variants of concern, in the absence of immune selection.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler
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Links for this episode
- Spike protein inhibition of V(D)J recombination in vitro (Viruses) 6:30
- Evolutionary predictability of SARS-CoV-2 (PLoS Path) 40:34
- Letters read on TWiV 830 1:12:23, 2:04:45
- Timestamps by Jolene. Thanks!
Weekly Picks 1:44:00
Kathy – When do we get back to normal? Maybe now.
Rich – The Covid-19 Pandemic
Alan – Yaupon Brothers American tea
Vincent – Cracking the genetic code (and Niremberg’s account)
Justin – Partisan vaccination
Lisa – The Red Flag
Intro music is by Ronald Jenkees
Send your virology questions and comments to firstname.lastname@example.org
Did Alan mean Persian rather than Arabic? I’ve not been able to find the site he referred to about Covax 19. He says it is being distributed in Iran, so I would expect a web site to publish in Persian (aka Farsi)
The Coronavirus was fiddling while New York burned.