TWiV 742: De-fusing COVID-19

April 11, 2021

TWiV reviews a drug screen for inhibitors of syncytium formation, the fusing of cells caused by SARS-CoV-2, which reveals that the process is regulated by a calcium-activated ion channel and scramblase that is inhibited by the anti-parasite drug Niclosamide.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker

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Intro music is by Ronald Jenkees

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2 comments on “TWiV 742: De-fusing COVID-19

  1. Kathy’s (12 min YouTube) Pick: The Transcontinental Burrito Hypertunnel

  2. John Hempel Apr 14, 2021

    Further positive results with niclosamide would of course be great, esp since it’s off-patent.

    From its Wikipedia page, fascinating what all else it’s good for, incl: “Researchers have found that niclosamide is effective in killing invasive zebra mussels in cool waters.”