TWiV notes the passing of Mavis Agbandje-McKenna, and reviews data on maximizing fit for cloth and medical procedure masks, SARS-CoV-2 total and subgenomic viral load in hospitalized patients, and effect of changes in spike protein on efficacy in a mouse model of infection.
Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker
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Download TWiV 728 (79 MB .mp3, 132 min)
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Links for this episode
- Mavis Agbandje-McKenna dies (UF) 1:15
- Mavis on TWiV 448 1:30
- Maximizing mask fit (MMWR) 6:37
- Genomic and subgenomic RNA in COVID-19 patients (medRxiv) 22:43
- Effect of spike changes on protection of mice (mBio) 47:11
- Letters read on TWiV 728 1:07:40
- Timestamps by Jolene. Thanks!
Weekly Picks 1:53:57
Dickson – Wild animal photos
Brianne – Greater than COVID
Alan – WHO report on infodemic response
Rich – Reference Guide to the International Space Station
Vincent – 3D Molecular Designs
Listener Picks
Lisbeth – Have the new jab
Karen – Cholera exhibit at Museum of Trades and Crafts
Intro music is by Ronald Jenkees
Send your virology questions and comments to twiv@microbe.tv
Thank you again for the great podcast. Just a note: it looks like link in the notes titled “Effect of spike changes on protection of mice (mBio)” is linked to the wrong paper.
Thank you again for all you folks do.
As I recall Jason said in TWiV714 that in although the RNA vaccines did leave the S1/S2 furin cleavage in place they made some addition changes close to it in addition to the prolines around S2′.