Doris Cully joins TWiV to discuss inhibition of SARS-CoV-2 in cell culture by ivermectin, followed by continuing analysis of the coronavirus pandemic caused by SARS-CoV-2 including COVID-19 in Nadia the tiger, and prediction of respiratory failure by levels of IL-6.
Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Brianne Barker
Guest: Doris Cully
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Links for this episode
- Ivermectin inhibits SARS-CoV-2 in cell culture (Antiviral Res) 2:39
- Tiger at NY zoo positive for SARS-CoV-2 (NY Times) 28:30
- IL-6 level predicts respiratory failure in COVID-19 patients (medRxiv) 36:00
- Infection fatality rate for managing pandemic (virology blog) 40:39
- Letters read on TWiV 599 32:36, 1:01:51
- Image credit
- Timestamps by Jolene. Thanks!
Intro music is by Ronald Jenkees.
Send your virology questions and comments to twiv@microbe.tv
Excellent, informative podcast. I worked with the early clinical trials with Ivermectin in 1983 and then bioengineered a human 3-D bronchial epithelial cells as investigative platform for host cell-pathology & virion production of SARs-CoV in 2003. And now early research efforts are coming forward again.
I’m glad someone finally asked about freezing !
Memes were saying 26-27 degrees C “kills” the virus. This obviously is false since human body temperature is 37 degrees C.
It would be interesting to know how viruses survive freezing. It would seem that expanding ice, freezing around glycoprotein spikes would potentially break them off.
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Is there a link to the vacuum cleaner bag filter mask study ?
Yup, I’m looking for that
Found it.
https://www.researchgate.net/publication/258525804_Testing_the_Efficacy_of_Homemade_Masks_Would_They_Protect_in_an_Influenza_Pandemic
Also see
https://twitter.com/carlwangyang/status/1251484888701829121?s=20
Hi TWiV team,
Thanks for yet another great podcast.
Cheers,
Cam
Regarding Hepa filter bags.
Quote:
“There are two common types of air purifiers that can remove some or all of the disease and allergy-causing particles in the air: mechanical filters—the most effective are classified as High Efficiency Particulate Air filters (HEPA filters)—and electrostatic precipitators.
HEPA filters are made out of very fine glass threads with a diameter of less than 1 micron (a micron is 0.00004 in, 0.001 mm).”
http://www.madehow.com/Volume-7/Air-Purifier.html
I have not yet heard anything about the warm weather coming, and with it flying insects — flies, gnats which like to fly into one’s face, and, of course, mosquitoes. What is known about transmission by contact with these?
Great Podcast Team Twiv, Thanks so much, great to hear expertise in action.
Pardon, if i may ask a question,
I was wondering if you heard the notion that COVID-19 is being treated incorrectly as a disease that leads to ARDS where it’s actually more of a virus thats desaturating oxygen in blood and that ventilation is not the best treatment. Is there any truth to that?
Thanks,
https://www.usatoday.com/story/news/nation/2020/03/21/coronavirus-quarantine-haunts-polio-epidemic-survivors/2868771001/
The last time anybody in the USA went through a pandemic was the polio pandemic and it affected president FDR at the time. Also there were ventilator shortages too at the time. This was prior to the Polio vaccine being approved.
https://abc7news.com/coronavirus-pandemic-polio-epidemic-was-a-scare/6082265/
Questions Re: antibody levels, antibody testing and reliability of tests
Is it true that one difficulty being encountered in finding reliable antibody tests for general use is the wide variation in antibody levels observed between sufferers of mild vs severe Covid19? Does this apply to detecting both IGG and IGM? Do any of your experts have suggestions or understanding of how this difficulty might be overcome for developing tests?
Also : what would such variations imply for future immunity for those who experience only mild disease symptoms? And, would this mean that convalescent plasma from people who had only mild symptoms would be less useful to hospitals using it to treat severe cases?
I would like to know in the next wave of the virus those who had it and lived . Who didnot need to be in the hospital will they have antibodies against the next wave???? And next what do u think about all the fake cures for the virus? Inhealing steam will not cure you !,only the correct anti-virus and your immune system.. what is your take on this . I find listening to you guys is so Intresting I have learned alot from listing to u guys talking I wish I could get feedback.
Thank you for the interesting discussion of ivermectin.
I was surprised at the negativism expressed and the lack of curiosity regarding possible mechanisms of action or other types of formulation, eg could ivermectin be given as an aerosol, would it have additivity with other compounds active in vitro against Coronavirus. Also, given the fact the drug is highly lipid soluble we don’t really know if the plasma levels are relevant for its action in vivo.