Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler
For a TWiV Thanksgiving, Vincent, Alan, and Kathy trace the feud over genome editing, a new virus discovered in human blood, and the origins of hepatitis A virus.
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Download TWiV 365 (79 MB .mp3, 110 min)
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Links for this episode
- Battle over genome editing (Wired) 10:05
- First description of CRISPR in E. coli (J Bacteriol) 14:00
- Cas genes identified (Mol Micro) 14:20
- CRISPR-Cas provides immunity to bacterial viruses (Science) 15:35
- Cas9-crRNA complex mediates DNA cleavage (PNAS) 16:55
- Dual RNA-guided DNA endonuclease in bacterial immunity (Science) 17:50
- Genome engineering using CRISPR/Cas (Science) 18:50
- Cpf1 endonuclease (Cell) 23:10
- Classification of CRISPR/Cas systems (Nat Rev Micro) 23:50
- Summit on gene editing 21:25
- Novel human virus in transfusion recipients (mBio) 27:00
- Origins of hepatitis A virus in small mammals (PNAS) 55:05
- Image credit
- Letters read on TWiV 365 7:00, 1:20:35
This episode is sponsored by ASM Microbe, ASM Biodefense, and the 32nd Clinical Virology Symposium. (1:10, 1:18:30)
Timestamps by Jennifer. Thanks!
Weekly Science Picks 1:36:30
Kathy – Tardigrade genome sequence (video)
Alan – XKCD on Gates polio eradication site
Vincent – Lifting the Impenetrable Veil by Charles Calisher
Listener Picks
Judi – Jennifer Doudna’s Ted Talk
Ramon – Map of the Sky
Send your virology questions and comments to twiv@microbe.tv
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