Vincent, Alan, and Marc talk about chronic wasting disease of deer caused by prions, blocking the semen-derived enhancer of HIV infection with surfen, and making green transgenic rabbits using a lentiviral vector.
Vincent and Dickson continue virology 101 with a discussion of information flow from RNA to DNA, a process known as reverse transcription, which occurs in cells infected with retroviruses, hepatitis B virus, cauliflower mosaic virus, foamy viruses, and even in uninfected cells.
Vincent, Alan, and Matt discuss a project to study the RNA virome of Northeastern American bats, failure to detect XMRV in UK chronic fatigue syndrome patients, and DNA of bornavirus, an RNA virus, in mammalian genomes.
Vincent, Alan, and Rich discuss ten compelling virology stories of 2009.
Vincent, Alan, and Rich talk about US government contract for freeze-dried smallpox vaccine, red squirrels in the UK threatened by poxvirus, and Marseillevirus, another DNA virus from amoebae built for comfort and speed.
Vincent, Dickson, and Alan discuss STEP HIV-1 vaccine failure caused by the adenovirus vector, presence of West Nile virus in kidneys for years after initial infection, adaptation of the influenza viral RNA polymerase for replication in human cells, and the significance of the D225G change in the influenza HA protein.
Vincent and Dick muse about the symbiotic bacterium, Wolbachia, that protects flies from viral infection, the origin of 2009 influenza H1N1 virus, and the lure of original antigenic sin.
Vincent and Dick continue Virology 101 with a discussion of how RNA viruses produce mRNA and replicate their genomes.
A TWiV panel of five considers the finding of Streptococcus pneumoniae in fatal H1N1 cases in Argentina, hysteria in the Ukraine over pandemic influenza, and human vaccinia infection after contact with a raccoon rabies vaccine bait.
Vincent, Dick, and Alan are joined by emergency medicine physician Dr. Joshua Stillman to talk about passive antibody therapy for Nipah infection in ferrets, annual influenza immunization of children, facemasks to prevent influenza, predicting dengue outbreaks by the weather, and the amazing viral communities in an icy Antarctic lake.