The TWiVsters reveal new giant viruses that argue against a fourth domain of life, and discovery of viruses in the oceanic basement.
TWiV 374: Discordance in B
- January 31, 2016
- Tagged as: 5'-tyrosyl DNA phosphodiesterase, activation-induced cytidine deaminase, AID, Burkitt, Burkitt's lymphoma, c-myc, cancer, coxsackievirus, Epstein-Barr virus, hypermutation, malaria, oncogene, picornavirus, Plasmodium falciparum, poliovirus, replication, rhinovirus, TDP2, translation, translocation, unlinkase, viral, virology, virus, viruses, VPg
The TWiVniks consider the role of a cell enzyme in removing a protein linked to the 5′-end of the picornavirus genome, and the connection between malaria, Epstein-Barr virus, and endemic Burkitt’s lymphoma.
The Masters of the ScienTWIVic Universe discuss a novel poxvirus isolate from an immunosuppressed patient, H1N1 and the gain-of-function debate, and attenuation of dengue virus by recoding the genome.
Vincent, Alan and Rich explain how to make a functional ribosome with tethered subunits, and review the results of a phase III VSV-vectored Ebolavirus vaccine trial in Guinea.
TWiV 346: A double helical career
- July 19, 2015
- Tagged as: bacteriophage, Francis Crick, Jim Watson, Joan Steitz, microrna, mRNA, non-coding RNA, R17, Shine-Delgarno, snRNA, snRNP, splicing, translation, viral, virology, virus
This episode was recorded at the 34th Annual Meeting of the American Society for Virology, where Vincent, Rich, and Kathy spoke with Joan Steitz, a tireless promoter of women in science and one of the greatest scientists of our generation.
Tre TWiV amici present three snippets and a side of sashimi: how herpesvirus inhibits host cell gene expression by disrupting transcription termination.
Lee joins the TWiV team to discuss the value of post-doctoral training, and how a cellular microRNA assists in the replication of hepatitis C virus.
Vincent, Rich and Kathy discuss mechanisms of protein synthesis and regulation in virus-infected cells.
Vincent, Alan, and Rich review association of an interferon-induced protein with severe influenza, and stabilization of HCV RNA by a microRNA.
During a trip to California, Vincent visited Peter Sarnow and Bert Semler and spoke with them about their work on internal ribosome entry, and the requirement for a cellular microRNA for hepatitis C virus replication.