TWiV reviews the difficulties in predicting species susceptibility to SARS-CoV-2 infection by only examining the ACE2 protein, and the olfactory mucosa as a portal of entry into the central nervous system in COVID-19 patients.
TWiV 614: COVID Tetris – Test, trace, isolate
- May 17, 2020
- Tagged as: coronavirus, COVID-19, furin, pandemic, SARS-CoV-2, spike glycoprotein, Vaccine, viral, virology, virus, viruses
Daniel Griffin provides a clinical update on COVID-19, then we review results showing requirement for the furin site in the SARS-CoV-2 spike for replication, US state vaccine exemptions, concerns with a rapid diagnostic test, and answers to listener questions.
TWiV 588: Coronavirus update – Save the pangolin!
- February 23, 2020
- Tagged as: ACE2, China, coronavirus, CoV, COVID-19, epidemic, evolution, furin, pangolin, pneumonia, receptor binding domain, respiratory aerosol, SARS-CoV-2, spike glycoprotein, viral, virology, virus, viruses, Wuhan, zoonosis
The TWiV team returns this week to SARS-CoV-2019 coverage to review the latest epi curves, the fatality rate, furin cleavage site and receptor binding domain in the spike glycoprotein, related CoV recovered from pangolins, evidence that the virus did not escape from a laboratory, and many more questions sent in by listeners.
TWiV 364: It’s not SARS 2.0
- November 22, 2015
- Tagged as: bat, coronavirus, gain of function, host range, infectious viral DNA, MERS, pathogenesis, SARS, spike glycoprotein, tropism, viral, virology, virus, viruses, zoonoses, zoonosis
Vincent, Rich, and Kathy speak with Ralph and Vineet about their research on the potential of SARS-like bat coronaviruses to infect human cells and cause disease in mice.