The TWiV hosts discuss the distribution of prions in the eyes of patients with sporadic Creutzfeldt-Jacob disease, and the origins and evolution of RNA viruses.

The TWiVerinoes discuss the potential for prion spread by plants, global circulation patterns of influenza virus, and the roles of Argonautes and a viral protein in RNA silencing in plants.

Vincent visits the Rocky Mountain Laboratories in Hamilton, Montana and speaks with Marshall, Sonja, and Byron about their work on tick-born flaviviruses, innate immunity, and prion diseases.

Vincent, Dickson, Alan, and Rich answer listener questions about maternal infection and fetal injury, viral gene therapy, eyeglasses and influenza, filtering prions from blood, eradication of rinderpest, Tamiflu resistance of H1N1 influenza, bacteriophages and the human microbiome, H1N1 vaccine recalls, human tumor viruses, RNA interference, and junk DNA.