gene therapy | This Week in Virology

The TWiV team reviews the first FDA approved gene therapy, accidental exposure to poliovirus type 2 in a manufacturing plant, and production of a candidate poliovirus vaccine in plants.

In the second of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on RNA viruses, and what they would be doing if they were not scientists.

Netcast

TWiV 350: Viral gene therapy with Katherine High

August 16, 2015
Tagged as: aav, adeno-associated virus, blindness, factor IX, gene therapy, hemophilia, Katherine High, Leber's congenital amaurosis, monogenetic, vector, viral, virology, virus

Vincent speaks with Katherine High about her career and her work on using viral gene therapy to treat inherited disorders.

Netcast

TWiV 326: Giving HIV a flat tyr

March 1, 2015
Tagged as: aav, adeno-associated virus, CD4, eCD4-Ig, gene therapy, hiv, human immunodeficiency virus, immunoadhesin, immunoglobulin, sCD4-Ig, SHIV, simian immunodeficiency virus, siv, viral, virology, virus

The sternutating TWiVers discuss preventing infection of cells and animals by a soluble CD4-CCR5 molecule that binds to HIV-1 virus particles.

Netcast

TWiV 214: This is your brain on polyomavirus

January 6, 2013
Tagged as: adenovirus, chemokine, coagulation factor, cytokine, factor X, gene therapy, innate immunity, malignant peripheral nerve sheath tumor, polyomavirus, sarcoma, TLR4, tumor, viral, virology, virus

Vincent, Alan, and Kathy discuss how coagulation factor X binding to adenovirus activates the innate immune system, and a novel polyomavirus associated with brain tumors in raccoons.

Netcast

TWiV 102: Catch me if you can in Munich

October 10, 2010
Tagged as: adenovirus, cardiovascular disease, Flu, gene therapy, influenza virus, innate immunity, mononegavirales, rabies, rig-i, sfb455, Vaccine, viral, virology, virus

A conversation about the RNA sensor RIG-I, adenovirus gene therapy, a universal influenza vaccine, and rabies virus, recorded in Munich, Germany at the SFB455 symposium ‘Viral offense and immune defense’.

Netcast

TWiV 88: A bug fix, an AIDS treatment, and an undead retrovirus

June 27, 2010
Tagged as: AIDS, baculovirus, endogenous retrovirus, gene therapy, hiv, nudivirus, retrovirus, rhinoceros beetle, viral, virology, virus

Vincent, Alan, and Marc discuss using a virus for beetle control, RNA based gene therapy for AIDS, and reconstitution of a endogenous human retrovirus.

Netcast

TWiV 71: Please Mr. Postman

February 28, 2010
Tagged as: bacteriophage, gene therapy, H1N1, influenza, junk dna, microbiome, pregnancy, prion, retrovirus, rinderpest, RNA interference, tamiflu, tumor virus, TWiV, Vaccine, viral, virology, virus

Vincent, Dickson, Alan, and Rich answer listener questions about maternal infection and fetal injury, viral gene therapy, eyeglasses and influenza, filtering prions from blood, eradication of rinderpest, Tamiflu resistance of H1N1 influenza, bacteriophages and the human microbiome, H1N1 vaccine recalls, human tumor viruses, RNA interference, and junk DNA.

Netcast

TWiV 22: Viral bioinformatics

February 28, 2009
Tagged as: AIDS, gene therapy, HBV, hepatitis, hiv-1, influenza, myxoma, poxvirus, Vaccine, vaccinia

Vincent and Chris Upton converse about hepatitis B in India, AIDS gene therapy with a ribozyme, antibodies that neutralize many influenza virus strains, killing tumors with vaccinia virus, myxoma virus of rabbits, and the Viral Bioinformatics Resource Center.

Tag: gene therapy

TWiV 459: Polio turns over a new leaf

TWiV 407: Tar Heels go viral, part two

TWiV 350: Viral gene therapy with Katherine High

TWiV 326: Giving HIV a flat tyr

TWiV 214: This is your brain on polyomavirus

TWiV 102: Catch me if you can in Munich

TWiV 88: A bug fix, an AIDS treatment, and an undead retrovirus

TWiV 71: Please Mr. Postman

TWiV 22: Viral bioinformatics

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