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Tag: gain of function

  • Netcast

TWiV 303: Borna this way

  • September 21, 2014
  • Tagged as: aerosol, airborne, Borna disease virus, Ebola, ebolavirus, endogenous viral DNA, gain of function, negative strand, pandemic, replication, thirteen lined ground squirrel, transmission, viral, virology, virus

The TWiV team discusses transmission of Ebola virus, and inhibition of Borna disease virus replication by viral DNA in the ground squirrel genome.

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  • Netcast

TWiV 295: A nonslip grippe and Lassa’s LAMP

  • July 27, 2014
  • Tagged as: a-dystroglycan, arenavirus, cell entry, ferret, fusion, gain of function, haploid genetic screen, hemorrhagic fever, influenza, LAMP, Lassa virus, miRNA, receptor, viral, virology, virus

The TWiVome discusses an miRNA based strategy to mitigate risk of gain of function studies, and identification of a second receptor required for Lassa virus entry.

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  • Netcast

TWiV 287: A potentially pandemic podcast

  • June 1, 2014
  • Tagged as: aerosol transmission, avian influenza H5N1, coronavirus, ferret, fouchier, gain of function, kawaoka, laboratory accident, MERS-CoV, Middle East respiratory syndrome, Nuremberg, pandemic, SARS, viral, virology, virus

Matt updates the TWiV team on MERS-coronavirus, and joins in a discussion of whether we should further regulate research on potentially pandemic pathogens.

3 Replies
  • Netcast

TWiV 246: Pandora, pandemics, and privacy

  • August 18, 2013
  • Tagged as: avian influenza H7N9, fouchier, gain of function, genome, hela, Henrietta Lacks, kawaoka, mimivirus, Pandoravirus, sequence, viral, virology, virus

Vincent, Alan, Rich, and Kathy discuss the huge Pandoravirus, virologists planning H7N9 gain of function experiments, and limited access to the HeLa cell genome sequence.

2 Replies
  • Netcast

TWiV 233: We’re surrounded

  • May 19, 2013
  • Tagged as: aerosol transmission, avian influenza, CoV-MERS, gain of function, guinea pig, H1N1, H5N1, H7N9, MERS coronavirus, Middle East coronavirus, reassortants, respiratory infection, TWiV, viral, virology, virulence, virus

Vincent, Rich, Alan and Kathy review aerosol transmission studies of influenza H1N1 x H5N1 reassortants, H7N9 infections in China, and the MERS coronavirus.

5 Replies
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