Tag: cGAMP

The TWiVumvirate discuss the giant Tupanvirus, with the longest tail in the known virosphere, and dampened STING dependent interferon activation in bats.

Brianne joins the TWiVMasters to explain how mutations in genes encoding RNA polymerase III predispose children to severe varicella, and detection of an RNA virus by a DNA sensor.

The TWiVniacs discuss twenty-eight years of poliovirus shedding by an immunodeficient patient, and packaging of the innate cytoplasmic signaling molecule cyclic GMP-AMP in virus particles.

Netcast

TWiV 222: Jumpin’ Jack Flash, it’s a GAS GAS GAS

March 3, 2013
Tagged as: cGAMP, cGAMP synthase, cyclic GAMP, DNA sensor, innate immune response, second messenger, viral, virology, virus

The complete TWiV team discusses the amazing finding that cyclic GMP-AMP synthase is a cytosolic innate immune DNA sensor.

Tag: cGAMP

TWiV 484: Float like a mimivirus STING like a bat

TWiV 456: Be careful of canons

TWiV 353: STING and the antiviral police

TWiV 222: Jumpin’ Jack Flash, it’s a GAS GAS GAS

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Inside a BSL-4 laboratory