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Tag: cGAMP

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TWiV 484: Float like a mimivirus STING like a bat

  • March 11, 2018
  • Tagged as: aaRS, bat, cGAMP, cGAS, DNA sensor, IFN, interferon, irf3, mimivirus, phosphorylation, positive selection, ribosome, STING, tailed capsid, Tupanvirus, viral, virology, virus, viruses

The TWiVumvirate discuss the giant Tupanvirus, with the longest tail in the known virosphere, and dampened STING dependent interferon activation in bats.

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  • Episodes
  • Netcast

TWiV 456: Be careful of canons

  • August 26, 2017
  • Tagged as: 5'-triphosphate, cGAMP, cGAS, dengue virus, DNA sensor, inborn error, innate immunity, mitochondria, RNA polymerase III, STING, varicella, varicella-zoster virus, viral, virology, virus, viruses, VZV
TWiV

Brianne joins the TWiVMasters to explain how mutations in genes encoding RNA polymerase III predispose children to severe varicella, and detection of an RNA virus by a DNA sensor.

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  • Netcast

TWiV 353: STING and the antiviral police

  • September 6, 2015
  • Tagged as: agammaglobulinemia, cGAMP, cGAS, IFN, innate immunity, interferon, packaging, poliovirus, Sabin vaccine, shedding, STING, vaccine derived poliovirus, VDPV, viral, virology, virus, virus particle

The TWiVniacs discuss twenty-eight years of poliovirus shedding by an immunodeficient patient, and packaging of the innate cytoplasmic signaling molecule cyclic GMP-AMP in virus particles.

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  • Netcast

TWiV 222: Jumpin’ Jack Flash, it’s a GAS GAS GAS

  • March 3, 2013
  • Tagged as: cGAMP, cGAMP synthase, cyclic GAMP, DNA sensor, innate immune response, second messenger, viral, virology, virus

The complete TWiV team discusses the amazing finding that cyclic GMP-AMP synthase is a cytosolic innate immune DNA sensor.

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