TWiV 222: Jumpin’ Jack Flash, it’s a GAS GAS GAS

March 3, 2013

cyclic GAMPHosts: Vincent Racaniello, Rich ConditDickson Despommier, Alan Dove, and Kathy Spindler

The complete TWiV team discusses the amazing finding that cyclic GMP-AMP synthase is a cytosolic innate immune DNA sensor.

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2 comments on “TWiV 222: Jumpin’ Jack Flash, it’s a GAS GAS GAS

  1. Dorian McILROY Mar 23, 2013

    Thanks for a great discussion of two fantastic papers. I want to comment on a couple of points.

    Firstly, in response to a listener question about whether there are viruses that infect mitochondria or chloroplasts, maybe this doesn’t count, but there is a family of plant viroids (infectious agents that have a small circular RNA genome, but no protein) that replicate in the chloroplasts. They are the Avsunviroidae (

    Secondly, here is a link to a Ben Goldacre TED talk where he explains why the All Trials campaign is necessary.