antigenic variation | This Week in Virology

TWiV 893: Yellow fever virus escapes antibodies

April 24, 2022
Tagged as: antigenic variation, monoclonal antibody, Vaccine, viral, virology, virus, viruses, yellow fever virus, YF-17D

Kartik, Denise, and Gorka join TWiV to discuss their finding that changes in the surface glycoprotein of South American yellow fever virus lead to reduced neutralization by antibodies induced by the vaccine, which is derived from an African isolate.

TWiV 768: Can nanobody stop these variants?

June 13, 2021
Tagged as: antigenic variation, camelid, coronavirus, COVID-19, nanobody, nanomice, pandemic, SARS-CoV-2, variant of concern, viral, virology, virus, viruses

TWiV describes how human behavior, not increased transmissibility, led to increased spread of a SARS-CoV-2 variant throughout Europe in summer 2020, and nanobodies from camelid mice and llamas that efficiently neutralize variants of concern.

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TWiV 759: Pork dogs and an evolutionary pickle

May 23, 2021
Tagged as: antigenic variation, B cell epitope, canine coronavirus, COVID-19, measles virus, pandemic, porcine coronavirus, SARS-CoV-2, spillover, viral, virology, virus, viruses, zoonosis

TWiV examines spillovers of porcine and canine coronaviruses into humans in Haiti and Malaysia, and how antigenic evolution of measles virus is constrained by multiple co-dominant epitopes on the viral glycoproteins.

The TWiV teams reviews a MERS-coronavirus serosurvey and an outbreak in South Korea, and constraints on measles virus antigenic variation.

Tag: antigenic variation

TWiV 893: Yellow fever virus escapes antibodies

TWiV 768: Can nanobody stop these variants?

TWiV 759: Pork dogs and an evolutionary pickle

TWiV 340: No shift, measles

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Inside a BSL-4 laboratory