This Week in Virology

TWiV 412: WO, open the borders and rig the infection

October 23, 2016

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVome reveal the first eukaryotic genes found in a bacteriophage of Wolbachia, and how DNA tumor virus oncogenes antagonize sensing of cytoplasmic DNA by the cell.

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Zika virus in vaginal secretions (EID) 20:20
Zika virus in semen (EID) 23:45
Eukaryotic genes in a bacteriophage (Nat Commun) 29:35
Seth Bordenstein on TWiV 332 29:55
DNA tumor virus oncogenes antagonize cGAS-STING (Science) 47:15
Image credit
Letters read on TWiV 412 1:19:10

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world’s best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completely free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 26:30

This episode is also brought to you by Drobo, a family of safe, expandable, yet simple to use storage arrays. Drobos are designed to protect your important data forever. Visit www.drobo.com to learn more. Listeners can save $100 on a Drobo system at drobostore.com by using the discount code Microbe100. 0:50, 1:10:40

Weekly Science Picks 1:47:35

Mark – EFN Enterprise Futures Network and Mission Log Podcast
Alan – 2016 Wildlife Comedy Photography
Rich – ZuTA, portable robotic printer
Kathy – How LEGO help blind people see
Vincent – Airplane photos of Mike Kelley

Listener Pick

Hannah – Frozen Flow Glass (Instagram)

Send your virology questions and comments to twiv@microbe.tv

TWiV 411: Chicken runs

October 16, 2016

Drawing by Strummer

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

The TWiVeroos examine a reverse spillover of Newcastle disease virus vaccines into wild birds, and identification of a protein cell receptor for murine noroviruses.

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Links for this episode

MicrobeTV Store 31:50
Florida DOH Daily Zika Update 32:40
Zika virus in new Miami neighborhood (CNN, NYTimes) 33:00
NDV vaccine virus in wild birds (PLoS One) 35:40
Protein cell receptor for murine norovirus (Science, PNAS) 49:25
Poliovirus receptor analysis (J Virol) 1:00:50
Letters read on TWiV 411 6:10, 1:11:10

Weekly Science Picks 1:22:50

Alan – Braincraft
Rich – Now is the Greatest Time to Be Alive
Kathy – CRISPR/Cas9 by A Capella Science
Vincent – Microbes After Hours: The Necromicrobiome

Listener Pick

Jolene – Chalk Talk Science by Dennis Mangan

Send your virology questions and comments to twiv@microbe.tv

TWiV 410: Hurricane Zika

October 9, 2016

Sharon Isern and Scott Michael. Photo by Melissa Neubek.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Guests: Sharon Isern and Scott Michael

Sharon and Scott join the TWiV team to talk about their work on dengue antibody-dependent enhancement of Zika virus infection, and identifying the virus in mosquitoes from Miami.

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Links for this episode

Live at Florida Gulf Coast University (TWiV #111) 4:20
Florida DOH Daily Zika Update 7:45
Regional Zika update, Americas (PAHO, WHO) 11:45
NJ Zika Bill 14:55
Dengue virus antibodies enhance Zika virus infection (bioRxiv)33:30
First detection of Zika virus in Brazilian A. aegyptii (Mem Inst Oswaldo Cruz) 1:07:00
2017 ASM Scientific Writing and Publishing Online Course 1:57:40
Letters read on TWiV 410 1:11:00

Zika virus in Florida. Source: Florida Weekly Arbovirus Reports.

Weekly Science Picks 1:44:30

Sharon – Zika virus comics and cartoons and Florida weekly arbovirus reports
Scott – Real-time tracking of Zika virus evolution
Alan – Evolution of antibiotic resistance on a mega plate
Rich – Windytv
Kathy – Zika virus map and timeline
Vincent – Ohsumi Nobel advanced information and HR 5325 funding breakdown

Send your virology questions and comments to twiv@microbe.tv

TWiV 409: A Nef is enough

October 2, 2016

This image has nothing to do with Nef, but is all about a grateful listener, Erik.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Guest: Jeremy Luban

Jeremy joins the TWiVeroids to tell the amazing story of how the function of the HIV-1 protein called Nef was discovered and found to promote infection by excluding the host protein SERINC from virus particles.

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Weekly Science Picks 1:44:30

Alan – Migration in Motion
Dickson – Beautiful Chemistry
Rich – XKCD Timeline of Earth Temperature
Kathy – Vaccine Heroes from Vaccine Education Center
Jeremy – CIDRAP posters and Demon in the Freezer
Vincent – People Peas and Pathogens

Listener Picks

Matlock – Science isn’t broken

Send your virology questions and comments to twiv@microbe.tv

TWiV 408: Boston Quammens

September 25, 2016

Hosts: Vincent Racaniello and Alan Dove

Guest: David Quammen

Four years after filming ‘Threading the NEIDL’, Vincent and Alan return to the National Emerging Infectious Diseases Laboratory BSL4 facility at Boston University where they speak with science writer David Quammen.

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Download TWiV 408 (42 MB .mp3, 69 min)
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Links for this episode

David Quammen’s website
Spillover by David Quammen
Threading the NEIDL (TWiV 200)
The NEIDL at Boston University

Send your virology questions and comments to twiv@microbe.tv

TWiV 407: Tar Heels go viral, part two

September 21, 2016

Host: Vincent Racaniello

Guests: Ralph Baric, Kristina De Paris, Tal Kafri, Helen Lazear, Mark Heise, and David Margolis

In the second of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on RNA viruses, and what they would be doing if they were not scientists.

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Send your virology questions and comments to twiv@microbe.tv

TWiV 407: Tar Heels go viral, part one

September 18, 2016

Host: Vincent Racaniello

Guests: Dirk Dittmer, Cary Moody, Nat Moorman, Nancy Raab-Traub, Lishan Su, and Jennifer Webster-Cyriaque

In the first of two shows recorded at the University of North Carolina in Chapel Hill, Vincent meets up with faculty members to talk about how they got into science, their research on DNA viruses, and what they would be doing if they were not scientists.

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Download TWiV 407a (43 MB .mp3, 71 min)
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Send your virology questions and comments to twiv@microbe.tv

TWiV 406: Pow, right in the enteroids!

September 11, 2016

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The TWiV team discusses eye infections caused by Zika virus, failure of Culex mosquitoes to transmit the virus, and replication of norovirus in stem cell derived enteroids.

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Download TWiV 406 (59 MB .mp3, 98 min)
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Links for this episode

Florida DOH daily Zika update 12:15
Congress fails again on Zika (NY Times) 13:25
Culex pipiens does not support Zika virus replication (EID) 17:00
Zika virus in the eye (Cell Rep) 20:00
Norovirus replication in enteroids (Science) 31:45
Norovirus replication in B cells (TWiV 312) 36:35
Baylor press release 39:00
Norovirus replication in B cells confirmed (Antiviral Res) 39:45
Letters read on TWiV 406 5:05, 1:07:30

Weekly Science Picks 1:24:05

Alan – Infective Perspective
Dickson – The Living River
Rich – Freddy Mercury around the Sun
Kathy – A Day in Pompeii
Vincent – Spraying Pesticides

Listener Picks

Ricardo – Why the metric system matters
Eric – The Giving Plague by David Brin

Send your virology questions and comments to twiv@microbe.tv

TWiV 405: All the world’s a phage

September 4, 2016

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

The TWiXers discuss a study on vertical transmission of Zika virus by Aedes mosquitoes, and uncovering Earth’s virome by mining existing metagenomic sequence data.

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Links for this episode

Roger Tsien, 64 (UC San Diego Health) 16:15
CDC running out of Zika money (NYTimes) 22:40
Zika virus in Miami mosquitoes (NYTimes) 17:30
No Zika virus in Rio Olympics (NYTimes) 25:40
Vertical transmission of Zika virus in Aedes aegypti (AJTMH) 27:00
Uncovering Earth’s virome (Nature) 29:30
Image credit (Global water volume)
Letters read on TWiV 405 4:15, 1:06:40

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world’s best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 26:55

Weekly Science Picks 1:42:40

Alan – The Vizzies
Dickson – NASA Spinoff
Kathy – Maps.me
Vincent – Zika: The Emerging Epidemic by Donald McNeil

Listener Picks

Tarwin – Darwin’s Radio by Greg Bear (paper or Kindle)
Bodham – The start of scientific publishing, 1665

Send your virology questions and comments to twiv@microbe.tv

TWiV 404: Not found

August 28, 2016

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Rich Condit

From the twiVivants, follow up on FluMist and Zoster vaccines, Zika virus update, and isolation of a multicomponent animal virus from mosquitoes.

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Download TWiV 404 (91 MB .mp3, 126 min)
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Links for this episode

FluMist problem (FDA) 10:50
DA Henderson obituary (NY Times) 27:00
DA Henderson, smallpox eradicator (TWiV Special) 27:15
Efficacy of VZV vaccine(Ther Adv Vaccines) 45:00
Zika virus burden, Puerto Rico (JAMA) 49:15
Zika virus in Miami Beach(STAT) 49:05
Congenital brain anomaliesand Zika virus (Radiology) 50:30
Congenital Zika syndrome with arthrogryposis (BMJ) 56:15
Multicomponent animal virus from mosquitoes (Cell Host Microbe) 1:01:35
Breaking rules of infection (NPR) 1:01:10
Image credit
Letters read on TWiV 404 18:55, 1:27:45

This episode is brought to you by CuriosityStream, a subscription streaming service that offers over 1,400 documentaries and nonfiction series from the world’s best filmmakers. Get unlimited access starting at just $2.99 a month, and for our audience, the first two months are completel free if you sign up at curiositystream.com/microbe and use the promo code MICROBE. 0:25, 58:55