Paul and Theodora return to TWiV to explain their research on determining the number of neutralizing epitopes on the SARS-CoV-2 spike that are recognized by antibodies, and engineering of a polymutant spike with twenty amino acid changes that demonstrates the high genetic barrier to escape from convalescent serum.
Pere writes: Hello Daniel & Vincent, Thank you for your updates! I’ve been an avid listener since June 2020 (found about you late!) and as many people have said, you’re a lighthouse in these mad…
TWiV summarizes cases of arbovirus disease during 2019 in the US, and explains a study that estimates infectiousness throughout the SARS-CoV-2 course of infection.
Kimberly writes: Dear Dr. Griffin, I am a medical technologist working in biotechnology. I listen to TWiV regularly to keep current on the SARS-CoV-2 situation nationally and worldwide, and I appreciate your regular clinical updates…
Anne writes: Hello “my” virologists, I have been unable to find a CDC recommendation about singing again. My chorus Director is suggesting we gather and sing outside. I live in western Massachusetts where we have…
Jason writes: Hello Vincent, Brianne, Rich, Dickson, Kathy, Alan, Daniel, and crew! xkcd is has long been one of my favorite comics and he continues to nail it with these. I thought you’d appreciate them:…
TWiV reviews SARS-CoV-2 infection of wild white-tailed deer in the US, mRNA vaccine-mediated protection by spike-specific T cells before detection of neutralizing antibodies, and recovery from SARS-CoV-2 infection in T-cell depleted rhesus macaques.
Jason writes: Hi. We are scheduled to host a catered party in a few weeks on Long Island. Out of 130 or so guests we have a handful who are unvaccinated. I’m assuming we need…
TWiV reviews a leaked CDC document on virulence and spread of the delta variant, and how anti-alphavirus antibodies that do not neutralize infection can nevertheless protect mice from disease.
Bistra writes: Dear TWIV team, I live in the US but I am writing to you from my beautiful hometown Varna in Bulgaria where my kids and I are spending time with my parents while…
The Hosts of TWiV
Vincent Racaniello, Ph.D.
Rich Condit, Ph.D.
Dickson D.
Despommier, Ph.D.
Alan Dove, Ph.D.
Daniel Griffin, M.D.,
Ph.D., CTropMed CTH
Angela Mingarelli, DVM
Jolene Ramsey, Ph.D.
Kathy Spindler, Ph.D.