The TWiP professors solve the case of the Ugandan Child with Splenomegaly, and reveal that mutations in the P. falciparum genome that confer artemisinin resistance interfere with endocytic uptake of hemoglobin.
The podcastellani hosts solve the case of the Sailor With Dysentery, and reveal the first virus discovered in Plasmodium species.
The TWiP Wataalamu solve the case of the One Year Old From Kenya With Moving Skin Lesions, and describe how to make mosquitoes refractory to Plasmodium with engineered symbiotic bacteria.
The paratenic hosts reveal a case of scabies in the Traveling Salesman, and discuss a role for natural antibody in protection from infection with Plasmodium.
Vincent and Dickson discuss how malaria parasites induce odors in their rodent hosts that attract mosquitoes.
Vincent and Dickson review three novel approaches to antimalarial chemotherapy.
Vincent and Dickson reveal how malaria parasites avoid lysis by complement in the mosquito.
Vincent and Dickson discuss control of malaria with their Columbia University colleague David Fidock.
Vincent and Dickson discuss control of malaria and filariasis with the bacterial endosymbiont Wolbachia.
Vincent and Dickson review an in silico pipeline for identifying molecular mimicry candidate proteins in the genomes of parasites, and catch up on listener email.