TWiM explains a new mechanism for preventing lysogeny through temperate phage-antibiotic synergy, and Salmonella expansion in the murine gut dependency on aspartate derived from reactive oxygen species-mediated microbiota lysis.
TWiM describes the mechanism for the S. aureus itch and scratch induced skin damage, and discovery of a novel class of antibiotics that targets the lipopolysaccharide transporter.
On the occasion of TWiM’s 300th episode, we discuss how two college students found a new antibiotic in soil, Barbara Iglewski’s passing, and Elio returns for an appearance.
TWiM explains how phages avoid tRNA-targeting host defenses, and discovery of a new antibiotic from an uncultured bacterium that binds to an immutable target.
TWiM reviews discovery of a bacterium that is visible to the naked eye, and reversible resistance to bacteriophage by shedding of the bacterial cell wall.
The Microbial Comrades present the oldest osteosynthesis in history, and how a small molecule produced by stressed bacteria is a warning signal that repels healthy populations to promote their survival.
Insight into the biology of rhinovirus C from cryo-electron microscopy, and a novel antibiotic from a commensal bacterium that grows in the human nose, from the doctors of TWiM.
The arrival in the US of plasmid-mediated resistance to colistin antibiotics, a last line of defense against many gram-negative bacilli, and a quorum sensing system in a eukaryote are topics of this episode hosted by Vincent, Michael, and Michele.
The TWiM team focuses on the gut microbiome, from a single member, Akkermansia muciniphila, to the effect of antibiotics on its composition and colonization resistance against C. difficile.
Vincent and Michael discuss the highly diverse microbiome of uncontacted Amerindians, and how the composition of human urine plays a role in the battle for iron. Right click to download TWiM#107 (44 MB .mp3, 91 minutes). Subscribe…
The Hosts of TWiM
Petra Levin, Ph.D.
Michele Swanson, Ph.D.
Michael G. Schmidt, Ph.D.
Vincent Racaniello, Ph.D.