TWiV 458: Saliva of the fittest

September 9, 2017

subgenomic flavivirus RNAThe TWiVians present an imported case of yellow fever in New York City, and explain how a dengue virus subgenomic RNA disrupts immunity in mosquito salivary glands to increase virus replication.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

Click arrow to play
Download TWiV 458 (72 MB .mp3, 119 min)
Subscribe (free): iTunesRSSemail

Become a patron of TWiV!

Links for this episode

This episode is brought to you by the Defense Threat Reduction Agency. Part of the U.S. Department of Defense, the Agency’s Chemical and Biological Technologies Department hosts the 2017 Chemical and Biological Defense Science & Technology Conference to exchange information on the latest and most dynamic developments for countering chemical and biological weapons of mass destruction. Find out more at

Weekly Science Picks

Kathy – Antibody validation Editorial Asilomar meeting report
AlanNOAA Hurricane Hunters
Rich – Awakenings by Oliver Sacks (encephalitis lethargica)
Vincent – Goodnight Lab by Chris Ferrie

Listener Picks

Pete – Change Agent by Daniel Suarez
Pasteur’s Gambit by Stephen Dando-Collins
Maureen – Discovery Documentary First in Human

Intro music is by Ronald Jenkees.

Send your virology questions and comments to

Leave a Reply

Your email address will not be published. Required fields are marked *

3 comments on “TWiV 458: Saliva of the fittest

  1. et carter Sep 14, 2017

    I was so happy to be able to agree with secular science in my research. My first letter before the Ebola virus was along the lines of: “What is the most dangerous living creatures for it’s size to the entire world?…after some laughing at me (good naturedly by one of them before the deadly Ebola outbreak)) answer was the mosquito. I stand by that vampiric vector in the face of post-modern science to this day… et carter