Tag: RdRp

TWiV 819: How to stall a copy machine

October 21, 2021
Tagged as: coronavirus, COVID-19, pandemic, RdRp, remdesivir, RNA dependent RNA polymerase, SARS-CoV-2, viral, virology, virus, viruses

TWiV explains how remdesivir inhibits the SARS-CoV-2 RNA polymerase: the drug is incorporated into the growing RNA chain and causes synthesis to stall when the drug clashes with an amino acid in the active site.

TWiV 555: Fidelity and the single cell

July 7, 2019
Tagged as: error catastrophe, error threshold, polymerase fidelity, quasispecies, RdRp, ribavirin, RNA catalysis, RNA polymerase, single cell virology, viral, virology, virus, viruses

From ASM Microbe 2019, Vincent, Brianne and Calvin meet up with Craig Cameron to discuss his career and his work exploring RNA-dependent RNA synthesis and single cell virology.

The TWiV hosts discuss the distribution of prions in the eyes of patients with sporadic Creutzfeldt-Jacob disease, and the origins and evolution of RNA viruses.

The TWiVocateurs discuss how the RNA polymerase of enteroviruses binds a component of the splicing machinery and inhibits mRNA processing.

Tag: RdRp

TWiV 819: How to stall a copy machine

TWiV 555: Fidelity and the single cell

TWiV 526: In the beginning there was pol

TWiV 328: Lariat tricks in 3D

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Inside a BSL-4 laboratory