The TWiV team covers outbreaks of eastern equine encephalitis virus in the US and poliovirus in the Philippines, and explain how a chemokine induced by HIV-1 infection helps release more virus particles from cells.
Vincent speaks with David Oshinsky, the Pulitzer Prize-winning author of Polio: An American Story, about the history of poliovirus vaccines.
TWiV 459: Polio turns over a new leaf
- September 17, 2017
- Tagged as: accidental exposure, acute lymphoblastic leukemia, Agrobacterium, CAR, chimeric antigen receptor, empty capsid, gene therapy, inactivated polio vaccine, IPV, Kymriah, lentivirus vector, Nicotiana, plant, poliovirus, tobacco, Vaccine, viral, virology, virus, virus-like particle, vlp
The TWiV team reviews the first FDA approved gene therapy, accidental exposure to poliovirus type 2 in a manufacturing plant, and production of a candidate poliovirus vaccine in plants.
The TWiV team takes on an experimental plant-based poliovirus vaccine, contradictory findings on the efficacy of Flumist, waning protection conferred by Zostavax, a new adjuvanted subunit zoster vaccine.
Vincent speaks with Julius about his long career in virology, including his crucial work as part of the team at the University of Pittsburgh that developed the Salk inactivated poliovirus vaccine.
TWiV 371: Sympathy for the devil
- January 10, 2016
- Tagged as: attenuation, circulating vaccine-derived poliovirus, eradication, inactivated poliovaccine, IPV, microsatellite DNA, neurovirulence, OPV, oral poliovaccine, poliovirus, reversion, Tasmanian devil, Tasmanian devil facial tumor, transmissible cancer, vaccine seed strain, viral, virology, virus, viruses
The TWiVologists discuss the finding of a second transmissible cancer in Tasmanian devils, and development of new poliovirus strains for the production of inactivated vaccine in the post-eradication era.
Vincent meets up with Peter L. Salk to talk about development of the first poliovaccine, eradication of poliomyelitis, and Jonas Salk’s 100th birth anniversary.
TWiV 2: Polio is not dead
- September 26, 2008
- Tagged as: flaccid paralysis, IPV, OPV, paralysis, Polio, poliomyelitis, poliovirus, Sabin, Salk, Vaccine, viral, virology, virus, viruses
Vincent and Dickson discuss the biology and pathogenesis of poliovirus infection and the plan to eradicate the virus from the planet.