epitope | This Week in Virology

TWiV 796: The vary hungry spike with Paul and Theodora

August 22, 2021
Tagged as: antibody, coronavirus, COVID-19, epitope, pandemic, polymutant spike, SARS-CoV-2, spike protein, vaccine booster, viral, virology, virus, viruses

Paul and Theodora return to TWiV to explain their research on determining the number of neutralizing epitopes on the SARS-CoV-2 spike that are recognized by antibodies, and engineering of a polymutant spike with twenty amino acid changes that demonstrates the high genetic barrier to escape from convalescent serum.

Alessandro Sette joins TWiV to discuss the role of T cells in COVID-19, the finding that amino acid changes in SARS-CoV-2 variants of concern have a negligible impact on T cell reactivity in convalescent patients and vaccinees, and whether a next generation vaccine should include more viral proteins than spike.

TWiV 550: Covering up the shiny parts

June 2, 2019
Tagged as: antigenic hole, broadly neutralizing antibodies, epitope, herpes simplex virus, immunofocusing, latency, neuronal cell line, reactivation, universal influenza vaccine, Vaccine, viral, virology, virus, viruses

TWiV explains the use of a neuronal cell line to study herpes simplex virus latency and reactivation, and a strategy for creating vaccines that induce antibodies against specific epitopes.

TWiV 467: Jon and Ted’s Excellent Adventure

November 12, 2017
Tagged as: AID, biomedical research, class switch recombination, defective ribosomal products, DRiP, epitope, immunodominance, influenza virus, lamprey, monoclonal antibody, viral, virology, virus, Yewdell

Jon and Teddy Yewdell join the TWiV team to talk about their careers, their research, and the problems with biomedical research.

Tag: epitope

TWiV 796: The vary hungry spike with Paul and Theodora

TWiV 736: Rhapsody in T with Alessandro Sette

TWiV 550: Covering up the shiny parts

TWiV 467: Jon and Ted’s Excellent Adventure

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Inside a BSL-4 laboratory