TWiV 200: Threading the NEIDL

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Elke Mühlberger, Paul Duprex, and Ron Corley

Vincent, Alan, and Rich celebrate the 200th episode of TWiV by visiting the National Emerging Infectious Diseases Laboratories at Boston University Medical Center, where they meet with Elke, Paul, and Ron to talk about building and working in a BSL4 facility.



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Weekly Science Picks

Alan – Dance your Ph.D.
Rich – Angel of Death by Gareth Williams
 Vincent – Why herpesvirus is good for you (Virgin lab)

Listener Pick of the Week

Luis – VBORNET maps

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TWiV Team in BSL4 suits

TWiV Special: A paradigm for pathogen de-discovery

XMRVHosts: Vincent Racaniello and W. Ian Lipkin

Vincent and Ian review a multicenter blinded analysis which finds no association between chronic fatigue syndrome/myalgic encephalomyelitis and XMRV or polytropic murine leukemia virus.

Click the arrow to play, or right-click to download TWiV Special XMRV (53 MB .mp3, 44 min)

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TWiV 199: Of mice, ticks, and pigs

Amblyomma americanum tickHosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Vincent, Alan, Rich, and Kathy discuss recent outbreaks of hantavirus pulmonary syndrome in Yosemite National Park and novel swine-origin influenza in the US midwest, and isolation of the Heartland virus from two patients in Missouri with severe febrile illness.

Click the arrow above to play, or right-click to download TWiV 199 (73 MB .mp3, 101 minutes).

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Weekly Science Picks

Alan – Insane in the Chromatophores (Vimeo)
Rich – Golden Goose Awards
Kathy – Euler’s Disk (YouTube)
 Vincent – Ignorance: How it Drives Science by Stuart Firestein

Listener Pick of the Week

Adam – Leigh Van Valen

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TWiV 198: Pox has got a squeeze-box, seals are gonna sneeze all night

Red QueenHosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

Vincent, Alan, Rich, and Kathy review fatal avian influenza virus in harbor seals, and poxvirus deployment of genomic accordions to counter antiviral defenses.

Click the arrow above to play, or right-click to download TWiV 198 (71 MB .mp3, 99 minutes).

There once was a virus named pox
Whose genome contained a squeeze-box
When placed under pressure
It expanded its measure
Overcoming the new cellular blocks

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Weekly Science Picks

Alan – Getting Better: 200 Years of Medicine
Rich – Khan Academy
Kathy – Vi Hart
 Vincent – Tweet Keeper

Listener Pick of the Week

Diane – The Way We Fall by Megan Crewe
Stephen – Amateur Micrography

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TWiV 197: Cloning HeLa cells with Professor Philip I Marcus

Hosts: Vincent Racaniello and Philip I. Marcus

Vincent travels to the University of Connecticut to meet up with Professor Philip I. Marcus to discuss his development of the single cell cloning technique in the early 1950s.



Click the arrow above to play, or right-click to download TWiV 197 (51 MB .mp3, 71 minutes).

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Philip I. Marcus

TWiV 196: An arena for snakes

red tailed boa constrictorHosts: Vincent Racaniello, Alan Dove, Rich Condit, Dickson Despommier, Kathy Spindler, Mark Stenglein, and Joseph DeRisi

The TWiVites meet with Mark Stenglein and Joseph DeRisi to discuss their discovery of a novel arenavirus in snakes with inclusion body disease.

Click the arrow above to play, or right-click to download TWiV 196 (77 MB .mp3,  107 minutes).

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Weekly Science Picks

Mark – The Slow Mo Guys (Fly eats fly)
Dickson – I’m being eaten by a boa constrictor by Shel Silverstein
Alan – MMWR: First 30 years online
Rich – Giant python in Everglades and California Academy of Sciences
Kathy – Darwin finch genome sequence
 Vincent – Microbiology at Mt. Sinai

Listener Pick of the Week

Renato – Security Now podcast
Robin – The Weather
Chad – Rare protozoan from sludge (ScienceDaily)

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TWiV 195: They did it in the hot tub

Boiling Spring LakeHosts: Vincent Racaniello, Alan Dove, Rich Condit, Dickson Despommier, and Ken Stedman

The complete TWiV team meets with Ken Stedman to discuss the discovery in Boiling Spring Lake of a DNA virus with the capsid of an RNA virus.

Click the arrow above to play, or right-click to download TWiV 195 (77 MB .mp3, 107 minutes).

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Weekly Science Picks

Ken – The Edge of Life trailer and Facebook page
Dickson – The Cognitive Style of Powerpoint by Edward Tufte
Alan – SEMs of insects and spiders via Steve Gschmeissner
Rich – Curiosity Has Landed (Wiki mission summary)
 Vincent – Curiosity’s Seven Minutes of Terror (YouTube)

Listener Pick of the Week

Lance – The Vaccine Confidence Project and Immune response video (YouTube)
Anat – Beautiful Science

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TWiV 194: Five postdocs in North America

Monona TerraceHosts: Vincent Racaniello, Matthew Daugherty, Jondavid deJong, Helen Lazear, Stefan Oliver, and Cara Pager.

Vincent returns to Madison, Wisconsin and meets with postdocs to discuss their science and their careers.

Click the arrow above to play, or right-click to download TWiV 194 (69 MB .mp3, 94 minutes).

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TWiV 193: Live at ASV in Madison

ASV Madison 2012Hosts: Vincent Racaniello, Rich Condit, Carolyn Coyne, and Sara Sawyer

Vincent, Rich, Carolyn, and Sara recorded TWiV at the 31st Annual Meeting of the American Society for Virology in Madison, where they discussed genetic conflict between viral and human genes, and how the placenta protects the fetus against viral infection.

Click the arrow above to play, or right-click to download TWiV 193 (56 MB .mp3,  78 minutes).

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Weekly Science Picks

Rich – Benjamin Franklin: An American Life by Walter Isaacson
 Vincent – Biochemistry Revealed

Listener Pick of the Week

Matlock – The BioDigital Human
Matt – Scientists create jellyfish from rat cells

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TWiV 192: Viral tertulia

radar beeHosts: Vincent Racaniello, Alan Dove, and Rich Condit

Vincent, Alan, and Rich answer listener email about bioinformatics, insects, influenza, laboratory classes, commensalism, reproducibility of data, and more.

Click the arrow above to play, or right-click to download TWiV 192 (84 MB .mp3, 117 minutes).

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Weekly Science Picks

Alan – The Microbial Olympics (supplementary information)
Rich – PharmaJet needle free injection system
 Vincent – Microbes and Evolution by Roberto Kolter and Stanley Maloy (paperback and Kindle)

Listener Pick of the Week

Varun – Agile Gene by Matt Ridley
Sizun – Plague Inc
Ricardo – TED-ED
Kristopher – Ed Yong on Econtalk

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The Hosts of TWiV

Vincent Racaniello, Ph.D.


Dickson D.
Despommier, Ph.D.


Alan Dove, Ph.D.


Daniel Griffin, M.D.,
Ph.D., CTropMed CTH


Jolene Ramsey, Ph.D.


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