TWiV 1160: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin informs us about mpox circulation, the Marburg virus outbreak in Rwanda, new recommendations for the RSV and pneumococcal vaccines by the CDC, the beginning of influenza season, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, contrasting public health concerns between the US and the UK, what the risk of SARS-CoV-2 transmission is when indoors, the difference between NVX-CoV2327 and BNT162b2 for adolescents, why 65 years and older should get a second boost of the COVID-19 vaccine, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, the clinical trial for evaluating how novel treatments of COVID-19 affect long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome after SARS-CoV-2 infection.

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  • Grim marker: mpox over a 1000 deaths in Africa (CIDRAP) 1:28
  • Global trend of mpox outbreak 2022-2024 (WHO)
  • Second time mpox is a global public health emergency (Reuters)
  • Mpox variant in Germany (Reuters) 1:45
  • Epidemiological analysis of confirmed mpox cases in Burundi (EuroSurveillance) 3:31
  • The 63rd case of Marburg virus infections in Rwanda (CIDRAP) 7:31
  • How to stop Marburg virus (Rwanda Biomedical Centre)
  • Marburg virus fact sheet (Rwanda Biomedical Centre)
  • FDA approves RSV vaccine ABRYSVO for 18-59 individuals of increased risk (Pfizer) 8:35
  • Respiratory syncytial virus infection-NET (CDC)
  • New pneumococcal vaccine recommendations…..it’s a virus? (CDC Newsroom)
  • Recommending PREVNAR 20, 20 valent pneumococcal conjugate vaccine for 50 and over (Pfizer) 10:54
  • And one more, CAPVEXIVE, pneumococcal 21 valent conjugate vaccine (Merck)
  • Penumococcoal 21-valent conjugate vaccine CAPVEXIVE (MerckVaccines.com)
  • Influenza surveillance: Key updates (CDC) 13:14
  • COVID-19 deaths (CDC)
  • COVID-19 national and regional trends (CDC) 13:32
  • Waste water scan for 11 pathogens (WastewaterSCan)
  • What is happening across the pond? (UKHSA data dashboard) 14:27
  • COVID-19 variant tracker (CDC) 15:20
  • SARS-CoV-2 genomes galore (Nextstrain)
  • Risk of SARS-CoV-2 transmission when indoors (JID) 15:59
  • NVX-CoV2327 vs BNT162b2 vaccines in adolescents (Pediatric Infectious Disease Journal) 21:32
  • Second dose of 2024-2025 COVID19 vaccine recommended for 65 and older (CDC Newsroom) 23:27
  • New preventive COVID-19 agent (ISDA)
  • IDSA Guidelines on the Treatment and Management of Patients with COVID-19 (IDSA)
  • Where to get pemgarda (Pemgarda)
  • EUA for the pre-exposure prophylaxis of COVID-19 (INVIYD)
  • CDC Quarantine guidelines (CDC)
  • NIH COVID-19 treatment guidelines (NIH)
  • Infectious Disease Society guidelines for treatment and management (ID Society)
  • Viral and symptom rebound following monoclonal antibody therapy (JID) 24:45
  • Drug interaction checker (University of Liverpool)
  • Molnupiravir safety and efficacy (JMV)
  • Convalescent plasma recommendation for immunocompromised (ID Society)
  • What to do when sick with a respiratory virus (CDC)
  • When your healthcare provider is infected/exposed with SARS-CoV-2 (CDC)
  • Managing healthcare staffing shortages (CDC)
  • Steroids, dexamethasone at the right time (OFID)
  • Anticoagulation guidelines (hematology.org)
  • ASH living guidelines on use of anticoagulation for thromboprophylaxis in patients with COVID-19: executive summary, Dr. Daniel Griffin (Blood Advances) 26:24
  • Novel treatments for acute COVID-19 should account for long COVID (JID) 28:09
  • The persistence of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) after SARS-CoV-2 infection (Journal of Infection) 30:03
  • Letters read on TWiV 1160 32:35
  • Dr. Griffin’s COVID treatment summary (pdf)
  • Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV 1159: Eliminating cervical cancer, and endometrial immunity

Vincent travels to the Karolinska Institute in Stockholm to meet up with Niklas Björkström and Joakim Dillner to review their research on the endometrial immune system, and the plan to eliminate cervical cancer in Sweden.

Host: Vincent Racaniello

Guests: Niklas Björkström and Joakim Dillner

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Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Content in this podcast should not be construed as medical advice.

TWiV 1158: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin informs us about mpox circulation and new vaccine approval, the Marburg virus outbreak in Rwanda, and the largest outbreak of whooping cough in a decade before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, immunity among those over 65th following the 3rd dose of the COVID-19 mRNA vaccine, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, how well the SARS-CoV-2 rapid antigen test performed, what do when healthcare workers succumb to SARS-CoV-2 infection, the effect of remdesivir on survival and readmission of hospitalized patients, if cognitive impairment following virus infection impairs one’s driving and how long COVID affects Chinese society.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV 1157: Superworm liquefaction and a pandemic prophylactic

TWiV reviews Marburg virus outbreak in Rwanda, cryo-EM based discovery of a parvovirus causing black wasting disease in farmed beetles, and a mosaic nanoparticle experimental vaccine that elicits cross-reactive sarbecovirus responses in pre-vaccinated animals.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

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Weekly Picks 1:22:35

Brianne – ASM Lesson Plans
Alan – A City on Mars, and this blog by a ham radio operator hit by Hurricane Helene
Vincent – How to Win A Nobel Prize

Listener Pick

Laura – Science of Public Communication (original article)

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Content in this podcast should not be construed as medical advice.

TWiV 1156: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin updates us about polio SIA campaign in Gaza, the durability of protection following administration of GSK’s recombinant antigen RSV vaccine, mpox in an Ugandan jail, the Marburg virus outbreak in Rwanda, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, immunogenicity, reactogenicity and safety of different COVID-19 vaccine platforms, disease severity in those not previously vaccinated with those vaccinated but not infected, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if COVID-19 doubles the risk for heart attacks, stroke and death and if COVID-19 affects the regions of the brainstem.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV 1155: Spillover in stall A

TWiV reviews mask effectiveness against respiratory infections, EEE death in NY State, viruses with zoonotic potential in farmed fur animals, and genetic tracing of market wild life and viruses at the Huanan Seafood Market, the epicenter of the COVID-19 pandemic.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

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Weekly Picks 1:20:50

Rich – Immunize.org, Vaccineinformation.org, National Network of Immunization Coalitions
Alan – Birdcast
Vincent – A universal framework for inclusive 15-minute cities

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Content in this podcast should not be construed as medical advice.

TWiV 1154: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses the Marburg virus outbreak in Rwanda, the lack of immune durability following pertussis vaccination, recommendations for maternal vaccination and antibody therapy to protect against infant RSV, vaccine security for Mpox, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, how to put on and take off PPE to avoid contamination, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, the lack of immune durability elicited by mRNA vaccine and the finding of how SARS-CoV-2 infection impacts memory, cognition and reduces grey matter volume.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV 1153: Viruses that (can) make you well

From the Viruses of Microbes meeting in Cairns, Australia, TWiV speaks with Krystyna and Rob about their research on using bacteriophages to treat bacterial infections.

Hosts: Vincent Racaniello and Jolene Ramsey

Guests: Krystyna Dabrowska and Rob Lavigne

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Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Content in this podcast should not be construed as medical advice.

TWiV 1152: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin deep dives into the durability of the antibody response following mpox vaccination, vaccine security, global mpox circulation, the origins of SARS-CoV-2, including a list TWiV episodes and combatting scientific misinformation, before reviewing the recent statistics on SARS-CoV-2 infection, the WasterwaterScan dashboard, where to find PEMGARDA, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if remdesivir + dexamethasone lowers mortality of hospitalized COVID-19 patients and the finding of how SARS-CoV-2 infection impacts memory and cognition.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV 1151: Hotel California for Phage

TWiV reviews polio vaccination campaign in Gaza, viruses with zoonotic potential in farmed fur animals, low HPV vaccination in North Texas associated with high rates of cervical cancer, a large flavivirus genome that does not encode error correction machinery, and antiphage defense through inhibition of virion assembly.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Jolene Ramsey

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Weekly Picks 1:33:45

Dickson – Digital nature pics winners 2024 Wildlife Photographer of the Year
Alan – Adorable story about a Nigerian paralympian couple who are both polio survivors
Jolene – Capsid assembly model with self-assembling pentamers in 3D print model (plus three more models now available if search self assembling virus) and Wonderlab article about exhibit using this to teach about viral patterns in Bloomington Indiana Science museum
Vincent – The collapse of bat populations led to more than a thousand infant deaths

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

Content in this podcast should not be construed as medical advice.

The Hosts of TWiV

Vincent Racaniello, Ph.D.


Brianne Barker, Ph.D.


Rich Condit, Ph.D.


Alan Dove, Ph.D.


Daniel Griffin, M.D.,
Ph.D., CTropMed CTH


Angela Mingarelli, DVM


Jolene Ramsey, Ph.D.


Kathy Spindler, Ph.D.


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