In his weekly clinical update, Dr. Griffin discusses the use of RSV vaccines in older adults: recommendations of the advisory committee on immunization practices, case report of leprosy in Central Florida, blood group A enhances SARS-CoV-2 infection, predicting COVID-19 incidence using wastewater surveillance data, a common allele of HLA associated with asymptomatic SARS-CoV-2 infection, prevalence of low-frequency, antiviral resistance variants in SARS-CoV-2 isolates in Ontario, Canada, viral resistance analyses from the Remdesivir phase 3 adaptive COVID-19 treatment trial-1, impact of Molnupiravir treatment on patient-reported COVID-19 symptoms in the phase 3 move-out trial, Molnupiravir for treatment of adults with mild or moderate COVID-19, delayed intubation associated with in-hospital mortality in patients with COVID-19 respiratory failure who fail heated and humified high flow nasal canula, relationship between azithromycin and cardiovascular outcomes in unvaccinated patients with COVID‐19 and preexisting cardiovascular disease, and the effects of COVID-19 on cognitive performance in a community-based cohort, clinical phenotypes and quality of life to define post-COVID-19 syndrome.

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Intro music is by Ronald Jenkees

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David Tuller returns to TWiV to provide an update on ME/CFS, the PACE trial, developments related to the NICE guidelines, and how similar practices and ideologies are being applied to long COVID.

Host: Vincent Racaniello

Guest: David Tuller

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Download TWiV 1029 (44 MB .mp3, 61 min)
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Intro music is by Ronald Jenkees

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TWiV reviews approvals of the first gene therapy for severe hemophilia A in adults and a monoclonal antibody to prevent RSV respiratory disease in babies and toddlers, and a common allele of HLA that mediates asymptomatic SARS-CoV-2 infection through pre-existing T cell immunity due to previous exposure to common cold coronaviruses.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:35:48

DicksonPhoenix hits 110 degrees for the 19th day in a row, setting national record
Brianne James Webb Telescope One Year Anniversary Photo
Kathy Drone awards photos
AlanWHO Film Festival winners
VincentThinking, Fast and Slow by Daniel Kahneman

Listener Picks

DavidThe Mass Extinction Debates: A Science Communication Odyssey

Intro music is by Ronald Jenkees

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In his weekly clinical update, Dr. Griffin discusses the transmission of SARS-CoV-2 in free-ranging white-tailed deer in the United States, Omicron subvariant BA.5 efficiently infects lung cells, COVID-19 scent dog research highlights and synthesis during the pandemic of December 2019, T-Cell Immunity against SARS-CoV-2 measured by an interferon-γ release assay is strongly associated with patient outcomes in vaccinated persons hospitalized with Delta or Omicron variants, a common allele of HLA is associated with asymptomatic SARS-CoV-2 infection, and the immunology of long COVID.

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  • Transmission of SARS-CoV-2 in white-tailed deer in the United States (Nature) 6:45
  • Omicron subvariant BA.5 efficiently infects lung cells (Nature) 7:28
  • COVID-19 scent dog research highlights during the pandemic of December 2019 (JOM) 9:59
  • T-Cell Immunity against SARS-CoV-2 measured by an interferon-γ release assay is strongly associated with patient outcomes (JID) 14:00
  • Common allele of HLA is associated with asymptomatic SARS-CoV-2 infection (Nature) 19:45
  • Immunology of long COVID (Nature) 29:55
  • Contribute to our FIMRC fundraiser at PWB 32:01
  • Letters read on TWiV 1027 32:29
  • Dr. Griffin’s COVID treatment summary (pdf)
  • Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

Dan Wilson returns to TWiV to debunk vaccine misinformation by RFK Jr. during his recent appearance on the Joe Rogan Experience.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

Guest: Dan Wilson

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Weekly Picks 1:41:42

Dickson – Jazz G.O.A.T.S – Louis Armstrong, Duke Ellington, Ella Fitzgerald
Brianne Defining the Anthropocene?
Kathy How to use your thermostat on A/C
RichStar Trek: Strange New Worlds
VincentStep Aside, Joe Biden

Listener Picks

KimVirus found in a boreal lake links ssDNA and dsDNA viruses and Structure of ssDNA bacteriophage ΦCjT23 provides insight into early virus evolution

Intro music is by Ronald Jenkees

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In his weekly clinical update, Dr. Griffin discusses the new risk assessment for the H5N1 avian flu viruses, the development of monoclonal antibody-based blocking ELISA for detecting SARS-CoV-2 exposure in animals, repeated antibiotic exposure and risk of hospitalization and death following COVID-19 infection, COVID-19 rebound study: a prospective cohort study to evaluate viral and symptom rebound differences in participants treated with Nirmatrelvir plus Ritonavir versus untreated controls, exaggerated blood pressure elevation in response to orthostatic challenge a post-acute sequelae of SARS-CoV-2 infection (PASC) after hospitalization, long term follow-up of a multicenter cohort of COVID-19 patients with pulmonary embolism, and risk of cardiovascular disease after COVID‐19 diagnosis among adults with and without diabetes.

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Download TWiV 1025 (21 MB .mp3, 35 min)

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Intro music is by Ronald Jenkees

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Vincent speaks with Kostya Chumakov about his career: raised by two virology parents in Moscow, trained in virology by Vadim Agol, then moving to the US FDA where he developed a molecular test for measuring production consistency of oral poliovirus vaccine.

Host: Vincent Racaniello

Guest: Kostya Chumakov

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Katherine joins TWiV to discuss her career in science writing, from not liking science at all, to a PhD in microbiology and immunology, and writing for Nova, the NY Times, and The Atlantic, and how the COVID-19 pandemic has impacted her craft.

Host: Vincent Racaniello, Kathy Spindler, and Brianne Barker

Guest: Katherine Wu

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Weekly Picks 1:23:12

Brianne- Maropeng caves and Finding Homo naledi
Kathy – Being Mary Tyler Moore
VincentGoogle Isn’t Grad School

Listener Picks

JohnA new study found people are terrible at sitting alone with their thoughts.
AlanWhat if all viruses vanished?

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In his weekly clinical update, Dr. Griffin discusses autochthonous leprosy in the United States, a systematic review to identify novel clinical characteristics of Mpox virus infection and therapeutic and preventive strategies to combat the virus, two-year duration of immunity of inactivated poliovirus vaccine, evaluation of novel oral polio vaccine type 2 SIA impact in a large outbreak of circulating vaccine-derived poliovirus in Nigeria, performance of rapid antigen tests to detect symptomatic and asymptomatic SARS-CoV-2 Infection, effectiveness of the COVID-19 bivalent vaccine, oral Nirmatrelvir and Ritonavir for COVID-19 in vaccinated, non-hospitalized adults ages 18-50 years, genome-wide association study of long COVID, vaccination ameliorates cellular inflammatory responses in SARS-CoV-2 breakthrough infections, and high incidence of autonomic dysfunction and postural orthostatic tachycardia syndrome in patients with long-COVID.

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  • Autochthonous leprosy in the United States (NEJM) 2:28
  • Systematic review to identify novel clinical characteristics of Monkeypox (Archives of Virology) 5:38
  • Two-year duration of immunity of inactivated poliovirus vaccine (JID) 8:18
  • Evaluation of novel oral polio vaccine type 2 SIA impact in a outbreak of vaccine-derived poliovirus in Nigeria (IDSA) 9:45
  • Performance of rapid antigen tests to detect symptomatic and asymptomatic SARS-CoV-2  (AIM) 11:17
  • Effectiveness of the COVID-19 bivalent vaccine (OFID) 14:51
  • Oral Nirmatrelvir and Ritonavir for COVID-19 in vaccinated, non-hospitalized adults (CID) 18:14
  • Genome-wide association study of long COVID (medRxiv) 23:36
  • Vaccination ameliorates cellular inflammatory responses in SARS-CoV-2 breakthrough infections (JID) 26:21
  • High incidence of autonomic dysfunction and postural orthostatic tachycardia syndrome in patients with long-COVID (AJM) 27:56
  • Contribute to our FIMRC fundraiser at PWB 28:42
  • Letters read on TWiV 1022 31:38
  • Dr. Griffin’s COVID treatment summary (pdf)
  • Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

From ASV 2023 in Athens, Georgia, Vincent, Kathy and Brianne speak with Trevord Bedford about his career, the development of Nextstrain.org for real-time tracking of pathogen evolution, and evolution of SARS-CoV-2 from January 2020 through Omicron.

Host: Vincent Racaniello, Kathy Spindler, and Brianne Barker

Guest: Trevor Bedford

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Download TWiV 1021 (36 MB .mp3, 60 min)
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Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv