From the European Society for Clinical Virology meeting in Milan, Vincent speaks with Eeva Broberg about her career and her work at the European Centre for Disease Prevention and Control.

Hosts: Vincent Racaniello and Heli Harvala

Guest: Eeva Broberg

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In his weekly clinical update, Dr. Griffin discusses developmental impairment in children exposed during pregnancy to maternal SARS-COV2, vagus nerve dysfunction in the post-COVID-19 condition, and humoral immunity to an endemic coronavirus is associated with postacute sequelae of COVID-19 in individuals with rheumatic diseases, incidence and burden of long COVID in Africa.

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Intro music is by Ronald Jenkees

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On this all-bacteriophage episode, TWiV explains the ‘vampire phage’, and and how mammalian cells internalize phage particles and utilize them to enhance cell growth and survival.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Jolene Ramsey

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Weekly Picks 1:30:41

DicksonBiden skips climate summit (NY Times)
RichLilium electric VTOL jet
AlanThe Far Land, by Brandon Presser
JoleneBacteriophage T4 infection watercolor painting by David Goodsell
VincentUsing narratives and storytelling to communicate science with nonexpert audiences

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DarachIt depends t-shirt

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In his weekly clinical update, Dr. Griffin discusses a microbiologist who was harassed during COVID pandemic sues university, use of inactivated poliovirus vaccine for poliovirus outbreak response, safety and immunogenicity of bivalent rsvpref vaccine coadministered with seasonal inactivated influenza vaccine in older adults, coffee as a dietary strategy to prevent SARS-CoV-2 infection, enrollment of pediatric patients in COVID-19 interventional trials, vaccination, immunity, and the changing impact of COVID-19 on infant health, COVID-19 vaccine effectiveness against post- COVID -19 condition among 589722 individuals in Sweden, repeated Omicron exposures override ancestral SARS-CoV-2 immune imprinting, protection conferred by COVID-19 vaccination, prior SARS-CoV-2 infection, or hybrid immunity against Omicron-associated severe outcomes among community-dwelling adults, the Novavax heterologous COVID booster demonstrates lower reactogenicity than mRNA vaccines, T cell responses to SARS-CoV-2 infection and vaccination are elevated in B cell deficiency and reduce risk of severe COVID-19, oral VV116 versus placebo in patients with mild-to-moderate COVID-19 in China, and how COVID-19 convalescent plasma therapy decreases inflammatory cytokines, therapeutic heparin in non-ICU patients hospitalized for COVID-19 in the ACTIV-4a trial.

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Download TWiV 1066 (32 MB .mp3, 44 min)

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TWiV reviews ban on gain-of-function research by the House, chronic wasting disease in Tennessee deer, nOPV2 causing paralysis in children, and an outbreak of feline infectious peritonitis in Cyprus caused by a new recombinant coronavirus.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 89:23

DicksonClimate Action and How to find joy in climate action
BrianneA Virus that Generates Electricity
KathyIntolerable Genius: Berkeley’s most controversial Nobel laureate
Rich – Programmed DNA Elimination (PDE): Quanta; Current Biology
AlanKBDfans mechanical keyboard kits
VincentThe Covid Vaccine Windfall Turns for Pfizer and Moderna

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MeikaIceland Eruption or not?

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In his weekly clinical update, Dr. Griffin discusses progress toward measles elimination, risk of severe coronavirus disease 2019 despite vaccination in patients requiring treatment with immune-suppressive drugs, symptoms, viral loads, and rebound among COVID-19 outpatients treated with nirmatrelvir/ritonavir compared to propensity score matched untreated individuals, late administration and corticosteroid usage explain inefficacy in COVID-19 convalescent plasma trial, higher-dose fluvoxamine and time to sustained recovery in outpatients with COVID-19, recombinant C1 inhibitor in the prevention of severe COVID-19, and Epstein-Barr virus reactivation is not causative for post-COVID-19-syndrome in individuals with asymptomatic or mild SARS-CoV-2 disease course.

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Kevin Messacar visits the Incubator to discuss his career as a pediatric infectious disease physician, and his work on enteroviruses that are associated with acute flaccid myelitis and other diseases.

Host: Vincent Racaniello

Guest: Kevin Messacar

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Download TWiV 1063 (49 MB .mp3, 68 min)
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In his weekly clinical update, Dr. Griffin discusses coverage with selected vaccines and exemption from school vaccine requirements among children in kindergarten, seasonality of endemic COVID-19, mRNA SARS-CoV-2 vaccination before vs during pregnancy and omicron infection among infants, extracting symptoms from free-text responses using ChatGPT among COVID-19 cases in Hong Kong, SARS-CoV-2 virologic rebound with nirmatrelvir–ritonavir therapy, optimization of antiviral therapy in immunocompromised COVID-19 patients, a study to learn about the study medicines (nirmatrelvir plus ritonavir) in people aged 12 years or older with COVID-19 and a compromised immune system, evaluation of the safety profile and therapeutic efficacy of Remdesivir in children with SARS-CoV-2 infection, effect of neutralizing monoclonal antibody treatment on early trajectories of virologic and immunologic biomarkers in patients hospitalized with COVID-19, and SARS-CoV-2 virologic rebound with nirmatrelvir–ritonavir therapy.

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  • Coverage with selected vaccines and exemption from school vaccine requirements among (CDC) 2:54
  • Seasonality of endemic COVID-19 (Virology) 9:36
  • mRNA SARS-CoV-2 vaccination before vs during pregnancy and Omicron infection among infants (JAMA) 13:27
  • Extracting symptoms from responses using ChatGPT among COVID-19 cases (CMI) 16:29
  • SARS-CoV-2 virologic rebound with nirmatrelvir–ritonavir therapy (AIM) 17:52
  • Optimization of antiviral therapy in immunocompromised COVID-19 patients (ClinicalTrials)
  • A study to learn about nirmatrelvir/ritonavir in people with COVID-19 and a compromised immune system (ClinicalTrials)
  • Evaluation of the safety profile and therapeutic efficacy of remdesivir in children with SARS-CoV-2 infection (EJP) 35:38
  • Effect of neutralizing monoclonal antibody treatment on virologic and immunologic biomarkers in patients with COVID-19 (JID) 36:56
  • SARS-CoV-2 virologic rebound with nirmatrelvir–ritonavir therapy (AIM)
  • Contribute to our MicrobeTV fundraiser at PWB 37:55
  • Letters read on TWiV on TWiV 1062 38:16
  • Dr. Griffin’s COVID treatment summary (pdf)
  • Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

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TWiV reveals a prediction of the expected endemic seasonality of COVID-19, based on circulation of human coronaviruses, and ecological clearance of vaccine-targeted human papillomaviruses and an increase in circulation of non-targeted virus types.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler

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Weekly Picks 1:22:40

Dickson2023 expected to be hottest year on record after warmest October ever
KathyYou can see the ISS toolbag with binoculars, Billy Collins wikipedia, What dogs think (probably)
AlanLandmark case to get sanitation declared a civil right
VincentSciComm Studios

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CharmainePetition fo National Science Appreciation Day
PeterLet’s eradicate polio this winter

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In his weekly clinical update, Dr. Griffin discusses stress in America 2023, CDC expanding testing of international air traveler samples to include flu, RSV, and other respiratory viruses, missed opportunities for preventing congenital syphilis, intrinsic and effective severity of COVID-19 cases infected with the ancestral strain and omicron BA.2 variant in Hong Kong, T-cell immunity against severe acute respiratory syndrome coronavirus 2 measured by an interferon-γ release assay is strongly associated with patient outcomes in vaccinated persons hospitalized with delta or omicron variants, masks during pandemics caused by respiratory pathogens, behavioral factors and SARS-CoV-2 transmission heterogeneity within a household cohort in Costa Rica, convalescent plasma for Covid-19–induced ARDS in mechanically ventilated patients, and olfactory and gustatory function 3 years after mild COVID-19.

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Download Download TWiV 1060 (27 MB .mp3, 38 min)

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv