TWiV 1149: Mary Estes, a gutsy virologist

From the annual meeting of the American Society for Virology, Kathy and Brianne speak with Mary Estes about her career and the research of her laboratory on viruses that infect the gastrointestinal tract, including rotavirus and norovirus.

Hosts: Kathy Spindler and Brianne Barker

Guest: Mary Estes

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Intro music is by Ronald Jenkees

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Content in this podcast should not be construed as medical advice.

TWiV 1148: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin dives into “pandemic potential” viruses isolated from farmed fur animals, how the mRNA and pox vectored vaccines against mpox spar against each other, how telehealth does managing mpox, and if prophylactic use of the anti-RSV monoclonal for infants is cost-effective before reviewing the recent statistics on SARS-CoV-2 infection, if viral load correlates to one vaccination status, where to find PEMGARDA, does administration of molnupiravir reduce symptoms in the vaccinated, when to use convalescent plasma, how molnupiravirs treatment leads to better outcomes 3 and 6 months after treatment, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, and if SARS-CoV-2 during Omicron alters ones’ micriobiota.

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Intro music is by Ronald Jenkees

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TWiV 1147: Breastmilk paradox for norovirus

TWiV reviews multi-country outbreak of Mpox, first face covering ban in Nassau County NY, case of polio in India, more in US accept vaccine misinformation, other wartime diseases in Gaza besides polio, a new scientist run virus genome database, Mpox epidemiology and vaccine effectiveness in England, and metabolic immaturity and breastmilk bile acid metabolites determine heightened newborn vulnerability to norovirus diarrhea.

Hosts: Vincent Racaniello, Rich Condit, and Brianne Barker

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Weekly Picks 1:35:26

Brianne – Viral adaptation to climate change
Rich – “Understanding the biology of monkeypox virus to prevent future outbreaks” by B. Moss
Vincent – We can now watch Grace Hopper’s famed 1982 lecture on YouTube

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

TWiV 1146: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses seasonal influenza vaccine recommendations from the CDC, polio vaccine campaign securing mpox vaccine for Africa, and donating to reduce food insecurity in mpox affected areas before reviewing the recent statistics on SARS-CoV-2 infection, where to find PEMGARDA, when to use convalescent plasma, a reminder of how and when to use steroids to treat COVID-19, what do when healthcare workers succumb to SARS-CoV-2 infection, if vaccination against SARS-CoV-2 does protect against long COVID, how fibrin drives thromboinflammation and neuropathology in COVID-19, and an evidence based approach to long COVID.

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Intro music is by Ronald Jenkees

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TWiV 1145: Heartbeats and hoofbeats

TWiV reviews a case of polio in Gaza, more Mpox, COVID-19 boosters, effectiveness of Ebola virus vaccine, measles cases across the US, an endogenous retroviral envelope protein that regulates human cardiomyocyte development, and submergence of an encephalitic alphavirus caused by receptor shifts.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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Weekly Picks 1:24:12

Kathy – Googlegangers and AWWW clip
Rich – RP FLIP (floating instrument platform)
Alan – Big labs are bad for careers
Vincent – So You’re Underwater: Why Do You See That Circle of Light Above You?

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

TWiV 1144: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses Dr. Fauci’s case of West Nile virus, polio vaccine campaign develops in Gaza, disease that associates with Oropouche virus, mpox: vaccines, clinical trial for mpox antiviral and the WHO strategic preparedness and response plan before reviewing the recent statistics on SARS-CoV-2 infection, how to obtain free COVID tests, EUA for updated Novavax COVID vaccine, ISDA support of and where to find PEMGARDA, breakthrough infections when administering PEMGARDA, when to use convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if nirmatrelvir/ritonavir is effective at preventing hospitalization of high risk patients, incidence of mental illness in the vaccinated and unvaccinated, the effect of amubarvimab/romlusevimab on long COVID outcome, having an evidence based approach to long COVID and how fibrin drives thromboinflammation and neuropathology in COVID-19.

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Intro music is by Ronald Jenkees

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TWiV 1143: SARS-CoV-2 gone wild, with a side of rice

TWiV discusses WHO declaration of Mpox as a public health emergency of international concern, Sweden reports first case of clade 1b outside of Africa, can household pets be productively infected with monkeypox virus, widespread exposure to SARS-CoV-2 in wildlife communities, and modulation of plant defenses by insect salivary GAPDH benefits viral transmission.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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Weekly Picks 1:27:00

Dickson – NASA Confirms Evidence That Liquid Water Flows on Today’s Mars
Kathy – TBP for PCR internal control
Rich –  xmACIS2 compares the data in the ACIS database to that in GHCN-Daily
Alan – Larry, the world’s most highly cited cat
Vincent – The Viral Paleontologist Who Unearths Pathogens’ Deep Histories

Listener Pick

Ryan – Mpox emergencies AP News one and two
Rona – Up in smoke
David – Ode to Joy (YouTube, TikTok)

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

TWiV 1142: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses global transmission of mpox, the different clades of the virus and associated pathogenesis, vaccination vs antiviral therapy against mpox and the US’s aid response for controlling the African outbreak before reviewing the recent statistics on SARS-CoV-2 infection, authorization and approval of updated COVID vaccines, the economic benefit of an annual COVID vaccine and if the first updated vaccines against XBB.1.5 were effective, where to find PEMGARDA, breakthrough infections when administering PEMGARDA, when to use convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and how long COVID differs in children and adolescents.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1141: Being green with the Red Queen

TWiV discusses the spread of monkeypox virus clade 1b in Africa, COVID drops to tenth leading cause of death in the US, response to detection of poliovirus in Gaza, mechanism of MIS-C after SARS-CoV-2 infection, neonatal Fc receptor is a pan-arterivirus receptor, and antiviral immunity in plants mediated by protein arginine methyltransferase 6.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

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Weekly Picks 1:28:32

Brianne – Kate Douglass: Olympian and Statistician (Swimming in Data)
Dickson – Women of recent note: Kamala Harris (Democratic Party presidential candidate); Katie Ladecky (10,000 meters); Sydney McLaughlin-Levrone (400 meter hurdles); Gabby Thomas, Sha’Carri Richardson, Melissa Jefferson, and Twanisha Terry (4 x 100 relay); women’s basketball team
Rich – Texas State University Forensic Anthropology Research Facility
Vincent – Sea lion ‘camera crews’ capture new footage of ocean floor

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

Content in this podcast should not be construed as medical advice.

TWiV 1140: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses the harms of perpetuating the lab leak hypothesis and the recent ACIP recommendations for the RSV vaccine for those individuals over 60, before reviewing the recent statistics on SARS-CoV-2 infection, treatment guidelines for the different phases of COVID, including vaccines, Pemgarda, early treatment with Paxlovid, remdesivir and molnupiravir, steroids at the right time, anticoagulation support, immune modulation in some cases, and a comprehensive definition of long COVID.

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Download TWiV 1140 (39 MB .mp3, 55 min)
Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email

Become a patron of TWiV!

Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

The Hosts of TWiV

Vincent Racaniello, Ph.D.


Brianne Barker, Ph.D.


Rich Condit, Ph.D.


Dickson D.
Despommier, Ph.D.


Alan Dove, Ph.D.


Daniel Griffin, M.D.,
Ph.D., CTropMed CTH


Angela Mingarelli, DVM


Jolene Ramsey, Ph.D.


Kathy Spindler, Ph.D.


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