In COVID-19 clinical update #117, Dr. Griffin discusses duration of virus shedding, association between pre-exposure to steroids and infection outcome, post-infection subtypes, rehabilitation for post-acute infection, Tixagevimab/Cilgavimab for infection prevention, antibody prophylaxis and vaccination in kidney transplant recipients, remdesivir and bebtelovimab fact sheets for providers, the updated guidelines on treatment with Famotidine, Paxlovid rebound symptom characterizations, antigen test positivity duration, viral dynamics of variants and isolation, association of inflammation in CS fluid, and transmission dynamics in Ghana. 

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Intro music is by Ronald Jenkees

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Vincent travels to Cold Spring Harbor Laboratory to speak with David Baltimore, John Coffin, and Harold Varmus about the discovery in 1970 of retroviral reverse transcriptase and its impact on life sciences research.

Hosts: Vincent Racaniello

Guests: David Baltimore, John Coffin, and Harold Varmus

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Intro music is by Ronald Jenkees

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In COVID-19 clinical update #115, Dr. Griffin discusses croup association with infection surge, rhinovirus co-circulation in children, shedding following vaccination, high vaccine efficacy in children 6 mo-5 yr, vaccine protection for hospitalized patients, convalescent plasma as post-exposure prophylaxis, real-world effectiveness of PAXLOVID, effectiveness of PAXLOVID in reducing hospitalization, infection rebound after PAXLOVID, relapse of symptomatic infection after PAXLOVID, remdesivir and bebtelovimab fact sheets for providers, guidelines on usage of anticoagulation drugs, long covid symptoms after vaccination, excess mortality in MA, infection sequelae and immunity, and post infection conditions among adults.

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Intro music is by Ronald Jenkees

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In this special episode, Dr. Griffin answers questions about the recent cases of monkeypox including their origin, clinical presentation, diagnosis, treatment, and overall risk.

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  • Monkeypox multi-country outbreak risk assessment (pdf, ECDC) 1:08
  • Monkeypox update (ProMedMail) 1:11
  • Monkeypox virus genome sequences (Nextstrain) 15:28

Intro music is by Ronald Jenkees

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TWiV reviews recent cases of monkeypox, presence of SARS-CoV-2 RNA but not infectious virus in feces, and the association of autoantibodies to interferons with severe COVID-19.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:48:18

DicksonHow to grow food on the moon
BrianneAPod May 16: Milky Way over French Alp Hoodoos
KathyCovid Nationwide data visualization
RichNIH All of Us Research Program
Vincent Physicians Spreading Misinformation on Social Media — Do Right and Wrong Answers Still Exist in Medicine?

Listener Pick

LisaE.H. Danner Museum of Telephony

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #115, Dr. Griffin reviews cross-variant immunity without vaccination, EUA for boosters in 5-11 year olds, B.1.1.529 attack rate, scent dogs, Omicron and pets, Paxlovid, Veklury, Fluvoxamine, antigen positivity after isolation, inflammasome activation and severe disease, and GI persistence and fecal shedding.

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Intro music is by Ronald Jenkees

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TWiV celebrates 900 episodes, Vincent gives the Richard R. Ernst lecture, and we discuss why inflammasome activation in infected macrophages drives severe COVID-19.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:17:45

BrianneThe Milky Way’s Black Hole Comes to Light
KathyRiver dolphins playing with anaconda
RichSmallpox vaccination techniques; from knives and forks to needles and pins
AlanVacuum Tubes: a Modern Aladdin’s Lamp
Vincent Books by Pamela Jane

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #114, Dr. Griffin discusses early treatment with ivermectin, procalcitonin not a reliable biomarker, vaccine in 6-11 year olds, FDA limits use of Janssen vaccine, does site of vaccine booster matter, sniffer dogs, monoclonals for hospitalized patients, risk assessment for public events, Paxlovid eligibility, and persistence of pediatric anosmia.

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Intro music is by Ronald Jenkees

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TWiV explains why the concept of herd immunity might not apply to COVID-19, and the observation that smallpox vaccination causes an increase in skin bacteria that promote pathology and influence the immune response.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:27:50

BrianneBacteria and Me Coloring Book
KathySmarter 3D printing
RichBig Ben Restoring the Worlds Most Famous Clock 2021
Vincent Scientific review articles as antivaccine disinformation

Listener Pick

SuellenYour Fantastic Mind Season 3 Ep 2: Long COVID and Making of a Brain Surgeon (Full Episode)

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #113, Dr. Griffin discusses tocilizumab use in hospitalized Patients, IL-6 inhibitors and mortality, Baricitinib in hospitalized patients, post-infection neurological sequelae, comparative effectiveness of Pfizer and Moderna vaccines, phase 2/3 study of Paxlovid, infection relapse following Paxlovid, pre-hospital administration of Remdesivir, and hospitalization with different variants.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv