In COVID-19 clinical update #78, Daniel Griffin covers ivermectin, convalescent plasma, disease in pregnant women, children and COVID, delta outbreak in an elementary school, validation of at-home antigen test, shedding in infected vaccinated people, mRNA vaccine antibody responses compared, AZD7442, fluvoxamine, one year outcomes in hospitalized patients, and post-vaccination disease.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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TWiV reviews models for determining correlates of neutralizing antibody protection against COVID-19, and for identifying key vector and host species that drive transmission of zoonotic pathogens.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:58:07

BrianneA microscopic video shows the coronavirus on the rampage
KathySabin Oral Sundays in Cuyahoga County, 1962
RichThe Continuing COVID-19 Pandemic: Current Issues and Glimpse Into the Future
VincentDemand Surges for Deworming Drug for Covid, Despite Scant Evidence It Works

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RonaldImmunity to COVID-19 could last longer than you’d think
AgnesSpace Shuttle Prints

Intro music is by Ronald Jenkees

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The TWiV team explains what the Biden report on SARS-CoV-2 origins did not: evidence that the virus came from Nature, not a lab; and reveals new coronaviruses in rodents that inhabit populated areas in southern China.

Hosts: Vincent Racaniello, Alan Dove, Dickson Despommier, Rich Condit, and Kathy Spindler

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Weekly Picks 1:32:46

DicksonThe Brilliant Abyss by Helen Scales
KathySolar System ball drop
RichDr. Fox effect
Alan – Patty Wagstaff virtual airshow cockpit video
VincentOffice Hours

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KarenThe Dog Will See You Now
AliciaBio-Rad GTCA Song

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #77, Daniel Griffin discusses children becoming increasingly infected, virological characteristics of infections in vaccinated health care workers, transmission dynamics among close contacts, licensing of Pfizer mRNA vaccine, cost of hospitalization of unvaccinated patients, 29 times higher hospitalization rates in unvaccinated patients, boost in neutralizing antibody potency and breadth by third vaccine dose, and use of J&J vaccine as second dose.

Hosts: Daniel Griffin and Vincent Racaniello

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Intro music is by Ronald Jenkees

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Paul and Theodora return to TWiV to explain their research on determining the number of neutralizing epitopes on the SARS-CoV-2 spike that are recognized by antibodies, and engineering of a polymutant spike with twenty amino acid changes that demonstrates the high genetic barrier to escape from convalescent serum.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Brianne Barker

Guests: Paul Bieniasz and Theodora Hatiziiouannou

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Weekly Picks 1:37:12

DicksonNIF and Photon Science: fusion reaction generates 1.3 MJ
BrianneThe PCR Song
Rich – 1) How Boston Dynamics’ Spot Robot Works! 2) Inside the lab: How does Atlas work? 3) Atlas | Partners in Parkour
Theodora – Kevin Parry turning into random objects
VincentLex Fridman

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #76, Daniel Griffin covers association of age and pediatric household transmission, rapid antigen testing in remote communities, shedding of infectious virus in vaccinated individuals, FDA amendment of mRNA vaccine EUA to allow a third dose, new vaccine mandate for NY state, full vaccination suppresses selection of variants, effectiveness of mRNA vaccines in nursing homes, sustained effectiveness of mRNA vaccines against hospitalization, and no benefit from early convalescent serum in high-risk outpatients.

Hosts: Daniel Griffin and Vincent Racaniello

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TWiV summarizes cases of arbovirus disease during 2019 in the US, and explains a study that estimates infectiousness throughout the SARS-CoV-2 course of infection.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Weekly Picks 1:35:48

DicksonClimate Reports | United Nations
BrianneAstronomy Picture of the Day: A Perfect Spiral
RichCOVID-19 false dichotomies
Alan – Fixing broken machines
VincentMKBHD Studio Tour 2021

Variant Vernacular by Scott

What is in a name? 
Letter? Number? Location? 
It’s all Greek to me. 

Times Are(n’t) a Changin’ 
Delta means “a change” 
But if you want a game change, 
Look to the vaccine.

Image from Anne

Intro music is by Ronald Jenkees

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In COVID-19 clinical update #75, Daniel Griffin reviews vaccine effectiveness against transmission, modeling effectiveness of daily antigen tests, updated CDC guidance for fully vaccinated, risk of infection with time after mRNA vaccination, reduced risk of infection after vaccination, therapeutic anticoagulants in critically ill patients, and 6 month outcomes in hospitalized patients.

Hosts: Daniel Griffin and Vincent Racaniello

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Jeffrey Shaman returns to TWiV to explain how epidemiologists measure SARS-CoV-2 movement among humans, including calculation of the reproductive index, secondary transmission, and what factors affect transmission.

Hosts: Vincent Racaniello, Kathy Spindler, and Brianne Barker

Guest: Jeffrey Shaman

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Weekly Picks 1:30:37

BrianneThe Social Lives of Giraffes
KathySaturn’s Iapetus, moon in 3-D
VincentArkansas Governor Wants To Reverse A Law That Forbids Schools To Require Masks

Intro music is by Ronald Jenkees

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TWiV reviews SARS-CoV-2 infection of wild white-tailed deer in the US, mRNA vaccine-mediated protection by spike-specific T cells before detection of neutralizing antibodies, and recovery from SARS-CoV-2 infection in T-cell depleted rhesus macaques.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker

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Weekly Picks 1:45:19

DicksonVirgin Hyperloop shows off the future
BrianneBioNumbers
RichAdvice will evolve as COVID situation changes
Alan – Mars Perseverance-themed geocaching swag
VincentMattel’s Barbie Turns Women Of Science, Including COVID Vaccine Developer, Into Dolls

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NancyVaccines at a Party
JeffHow to Survive a Plague, Part 2

Intro music is by Ronald Jenkees

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