In his weekly clinical update, Dr. Griffin discusses RSV vaccination recommendations and revisions to guidelines before reviewing the recent statistics on SARS-CoV-2 infection, data suggesting that individuals with high HLA-DQA2 expression (MHC class II) are better at preventing the onset of a sustained viral infection, how moderate coffee intake can reduce risk of COVID-19 severity but cannabis use resulted in more severe disease but reduced risk of mortality, where to find PEMGARDA, if statin use prevented severe COVID-19, the benefit of administering nirmatrelvir and ritonavir after 5 days, convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, if fecal microbiota transplants aid in recovery from COVID-19, and the definition of characteristics and clinical patterns for the diagnosis of long COVID.

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Intro music is by Ronald Jenkees

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TWiV reviews criticism of NIAID monkeypox virus experiments by House Republicans, spread of wild poliovirus across Afghanistan and Pakistan, plan to overhaul NIH by House lawmakers, and the potential pandemic risk of circulating swine H1N2 influenza viruses.

Hosts: Vincent Racaniello, Dickson Despommier, Brianne Barker, and Angela Mingarelli

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Weekly Picks 1:17:38

AngelaStaring at the Sun — close-up images from space rewrite solar science
BrianneWater frost detected on Mars Volcanos
DicksonBest view yet of the Crab Nebula
VincentWill Your Tattoo Give You Cancer: Probably Not…but Maybe?

Listener Picks

JessicaManchurian plague

Intro music is by Ronald Jenkees

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Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin reviews the recent statistics on SARS-CoV-2 infection, before discussing methods for sterilizing filtering facepieces, an update to the fall COVID boosters, the emergency use application of a pre-exposure prophylactic and where to find it and drug interaction database, convalescent plasma, the effectiveness of the monoclonal antibody sotrovimab against Omicron variants, what to do when healthcare workers succumb to SARS-CoV-2 infection, the need for better nursing resources, how survivors of COVID-19-associated ARDS exhibited sustained elevation in endothelial dysfunction biomarkers, correlating with the severity of impaired gas exchange, reactivation of latent CMV as a consequence of a SARS-CoV-2 infection, identification of variables that might impact or predict a person’s time to recovery from an acute SARS-CoV-2 infection and if COVID-19 patients really have olfactory dysfunction more often than normally smelling individuals.

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Download TWiV 1124 (29 MB .mp3, 40 min)
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Vincent travels to Europic 2024 in Jyväskylä, Finland to speak with Tapani Hovi and Caroline Tapparel about their careers and their research on enteroviruses and elimination of poliomyelitis.

Host: Vincent Racaniello

Guests: Tapani Hovi and Caroline Tapparel

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Download TWiV 1123 (43 MB .mp3, 60 min)
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Intro music is by Ronald Jenkees

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Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin discusses expanded use of the RSV vaccine by GSK, how the youngest member of the MicrobeTV family was hospitalized with RSV, why we are seeing more RSV infections than before the pandemic and how administration of monoclonal antibody therapy does not prevent infection but disease, before reviewing the weekly US COVID update, how SARS-CoV-2 affects neurodevelopment of the fetus and probability of preeclampsia, if giving Paxlovid prevents long COVID, and FDA recommends switching from the XBB.1.5 variant to JN.1 for fall COVID-19 vaccine formulations.

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Download TWiV 1122 (30 MB .mp3, 41 min)
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TWiV rebuts a recent opinion piece which falsely claims that the COVID-19 pandemic began in a lab (it began in Nature). This material has been extracted from TWiV 1121.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Brianne Barker, and Jolene Ramsey

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TWiV rebuts a recent opinion piece which falsely claims that the COVID-19 pandemic began in a lab (it began in Nature), followed by a discussion of Paride bacteriophage, which has the unsual property of being able to kill dormant, antibiotic-tolerant cells by direct lytic replication.

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Brianne Barker, and Jolene Ramsey

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Weekly Picks 1:38:25

BrianneHow to build a nuclear warning for 10,000 years’ time
RichDoctor My Eyes | Jackson Browne
AlanWHO Health for All Film Festival winners
JoleneEl enemigo de mi enemigo es mi amigo
VincentA Population Dotmap of New York City and Race and Ethnicity in New York City

Listener Picks

DavidThe greatest clock (and map) ever made
PeterThe Mouse as a Microscope

Intro music is by Ronald Jenkees

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Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin reports the third case of influenza H5N1 infection in a human, this time with respiratory symptoms, an H5 avian influenza virus wastewater dashboard, FDA approves Moderna’s mRNA vaccine for respiratory syncytial virus, vaccine advisors to FDA recommend switching from the XBB.1.5 variant to JN.1 for fall COVID-19 vaccine formulations, weekly US COVID update, a controlled human exhaled breath aerosol experimental study on the relative efficacy of masks and respirators as source control for viral aerosol shedding from people infected with SARS-CoV-2, systematic review of early use of oral antiviral drugs and the risk of post COVID-19 syndrome, long-COVID autonomic syndrome in working age and work ability impairment, Centers for Disease Control and Prevention estimates that 5.3% of Americans currently have long COVID, and the National Academies of Sciences, Engineering, and Medicine presented a report with  a number of conclusions about long-COVID diagnosis, symptoms, and impact on daily function.

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Download TWiV 1120 (19 MB .mp3, 32 min)
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TWiV reviews viral shedding and antibody responses of men with acute monkeypox virus infection, and gene editing for latent herpes simplex virus infection reduces viral load and shedding.

Hosts: Vincent Racaniello, Rich Condit, Kathy Spindler, and Angela Mingarelli

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Weekly Picks 1:29:10

AngelaUnconventional Sex Let Anglerfish Conquer the Deep Ocean
KathyDoonesbury from 5-26-24. And Publish or Perish game
RichSky: Giant Sunspot Region 3664 and Resulting Auroras APOD video
VincentMysterious sea urchin plague is spreading through the world’s oceans

Listener Pick

AbdulazizBiomedical Scientist Answers Pseudoscience Questions

Intro music is by Ronald Jenkees

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Content in this podcast should not be construed as medical advice.

In his weekly clinical update, Dr. Griffin delves into highly pathogenic H5N1 infection of hunting dogs, dairy cattle, humans and alpacas before reviewing the recent statistics on SARS-CoV-2 infection, risks factors associated with the development of severe COVID-19 in pediatric patients, virus transmission on commercial airline flights, the guidelines for spring administration of COVID vaccines boosters, the emergency use application of a pre-exposure prophylactic, a drug interaction database, absence of durability of XBB.1.15 vaccine induced immunity and continues to dispel the myth of viral rebound, when to use steroids and the benefits of convalescent plasma, what do when healthcare workers succumb to SARS-CoV-2 infection, and discusses why development of long COVID should be included in the development of treatments for acute viral disease, if vaccination effects long COVID, structural impairment of brain during long COVID, how cognitive and respiratory function may be compromised in long COVID.  For more information about long COVID-19 listen to TWiV 1088 and for H5N1 in dairy cattle and unpasteurized milk TWiV 1117.

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Download TWiV 1118 (30 MB .mp3, 51 min)
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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv