TWiV 983: One flu vaccine for them all with Scott Hensley

Scott returns to TWiV to explain the development of an experimental mRNA vaccine that encodes hemagglutinin antigens against all known influenza A virus subtypes and influenza B virus lineages, and why he is worried about avian H5N1 influenza virus.

Hosts: Vincent Racaniello, Dickson Despommier, and Brianne Barker

Guest: Scott Hensley

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•Research assistant position at FDA (pdf) 4:17
•Register for ASV 2023 4:55
•MicrobeTV Discord Server 6:43
•Multivalent influenza mRNA vaccine (Science) 9:29
•Influenza virus mRNA vaccines circumvent egg adaptation problems (J Virol) 17:58
•Letters read on TWiV 983 1:23:17
•Timestamps by Jolene. Thanks!

Weekly Picks 1:35:03

Dickson – Jazz Project:  Guitar. Django Reinhardt; Pat Metheny. Signature album: Still Life Talking. Signature song: Last Train Home; Joe Pass (Ella Fitzgerald’s favorite guitar accompanist). Signature album: Virtuoso. Signature song: Round Midnight.
Brianne – HHMI Virus Explorer
Vincent – Chris Luno

Listener Picks

John – White-tail deer density and SARS-CoV-2 in white-tail deer
Jessica – Classic cases revisited: Oscar the cat and predicting death

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

TWiV 982: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses the consistency of COVID-19 trial preprints with published reports and impact for decision making, the negative effect of preexisting immunity on Influenza vaccine responses transcends the impact of vaccine formulation type and vaccination history, highly pathogenic avian influenza A(H5N1) virus infection in farmed minks in Spain, Peru confirms H5N1 avian flu in marine mammals, prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies, bacillus Calmette-Guérin vaccine for prevention of COVID-19 and other respiratory tract infections in older adults with comorbidities, incidence of chronic spontaneous urticaria following receipt of the COVID-19 vaccine booster in Switzerland, relationship between immune response to SARS-CoV2 vaccines and development of breakthrough infection in solid organ transplant recipients, early treatment with pegylated interferon lambda for COVID-19, and how long-term high-dose immunoglobulin successfully treats long COVID patients with pulmonary, neurologic, and cardiologic symptoms. 

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV 981: Tastes like chikungunya

TWiV explains the recent meeting of the National Science Advisory Board for Biosecurity (NSABB) where stricter guidelines for research involving human, animal, and plant pathogens were considered, and how the consumption of viruses by small protists returns energy to food chains.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

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•Research assistant position at FDA (pdf) 3:30
•Register for ASV 2023 4:06
•MicrobeTV Discord Server 5:01
•NSABB proposed oversight framework (pdf) 14:03, 32:45
•Stricter US guidelines for research (Nature) 32:51
•Information on NSABB (NIH)
•Consumption of viruses by protists (PNAS) 46:43
•Letters read on TWiV 981 1:12:20
•Timestamps by Jolene. Thanks!

Weekly Picks 1:27:36

Dickson – Jazz Project: Trombone: Steve Turre/Conrad Herwig; Steve Turre; Curtis Fuller; J.J. Johnson and Kai Winding. Steve Turre: Signature album: Sanctified Shells. Signature song: Sanctified Shells. Conrad Herwig. Signature album: A Jones For Bones Tones. Signature song: Slide’s Routine; Curtis Fuller: Signature album: BLUES ette. Signature song: Bluesette. J.J. Johnson (with Kai Winding). Signature album: The Great Kai and J.J. : Signature song: Monk’s Blues.
Kathy – Measles virus ‘cooperates’ with itself to cause fatal encephalitis. Primary research article: Shirogane et al.
Rich – Firm hatches plan to bring back dodo (Colossal Biosciences – Dodo)
Alan – Mt. Washington Observatory webcam
Vincent – Ask the Experts

Listener Picks

Roberto – The Contagion of Liberty: The Politics of Smallpox in the American Revolution

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

TWiV 980: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses prevalence and clinical outcomes of respiratory syncytial virus versus influenza virus in adults hospitalized with acute respiratory Illness, reconsideration of antinucleocapsid IgG antibody as a marker of SARS-CoV-2 infection postvaccination for mild COVID-19 patients, assessment of COVID-19 as the underlying cause of death among children and young people aged 0 to 19 years in the US, information for persons who are immunocompromised regarding prevention and treatment of SARS-CoV-2 Infection in the context of currently circulating Omicron sublineages, association of culturable-virus detection and household transmission of SARS-CoV-2,  effectiveness of bivalent boosters against severe Omicron infection, Covid vaccines and playing the long game, efficacy and safety of antimicrobial stewardship prospective audit and feedback in patients hospitalized with COVID-19, and severe fatigue and persistent symptoms at three months following SARS-CoV-2 Infections during the pre-Delta, Delta, and Omicron time periods.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV Special: One COVID vaccine for them all with Paul Offit

Paul Offit returns to TWiV to unpack the recent FDA Advisory Panel on COVID vaccines, with discussions on giving everyone the same bivalent vaccine, simplifying the immunization schedule, and how to know when the vaccine should be updated.

Hosts: Vincent Racaniello and Rich Condit

Guest: Paul Offit

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  • FDA briefing document (pdf) 4:07
  • Effectiveness of bivalent booster against severe infection (NEJM) 11:19
  • Timestamps by Jolene. Thanks!

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

TWiV 979: Flushing out the viroids

TWiV gives an update on poliovirus in wastewater, and reveals a vast world of viroids that infect a wide range of host species in diverse ecosystems.

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Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Kathy Spindler

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•Research assistant position at FDA (pdf) 1:58
•Register for ASV 2023 2:45
•MicrobeTV Discord Server 4:53
•Nick Muzyczka passes 1:31:39
•Wastewater testing for poliovirus (MMWR)
•NY state poliovirus wastewater surveillance (NYSDOH)
•CDC wastewater poliovirus surveillance in select communities (CDC) 10:51
•Vast world of viroid-like RNAs (Cell) 29:35
•Letters read on TWiV 979 1:12:54
•Timestamps by Jolene. Thanks!

Weekly Picks 1:30:24

Kathy – 3B new Milky Way objects, Green comet
Rich – Virology under the Microscope—a Call for Rational Discourse
Alan – Indie story-driven games series #3: Valiant Hearts: The Great War
Vincent – Vaccines and Related Biological Products Advisory Committee Meeting January 26, 2023 – pdf

Listener Picks

Florencia – An elegant way to stop deadly Hendra virus spillovers from bats to horses … to us (Nature article)

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

TWiV 978: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses co-detections of other respiratory viruses among children hospitalized with COVID-19, preprint review should form part of PhD programs and postdoc training, early and increased Influenza activity among children, COVID-19 vaccines versus pediatric hospitalization, SARS-CoV-2 variant-related abnormalities detected by prenatal MRI, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the Omicron variant and severe disease, protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease, persistent COVID-19 Symptoms at 6 months after onset and the role of vaccination before or after SARS-COV-2 infection, effect of Dexamethasone use on viral clearance among patients with COVID-19, and the impact of vaccination on post-acute sequelae of SARS CoV-2 infection in patients with rheumatic diseases.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV 977: Ageing is infectious

TWiV covers a study of SARS-CoV-2 persistence at multiple sites in the human body, and the role of endogenous retroviruses in ageing and senescence.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Brianne Barker, and Angela Mingarelli

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•Research assistant position at FDA (pdf) 2:27
•Register for ASV 2023 3:10
•MicrobeTV Discord Server 4:15
•Persistence of SARS-CoV-2 (Nature) 6:13
•Endogenous retroviruses and senescence (Cell) 29:55
•Timestamps by Jolene. Thanks!

Weekly Picks 1:26:32

Dickson – Baritone Saxophone: Gerry Mulligan. No one else comes close Signature song: Bernie’s Tune
Angela – World’s Longest Animal
Brianne – Green Comet to Pass By Earth for first time in 50,000 years
Alan – Indie games series: Golf Club Wasteland
Vincent – Bivalent Covid-19 Vaccines — A Cautionary Tale

Listener Picks

Lisa – The River and the Wall

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

TWiV 976: Clinical update with Dr. Daniel Griffin

In his weekly clinical update Dr. Griffin discusses China reporting almost 60,000 Covid-related deaths after abrupt shift in policy, detection of SARS-CoV-2 IgA and IgG in human milk and breastfeeding infant stool 6 months after maternal COVID-19 vaccination, effect of Fluvoxamine vs placebo on time to sustained recovery in outpatients with mild to moderate COVID-19, hyperimmune globulin for severely immunocompromised patients hospitalized with COVID-19, long COVID outcomes at one year after mild SARS-CoV-2 infection, long COVID: major findings, mechanisms and recommendations, a systematic review of trials currently investigating therapeutic modalities for post-acute COVID-19 syndrome and registered on World Health Organization international clinical trials platform, and the effect of using a structured pacing protocol on post-exertional symptom exacerbation and health status in a longitudinal cohort with the post-COVID-19 syndrome.

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Download TWiV 976 (25 MB .mp3, 42 min)
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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to [email protected]

TWiV 975: Crossing the Ts with Daniela Weiskopf

Daniela joins TWiV to discuss her career and her research on T cells, their role in infection with SARS-CoV-2, T cell epitopes and why a variant that evades T cell immunity is not likely to emerge.

Hosts: Vincent Racaniello, Alan Dove, and Brianne Barker

Guest: Daniela Weiskopf

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Download TWiV 975 (58 MB .mp3, 98 min)
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•Research assistant position at FDA (pdf) 2:47
•Register for ASV 2023 3:36
•Cross reactive T cells to SARS-CoV-2 (Science) 25:50
•SARS-CoV-2 exposure history and T cell response (Cell Rep Med) 42:13
•Spike T cells cross- recognize Omicron (Nature) 45:05
•Ancestral SARS-CoV-2 T cells recognize Omicron (Nature)
•NVX-CoV2373 induces T cell responses (J Clin Inves) 47:23
•Letters read on TWiV 975 1:09:34
•Timestamps by Jolene. Thanks!

Weekly Picks 1:26:29

Brianne – Video of viral attachment (based on this article)
Alan – Starting a series of innovative indie video games. First up: The Longing.
Vincent – The Amy Papers and Calendar for live events

Listener Picks

Judy – Innate immune evasion strategies of SARS-CoV-2
Charles – Who’s Talking to Chris Wallace? Season 1, epitope 30: Dr. Anthony Fauci on HBO Max

Intro music is by Ronald Jenkees

Send your virology questions and comments to [email protected]

The Hosts of TWiV

Vincent Racaniello, Ph.D.


Brianne Barker, Ph.D.


Rich Condit, Ph.D.


Alan Dove, Ph.D.


Daniel Griffin, M.D.,
Ph.D., CTropMed CTH


Angela Mingarelli, DVM


Jolene Ramsey, Ph.D.


Kathy Spindler, Ph.D.


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