TWiV 1002: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses completeness and spin of medRxiv preprints and associated published abstracts of COVID-19 randomized clinical trials, lessons learned from a COVID-19 dog screening pilot in California K-12 schools, SARS-CoV-2 reinfection and severity of the disease, effectiveness of COVID-19 bivalent vaccine, Molnupiravir and risk of post-acute sequelae of COVID-19, risk of new-onset long Covid following reinfection with SARS-CoV-2, low vitamin D levels associated with long COVID syndrome in COVID-19 survivors, and clinical experience with the α2A-adrenoceptor agonist, guanfacine, and N-acetylcysteine for the treatment of cognitive deficits in “Long-COVID19”.

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 1001: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses an update on vaccine-derived poliovirus outbreaks, how the dream of wiping out polio might need a rethink, risk of death in patients hospitalized for COVID-19 vs seasonal Influenza in fall-winter, French Mpox cluster includes fully vaccinated patients, two individuals with potential Mpox virus reinfection, epidemiologic and clinical features of Mpox-associated deaths, FDA authorizes changes to simplify use of bivalent mRNA COVID-19 vaccines, SARS-CoV-2 during Omicron variant predominance among infants born to people with SARS-CoV-2, severe maternal morbidity and mortality of pregnant patients with COVID-19 infection during the early pandemic period in the US, sickness presenteeism in healthcare workers during the COVID-19 pandemic, ventilation improvements among k–12 public school districts, risk factors and vectors for SARS-CoV-2 household transmission, SARS-CoV-2 neutralizing antibodies after bivalent versus monovalent, durability of bivalent boosters against Omicron subvariants, Nirmatrelvir and risk of hospital admission or death in adults with COVID-19, evolving real-world effectiveness of monoclonal antibodies for treatment of COVID-19, effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support–free days in patients hospitalized with COVID-19, efficacy and safety of Anakinra plus standard of care for patients with severe COVID-19, higher dose corticosteroids in patients admitted to hospital with COVID-19 who are hypoxic but not requiring ventilatory support, risk of autoimmune diseases in patients with COVID-19, definition of post–COVID-19 condition among published research studies, and sleep disturbance severity and correlates in post-acute sequelae of COVID-19. 

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Intro music is by Ronald Jenkees

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TWiV 1000: Live from New York, 1k epitopes of virology

The entire TWiV team gathers at a theatre in New York City to celebrate a milestone in science podcasting, to reminisce how they joined the show, and to play a game of TWiV Jeopardy.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, Kathy Spindler, Brianne Barker, Daniel Griffin, and Angela Mingarelli

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Intro music is by Ronald Jenkees

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TWiV 999: Vaccinated to the nines

TWiV notes Ashish Jha’s call for doctors to combat a vacuum of medical information while ignoring our contributions, China CDC’s surveillance of SARS-CoV-2 at the Huanan Seafood Market, and an experimental infectious attenuated COVID-19 vaccine that elicits superior mucosal and systemic immunity in hamsters.

Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker

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Weekly Picks 1:29:27

Dickson – Jazz Project: Conductor/composer: Gill Evans. Produced Sketches of Spain, Porgy And Bess. Quincey Jones. Numerous albums, all kinds of music. Duke Ellington. Prolific musician, pianist, and composer. Antonio Carlos Jobim. Signature album: Sound track from the film – Black Orpheus. Signature songs: Girl From Ipanema; The Waters of March.
Brianne – This is what it sounds like when plants cry
Kathy – I know who you are by Barbara Rae-Venter
Alan – Svalbard seed vault virtual tour
Vincent – We’re Asking the Impossible of Vaccines by Katherine Wu

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 998: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses the White House COVID adviser calling on doctors to combat a vacuum of medical information, adeno-associated virus type 2 in US children with acute severe hepatitis, genomic investigations of unexplained acute hepatitis in children, surveillance of SARS-CoV-2 at the Huanan seafood market, vaccine effectiveness against hospitalization among adolescent and pediatric SARS-CoV-2 cases between May 2021 and January 2022 in Canada, effectiveness of BNT162b2 after extending the primary series dosing interval in children and adolescents aged 5–17, prevalence and characteristics associated with post–COVID-19 condition among non-hospitalized adolescents and young adults, within-host genetic diversity of SARS-CoV-2 lineages in unvaccinated and vaccinated individuals, live-attenuated vaccine sCPD9 elicits superior mucosal and systemic immunity to SARS-CoV-2 variants in hamsters, Fc-γR-dependent antibody effector functions are required for vaccine-mediated protection against antigen-shifted variants of SARS-CoV-2, COVID-19 convalescent plasma utilization in the United States, FDA authorizes Gohibic (vilobelimab) injection for the treatment of COVID-19, anti-C5a antibody IFX-1 (vilobelimab) treatment versus best supportive care for patients with severe COVID-19 (PANAMO), anti-C5a antibody (vilobelimab) therapy for critically ill, invasively mechanically ventilated patients with COVID-19, triple combination therapy with two antivirals and monoclonal antibodies for persistent or relapsed SARS-CoV-2 infection in immunocompromised patients, and the breadth of the neutralizing antibody response to original SARS-CoV-2 infection is linked to the presence of long COVID symptoms.

Click arrow to play Download TWiV 998 (26 MB .mp3, 43 min)

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 997: Inside Omicron with Mohsan Saeed

Mohsan joins TWiV to discuss the work of his laboratory showing that spike and nsp6 are determinants of Omicron attenuation, and why the work was widely misinterpreted by the press and the public.

Hosts: Vincent Racaniello, Alan Dove, and Rich Condit

Guest: Mohsan Saeed

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•Register for ASV 2023
•MicrobeTV Discord Server
• Spike and nsp6 determinants of Omicron attenuation (Nature) 24:00
•China releases genomic data from Wuhan market (Science) 1:38:39
•Timestamps by Jolene. Thanks!

Weekly Picks 1:39:24

Rich – For pianist Dan Tepfer, improvisation is the mother of Bach’s Inventions
Alan – HMS Victory 3D animated tour
Vincent – The Fight Over Penn Station and Madison Square Garden

Listener Picks

Douglas – How’s Your City Doing? Ask the Honeybees.

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 996: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses how antibiotics don’t reduce risk of death from viral respiratory infections, norovirus infections continue to rise in the US, ABO blood types and SARS-CoV-2 infection assessed using seroprevalence data in a large population-based sample, maternal third dose of BNT162b2 mRNA vaccine and risk of infant COVID-19 hospitalization, association of treatment with Nirmatrelvir and the risk of Post–COVID-19 condition, mechanically ventilated patients with COVID-19 had a higher chance of in-hospital death if treated with high-flow nasal cannula oxygen before intubation, high-flow nasal cannula and outcomes in COVID-19, severe infection and risk of Cardiovascular disease, and the risk factors associated with post−COVID-19 condition.

Click arrow to play Download TWiV 996 (26 MB .mp3, 43 min)

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 995: Viral origin stories

TWiV discusses genetic evidence of susceptible wildlife in SARS-CoV-2 positive samples at the Huanan Wholesale Seafood Market, polio cases in African linked to a new polio vaccine that was designed to not cause the disease, and structural conservation of hepatitis B virus capsid proteins over millions of years despite a shift from a naked to an enveloped capsid.

Hosts: Hosts: Vincent Racaniello, Dickson Despommier, Brianne Barker, and Angela Mingarelli

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•Register for ASV 2023
•MicrobeTV Discord Server
• More evidence for SARS-CoV-2 spillover (Zenodo) 6:54
•Polio cases linked to nOPV2 (Science; GPEI statement) 26:08
•nOPV2 on TWiV 756 30:17
•Engineering OPV to prevent reversion to neurovirulence (Cell Host Microbe) 30:17
•Stability of nOPV2 in children (npj Vaccines)
•2A changes compensate for 5′-UTR disruptions (Virology) 41:01
•HBV shifts from naked to enveloped (Nat Comm) 54:03
•Letters read on TWiV 995 1:24:14
•Timestamps by Jolene. Thanks!

Weekly Picks 1:42:18

Dickson – Jazz Project: Bass: Ray Brown, Ron Carter, Percy Heath
Angela – The nervous system may play a role in severe allergic reactions through immune cell (mast cells) cross-talk with neurons
Brianne – Science Museums Take Stock of 1.1 Billion Objects from Around the World
Vincent – Architect Breaks Down 5 of the Most Common Skyscraper Styles In New York

Listener Picks

Gary – Tony Fauci on PBS
Stefanie – What Do You Find Beautiful about Viruses? A Post-COVID Assessment Strategy

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

TWiV 994: Clinical update with Dr. Daniel Griffin

In his weekly clinical update, Dr. Griffin discusses the detection of circulating vaccine-derived poliovirus type 2 in Burundi and the Democratic Republic of the Congo, the novel oral polio vaccine type 2 story, prior COVID-19 infection associated with increased risk of newly diagnosed erectile dysfunction, adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection, correlates of protection against COVID-19 infection and intensity of symptomatic disease in vaccinated individuals exposed to SARS-CoV-2 in households in Israel, effectiveness of Nirmatrelvir–Ritonavir in preventing hospital admissions and deaths in people with COVID-19, projected COVID-19 mortality reduction from Paxlovid rollout, and SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity.

Click arrow to play Download TWiV 994 (26 MB .mp3, 43 min)

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Intro music is by Ronald Jenkees

Send your questions for Dr. Griffin to daniel@microbe.tv

TWiV 993: COVID-19 drives autoimmunity

TWiV reveals how treatment with remdesivir for COVID-19 resolved a chronic poliovirus infection in an immunocompromised patient, and the finding that infection with SARS-CoV-2 leads to an increase in new and preexisting autoantibodies.

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Become a patron of TWiV!

•Register for ASV 2023 2:20
•MicrobeTV Discord Server
•Janet Sinsheimer on TWiV 653 5:05
•Clearance of chronic poliovirus infection by remdesivir (Front Immunol) 7:47
•Autoimmunity induced by SARS-CoV-2 infection (Nat Comm) 33:08
•Letters read on TWiV 993 1:07:23
•Timestamps by Jolene. Thanks!

Weekly Picks 1:35:41

Brianne – Xkcd: Lymphocytes
Kathy – A brief history of Parafilm with video
Alan – Mapping and exploring the USS Monitor wreck
Vincent – Skype a Scientist

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv

The Hosts of TWiV

Vincent Racaniello, Ph.D.


Rich Condit, Ph.D.


Dickson D.
Despommier, Ph.D.


Alan Dove, Ph.D.


Daniel Griffin, M.D.,
Ph.D., CTropMed CTH


Angela Mingarelli, DVM


Jolene Ramsey, Ph.D.


CLICK FOR MORE INFO

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